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1.
Physiol Behav ; 286: 114667, 2024 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-39151651

RESUMO

The aim of this study was to investigate the effect of 6-weeks resistance training (RT) on appetite, energy intake and body composition in young women with and without obesity, and to examine the relationship between these variables. Thirty-five young women were divided according to the amount of body fat [with obesity (n = 16) and without obesity (n = 19)]. Appetite was assessed through self-reported hunger, fullness, desire to eat, satiety quotient, food frequency diary and motivations to eat palatable food (power of food scale) in both fasted and fed states (after a standardized breakfast). Energy intake and body composition were evaluated at pre- and post-6 weeks of RT. Results showed that self-reported hunger increased significantly in both fasted and fed states (p = 0.007 and p = 0.029, respectively), while self-reported fullness decreased at the fasted state (p = 0.030) in both groups. There were no significant effects for desire to eat fatty, sweet, savory and salty foods, motivation to eat palatable foods, or for total energy intake. Food frequency analysis indicated a decrease in consumption of soup and past (p = 0.045), vegetables and eggs (p = 0.034), and leafy vegetables (p = 0.022) in both groups. Fat-free mass increased significantly in both groups (p = 0.011 and p = 0.003), while fat mass did not show significant changes. There were no correlations between changes in appetite/energy intake and changes in body composition. In conclusion, following the 6-week RT program, both women with and without obesity exhibited increased self-reported hunger alongside decreased fullness, suggesting an increase in orexigenic drive. However, neither group showed an increase in energy intake and fat mass, while both groups experienced an increase in fat-free mass. Registered under Brazilian Registry of Clinical Trials n°. RBR-1024f4qs.


Assuntos
Apetite , Composição Corporal , Ingestão de Energia , Obesidade , Treinamento Resistido , Humanos , Feminino , Ingestão de Energia/fisiologia , Obesidade/fisiopatologia , Obesidade/psicologia , Adulto Jovem , Treinamento Resistido/métodos , Apetite/fisiologia , Adulto , Composição Corporal/fisiologia , Fome/fisiologia , Comportamento Alimentar/fisiologia , Autorrelato , Adolescente , Jejum/fisiologia
2.
Eur J Clin Nutr ; 78(7): 647-650, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38485808

RESUMO

To investigate the effects of 8-weeks of full versus split body resistance training (RT) on appetite and energy intake in non-obese untrained men. The participants were pair-matched based on their initial fat mass and then randomly allocated into one of two treatment groups: Full body (FB, n = 20), in which all muscle groups were trained in every session, or Split body (SB, n = 15), in which upper and lower muscle groups were trained alternated per session; both groups trained in non-consecutive days, three times per week with total number of sets performed equated between groups. Energy intake, body composition, and strength performance were evaluated at pre-training, and after 8-weeks of RT, as well as self-reported hunger, fullness, and desire to eat, that were assessed at fasted and feed states pre- and post-intervention. FB and SB resistance training increased fat-free mass (FFM) (p < 0.001); and FB induced greater maximal strength improvement (p = 0.027). At fasted state self-reported hunger increased, and fullness decreased, while in feed state desire to eat something fatty increased in both groups. Carbohydrate intake (p = 0.011) decreased in both groups. In conclusion, FB and SB training increased orexigenic drive (increasing hunger and decreasing fullness), however, total energy intake and fat mass did not change after 8-weeks of RT in non-obese untrained men.Registered under Brazilian Registry of Clinical Trials no. RBR-3wkcvyw.


Assuntos
Apetite , Composição Corporal , Ingestão de Energia , Treinamento Resistido , Humanos , Masculino , Treinamento Resistido/métodos , Ingestão de Energia/fisiologia , Apetite/fisiologia , Adulto , Adulto Jovem , Fome/fisiologia , Força Muscular/fisiologia
3.
Appetite ; 193: 107155, 2024 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-38081545

RESUMO

PURPOSE: The effects of exercise on appetite have recently been systematically evaluated with a focus on endurance training (ET). However, resistance training (RT) may induce different adaptations than ET. This scoping review aimed to examine the acute and chronic effects of isolated RT and comparisons with other exercise modalities on appetite-related variables and energy intake. RESULTS: 17 acute studies were identified, six examining isolated RT, while 11 focused on RT intensity, amount of exercise, targeted muscle groups, or comparison with ET and combined training (RT plus ET; CT). Nine chronic studies were identified. Three investigated isolated RT vs control and six manipulated the amount of RT exercise, types of RT, or comparison with ET and CT. CONCLUSIONS: Acute RT compared to control conditions appears to induce responses favoring appetite inhibition. While the amount of RT exercise may acutely play a role in the suppression of appetite, while ET seems to have more potential to suppress appetite. Chronic RT does not seem to stimulate compensatory mechanisms; however, there is not clear evidence regarding the role of RT intensity or other exercise modalities. Chronic ET and CT may be more prone to favor appetite inhibition than RT. More comprehensive evaluations including the exploration of multiple appetite-related factors are needed for future studies.


