[Research Progress on the Role of Berberine in Hematologic Malignancies and Its Related Mechanisms --Review].

Berberine, a traditional Chinese medicine, is an isoquinoline alkaloid extracted from the rhizome of Coptis chinensis. It has anti-inflammatory and antidiarrheal effects and is commonly used in the treatment of infections and gastrointestinal diseases. In recent years, studies have found that berberine can play a wide range of anti-cancer effects in the treatment of leukemia, lymphoma, multiple myeloma, etc. In hematologic malignancies, berberine can induce autophagy, promote apoptosis, regulate cell cycle, inhibit inflammatory response, cause oxidative damage to cancer cells and interact with miRNA to inhibit the proliferation, migration and colony formation of cancer cells. This paper will review the role and related mechanisms of berberine in hematological malignancies.

[Study on the relationship between iodine status and growth in infants at the key period of brain development].

OBJECTIVE: To investigate the relationship between iodine nutrition and growth/development in infants at the key period of brain development. METHODS: All women from pregnancy to the end of lactation and the weaning infants within 3 years in the Linxia Hui Autonomous Prefecture (Linxia Prefecture) were added iodized oil in 2006 - 2010. In 2006, 2010 one town was randomly selected from each of the five directions (east, south, west, north, central) of each county in Linxia Prefecture. One village was chosen from every town and 20 infants, 20 pregnant women and 20 lactating women were randomly selected in each town. Urinary iodine (UI) of the infants, pregnant and lactating women were determined. DQ value, height and weight of part of infants were measured. According to the above sampling plan, UI of pregnant women, lactating women and infants had been monitored every year after intervention. 0-3 infants were choosing to be control before intervention. RESULTS: UI of 1056 and 2989 0-3 infants were investigated before and after the iodine oil intervention. After the 'iodine oil' intervention, the median UI of infants increased from 107.3 µg/L to 139.6 - 190.7 µg/L, the percentage of UI level that lower than 50 µg/L, decreased from 23.9% to 6.7% - 12.9%. DQ value increased from 92.8 to 104.3, the percentage of normal height and above increased from 65.0% to 82.1% and the percentage of the normal weight and above, increased from 59.3% to 81.4%. The outcomes of DQ value, height and weight showed statistically significant differences, compared to the pre-intervention outcomes (P < 0.05). The median UI of pregnant and lactating women increased from 89.3 µg/L to 118.2 - 187.8 µg/L and from 84.9 µg/L to 135.2 - 187.5 µg/L respectively. CONCLUSION: Infant's growth and development were retarded when iodine deficiency existed at the key period of brain development. Intake of oral iodine oil at key period of brain development could provide adequate nutrition thus improve growth and development on infants.

[Improvement of universal salt iodization program on the intelligence quotient among children in Linxia Hui Autonomous Prefecture of Gansu].

OBJECTIVE: To assess the improvement of intelligence quotient through an Universal Salt Iodization Supply Program, among children. METHODS: 3518 and 1611 children were selected from primary schools in Linxia Hui Autonomous Prefecture of Gansu in 2006 and 2010 respectively. Intelligence quotient (IQ) were measured by the revised Chinese Combined Raven Test-C2 (CRT-C2). RESULTS: In 2006, the average IQ of children aged 8-10 was 85.1, including 16.7% of them with IQ ≤ 69. The average IQ was between 80-90 in different counties and cities, with significant differences (P < 0.05). The average IQs were 92.0, 90.6 and 81.8 among 8, 9 and 10 years old children respectively with 10 year old's low than those 8 and 9 year olds (P < 0.05). The average IQs of boys and girls were 84.5 and 85.6, but with no significant difference (P > 0.05). The average IQ of children aged 8-10 in 2010 was 97.2 and 12 points higher than in 2006 (P < 0.05), but 8 IQ points (P < 0.05) less than the average level 105 from the overall of Gansu province. 4.7% of the children having an IQ ≤ 69. IQ of children from Linxia city and Yongjing county, were up to the theoretical level of 100, with an average IQ at around 95 in other counties. The average IQs between counties or cities showed significant differences. The IQ of 8, 9 year olds and 10 year olds did not present significant difference (P > 0.05), but in boys (98.8) and in girls (95.9) the difference was significant (P < 0.05). CONCLUSION: The average IQ was close to the theoretical level (100) with the gradual implementation of universal salt iodization program, showing that the iodized salt did play a key role on children's intelligence. However, the average IQ was still lower than the average level of the whole Gansu province in 2010.