Assuntos
Apetite , Treinamento Resistido , Humanos , Apetite/fisiologia , Exercício Físico/fisiologia , Ingestão de Energia/fisiologia , Metabolismo Energético/fisiologia
4.
PLoS One ; 18(11): e0293413, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37910576

RESUMO

The taxation of sugar-sweetened beverages is a policy that has been adopted in many countries worldwide, including Latin American, to reduce sugar consumption. However, little is known about how taxation on these products may affect their demand. The present study aims to estimate the price elasticity of demand for sugar-sweetened beverages in Brazil. This study advances the literature by proposing a breakdown between ready-to-drink sugar-sweetened beverages and sugar-sweetened beverages that require some preparation before being consumed. With this disaggregation, it is possible to obtain more accurate elasticities for the group of products that will be effectively taxed. We estimated a Quadratic Almost Ideal Demand System (QUAIDS) model using the Household Budget Survey 2017-2018 microdata. The results show that ready-to-drink beverages is more consumed but less sensitive to changes in price than prepared beverages. The price elasticity of demand for ready-to-drink and prepared sugar-sweetened beverages was -1.19 and -3.38. Additionally, we observe heterogeneity in these price elasticities across household incomes, with a more elastic demand among lower-income households for ready to drink beverages. The findings suggest that taxing ready-to-drink sweetened beverages could potentially reduce sugar consumption directly through a decrease in the consumption of sugary drinks and this effect could be reinforced by reducing the consumption of other sugar-rich products. Therefore, the taxation police should effective contribute to minimize health risks associated to the sugar consumption.


Assuntos
Bebidas Adoçadas com Açúcar , Brasil , Bebidas , Açúcares , Impostos , Açúcares da Dieta , Elasticidade , Comércio
5.
Rev Esc Enferm USP ; 57(spe): e20220382, 2023.
Artigo em Inglês, Português | MEDLINE | ID: mdl-37992302

RESUMO

OBJECTIVE: To analyze the conceptions about COVID-19 among Brazilians who carry out commuting to work in clandestine mines located on the borders between Brazil, French Guiana and Suriname. METHOD: This is qualitative research, from an analytical perspective, based on Social Representation Theory. Semi-structured, audio-recorded interviews were carried out with 10 Brazilians who experience work routine in clandestine mining on the border between Brazil, French Guiana and Suriname. RESULTS: Two analytical categories emerged: "The disease of otherness"; and "Health access dimension". CONCLUSION: Disease severity was attributed to another or a human body organ, and not to individuals as a whole. Access to health services was established on issues of inequity, violence and illegal practices. The nature of a transient population, which carries out commuting and informal and clandestine work, demonstrates vulnerability to COVID-19 and a lower propensity to receive care.


Assuntos
COVID-19 , Migrantes , Humanos , Pandemias , Guiana Francesa/epidemiologia , Brasil/epidemiologia
7.
Rev. Esc. Enferm. USP ; 57(spe): e20220382, 2023. tab
Artigo em Inglês, Português | LILACS, BDENF - enfermagem (Brasil) | ID: biblio-1521575

RESUMO

ABSTRACT Objective: To analyze the conceptions about COVID-19 among Brazilians who carry out commuting to work in clandestine mines located on the borders between Brazil, French Guiana and Suriname. Method: This is qualitative research, from an analytical perspective, based on Social Representation Theory. Semi-structured, audio-recorded interviews were carried out with 10 Brazilians who experience work routine in clandestine mining on the border between Brazil, French Guiana and Suriname. Results: Two analytical categories emerged: "The disease of otherness"; and "Health access dimension". Conclusion: Disease severity was attributed to another or a human body organ, and not to individuals as a whole. Access to health services was established on issues of inequity, violence and illegal practices. The nature of a transient population, which carries out commuting and informal and clandestine work, demonstrates vulnerability to COVID-19 and a lower propensity to receive care.


RESUMEN Objetivo: Analizar las concepciones sobre el COVID-19 entre los brasileños que realizan desplazamientos para trabajar en minas clandestinas ubicadas en las fronteras entre Brasil, Guayana Francesa y Surinam. Método: Investigación cualitativa, desde una perspectiva analítica, basada en la Teoría de las Representaciones Sociales. Se realizaron entrevistas semiestructuradas y grabadas en audio a 10 brasileños que viven la rutina de trabajo en minas clandestinas en la frontera entre Brasil, Guayana Francesa y Surinam. Resultados: Se designaron dos categorías analíticas: "La enfermedad de la alteridad"; y "Dimensiones del acceso a la salud". Conclusión: La gravedad de la enfermedad se atribuyó a otro o a un órgano del cuerpo humano, y no al individuo en su conjunto. El acceso a los servicios de salud se estableció sobre temas de inequidad, violencia y prácticas ilegales. La naturaleza de la población transitoria, que realiza desplazamientos y trabajos informales y clandestinos, demuestra vulnerabilidad al COVID-19 y una menor propensión a recibir atención.


RESUMO Objetivo: Analisar as concepções acerca da covid-19 entre brasileiros que realizam migração pendular para trabalhar em garimpos clandestinos situados nas fronteiras entre Brasil, Guiana Francesa e Suriname. Método: Pesquisa qualitativa, em uma perspectiva analítica, alicerçada na Teoria das Representações Sociais. Foram realizadas entrevistas semiestruturadas, áudiogravadas com 10 brasileiros que vivenciam a rotina de trabalho em garimpos clandestinos na fronteira entre Brasil, Guiana Francesa e Suriname. Resultados: Foram designadas duas categorias analíticas: "A doença da alteridade"; e "Dimensão do acesso à saúde". Conclusão: A gravidade da doença foi atribuída ao outro ou a um órgão do corpo humano, e não ao indivíduo como um todo. O acesso aos serviços de saúde instituiu-se em questões de iniquidade, violência e práticas ilegais. O caráter de população transitória, que realiza migração pendular e de trabalho informal e clandestino, demonstra vulnerabilidade à covid-19 e menor propensão a receber cuidados.


Assuntos
Humanos , Infecções por Coronavirus , Saúde na Fronteira , Pesquisa Qualitativa , Áreas de Fronteira , COVID-19 , Mineração
8.
Rev Soc Bras Med Trop ; 55: e05922021, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35613224

RESUMO

Over the years, vaccinations have provided significant advances in public health, because they substantially reduce the morbimortality of vaccine-preventable diseases. Nevertheless, many people are still hesitant to be vaccinated. Brazil is a region of many anti-vaccine movements, and several outbreaks of vaccine-preventable diseases, such as yellow fever and measles, have occurred in the country during the last few years. To avoid new outbreaks, immunization coverage must be high; however, this is a great challenge to achieve due to the countless anti-vaccine movements. The World Health Organization has suggested new actions for the next decade via the Immunization Agenda 2030 to control, reduce, or eradicate vaccine-preventable diseases. Nonetheless, the vaccination coverage has decreased recently. To resolve the anti-vaccine issue, it is necessary to propose a long-term approach that involves innovative education programs on immunization and critical thinking, using different communication channels, including social media. Cooperation among biology and health scientists, ethicists, human scientists, policymakers, journalists, and civil society is essential for an in-depth understanding of the social action of vaccine refusal and planning effective education measures to increase the vaccine coverage.


Assuntos
Sarampo , Doenças Preveníveis por Vacina , Vacinas , Movimento contra Vacinação , Brasil , Humanos , Programas de Imunização , Sarampo/epidemiologia , Sarampo/prevenção & controle , Vacinação
9.
Rev. Soc. Bras. Med. Trop ; 55: e0592, 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1376338

RESUMO

ABSTRACT Over the years, vaccinations have provided significant advances in public health, because they substantially reduce the morbimortality of vaccine-preventable diseases. Nevertheless, many people are still hesitant to be vaccinated. Brazil is a region of many anti-vaccine movements, and several outbreaks of vaccine-preventable diseases, such as yellow fever and measles, have occurred in the country during the last few years. To avoid new outbreaks, immunization coverage must be high; however, this is a great challenge to achieve due to the countless anti-vaccine movements. The World Health Organization has suggested new actions for the next decade via the Immunization Agenda 2030 to control, reduce, or eradicate vaccine-preventable diseases. Nonetheless, the vaccination coverage has decreased recently. To resolve the anti-vaccine issue, it is necessary to propose a long-term approach that involves innovative education programs on immunization and critical thinking, using different communication channels, including social media. Cooperation among biology and health scientists, ethicists, human scientists, policymakers, journalists, and civil society is essential for an in-depth understanding of the social action of vaccine refusal and planning effective education measures to increase the vaccine coverage.

11.
J Anim Sci ; 99(10)2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34599328

RESUMO

Ingestion of mycotoxins can result in many problems, including decreased growth rates and immune suppression. The present study aimed to evaluate the impact of the supplementation of a mycotoxin deactivator composed by adsorbent clay minerals; inactivated fermentation extracts of Saccharomyces cerevisiae; and blend of antioxidants, organic acids, and botanicals in diets containing added mycotoxins for nursery pigs on their performance and antioxidant status. Ninety pigs weaned with 24 d of age (7.12 ± 0.68 kg of BW) were used. Pigs were housed in pens of three animals each according to body weight, litter origin, and sex. The dietary treatments consisted of feeding the pigs with a standard control diet as negative control (NC; mycotoxin levels at accepted regulatory Brazilian Ministry of Agriculture standards; deoxynivalenol (DON): <100 µg/kg; zearalenone (ZEA): <20 µg/kg; fumonisins (FB): <1 mg/kg); the standard diet added with mycotoxins to reach a low contamination level is considered as positive low (PCL-; DON: 900 µg/kg; ZEA: 100 µg/kg; FB: 5,000 µg/kg) without deactivator; a positive low added the deactivator at an inclusion rate of 1 kg/ton (PCL+); the standard diet added with mycotoxins to reach a high contamination level is considered as positive high (PCH-; DON: 4,500 µg/kg; ZEA: 500 µg/kg; FB: 18,000 µg/kg) without the deactivator; and a positive high added the deactivator at an inclusion rate of 5 kg/ton (PCH+). Pigs were individually weighed at the beginning and at the end of each phase and feed intake recorded based on daily pen intake during the experiment. On days 7, 19, 34, and 43 post-weaning, blood samples were drawn for antioxidant analyses. Antioxidant enzymes (glutathione peroxidase [GPx] and total superoxide dismutase [TSOD]), vitamins [Vit A, E, and C], and malondialdehyde [MDA]) were evaluated in erythrocyte and plasma samples. Pigs challenged with mycotoxins presented lower performance traits, decrease in the efficiency of central antioxidant systems (↓GPx, ↓TSOD, ↓Vit A, ↓Vit E, and ↓Vit C), and a higher oxidative damage to lipids (↑MDA) when compared with the control and deactivator-associated treatments. Our findings showed that the use of a mycotoxin deactivator can mitigate the negative impacts on performance and oxidative stress when animals are subjected to diets contaminated by different levels of mycotoxins.


Assuntos
Micotoxinas , Ração Animal/análise , Animais , Antioxidantes , Dieta/veterinária , Estresse Oxidativo , Suínos
12.
PLoS One ; 16(2): e0246475, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33596233

RESUMO

The efficiency of public policies includes the measurement of the health resources used and their associated costs. There is a lack of studies evaluating the economic impact of oral cancer (OC). This study aims to estimate the healthcare costs of OC in Brazil from 2008 to 2016. This is a partial economic evaluation using the gross costing top-down method, considering the direct healthcare costs related to outpatients, inpatients, intensive care units, and the number of procedures, from the perspective of the public health sector. The data were extracted from the Outpatient and Inpatient Information System of the National Health System, by diagnosis according to the 10th Revision of the International Classification of Diseases, according to sites of interest: C00 to C06, C09 and C10. The values were adjusted for annual accumulated inflation and expressed in 2018 I$ (1 I$ = R$2,044). Expenditure on OC healthcare in Brazil was I$495.6 million, which was composed of 50.8% (I$251.6 million) outpatient and 49.2% (I$244.0 million) inpatient healthcare. About 177,317 admissions and 6,224,236 outpatient procedures were registered. Chemotherapy and radiotherapy comprised the largest number of procedures (88.8%) and costs (94.9%). Most of the costs were spent on people over 50 years old (72.9%) and on males (75.6%). Direct healthcare costs in Brazil for OC are substantial. Outpatient procedures were responsible for the highest total cost; however, inpatient procedures had a higher cost per procedure. Men over 50 years old consumed most of the cost and procedures for OC. The oropharynx and tongue were the sites with the highest expenditure. Further studies are needed to investigate the cost per individual, as well as direct non-medical and indirect costs of OC.


Assuntos
Atenção à Saúde/economia , Custos de Cuidados de Saúde/estatística & dados numéricos , Neoplasias Bucais/economia , Brasil , Efeitos Psicossociais da Doença , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Masculino , Neoplasias Orofaríngeas/economia
15.
J. bras. psiquiatr ; 69(3): 156-164, jul.-set. 2020. tab
Artigo em Português | LILACS-Express | LILACS | ID: biblio-1134958

RESUMO

RESUMO Objetivo Avaliar a prevalência de insatisfação com a imagem corporal e os fatores associados entre universitários da área da saúde. Métodos Trata-se de um estudo descritivo, de caráter transversal e abordagem quantitativa, com 364 acadêmicos matriculados em cinco cursos da área da saúde. Para a obtenção dos dados, foram utilizados seis instrumentos autoaplicáveis: questionário socioeconômico, demográfico e de hábitos de vida adaptado do Vigitel, o Body Shape Questionnaire (BSQ), o Eating Attitudes Test (EAT-26), o Questionário Internacional de Atividade Física (IPAQ), o Inventário de Ansiedade de Beck (BAI) e o Inventário de Depressão de Beck (BDI). Foram coletadas, ainda, as medidas antropométricas. A associação entre as variáveis estudadas e a insatisfação com a imagem corporal foi verificada por análise bivariada seguida de regressão logística, com variância robusta. Resultados Houve prevalência de insatisfação com a imagem corporal de 9,1% entre os universitários. As variáveis que, após análise múltipla, se mostraram associadas a maior prevalência de insatisfação com a imagem corporal foram: cor da pele não branca, realização de tratamento para perder peso, presença de atitudes para transtorno alimentar, estado de saúde regular/ruim, ansiedade moderada/grave e circunferência abdominal. Conclusão A prevalência com a insatisfação com a imagem corporal nos universitários foi baixa, entretanto fatores sociodemográficos, estilo de vida, estado de saúde e condições clínicas e antropométricas mostraram-se associados com a prevalência da insatisfação com a imagem corporal.


ABSTRACT Objective To assess the prevalence of dissatisfaction with body image and associated factors among university students in the health field. Methods This is a descriptive, cross-sectional study with a quantitative approach, with 364 students enrolled in five health courses. To obtain the data, six self-administered instruments were used: socioeconomic, demographic and lifestyle habits adapted from Vigitel, the Body Shape Questionnaire (BSQ), the Eating Attitudes Test (EAT-26), the International Physical Activity Questionnaire (IPAQ), the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory (BDI). Anthropometric measurements were also collected. The association between the studied variables and dissatisfaction with body image was verified by bivariate analysis followed by logistic regression, with robust variance. Results There was a prevalence of body image dissatisfaction of 9.1% among university students. The variables that, after multiple analysis, were associated with a higher prevalence of dissatisfaction with body image were: non-white skin color, undergoing treatment to lose weight, presence of attitudes towards eating disorder, regular/poor health status, moderate/severe anxiety and waist circumference. Conclusion It is concluded that the prevalence of dissatisfaction with body image in university students was low, however, sociodemographic factors, lifestyle, health status and clinical and anthropometric conditions were shown to be associated with the prevalence of dissatisfaction with body image.

16.
Fisioter. Bras ; 19(6): 739-745, 20 de dezembro de 2018. graf
Artigo em Português | LILACS-Express | LILACS | ID: biblio-1146330

RESUMO

Introdução: O Teste de Caminhada de 6 minutos (TC6) tem sido utilizado especialmente para mensurar a capacidade funcional e avaliar a eficiência de diversos tratamentos cardiovasculares. Objetivo: O objetivo do presente estudo foi aplicar e comparar as equações preditas do TC6, em indivíduos hipertensos participantes de reabilitação cardiovascular (RCV). Material e métodos: A amostra foi composta por 39 pacientes de ambos os sexos (masculino: 11 e feminino: 28) com média de idade 57,5 ± 11 anos portadores de hipertensão arterial. Resultados: Após o programa de RCV foi verificado um aumento significativo (p < 0,001) da distância caminhada no TC6 quando comparada aos valores antes da RCV (514,7 ± 100,6 x 382,4 ± 116,3 m). Entretanto, não houve diferença estatística quando comparado os valores preditos das duas equações. Conclusão: A distância percorrida no TC6 foi maior após a RCV quando comparada aos valores iniciais, demostrando que a RCV produz benefícios na capacidade funcional dessa população. Além disso, os resultados sugerem que as duas equações avaliadas, tem aplicabilidade semelhante para a população de indivíduos hipertensos brasileiros.


Introduction: The 6-minute Walk Test (6MWT) has been used especially to measure functional capacity, to evaluate the efficiency of various cardiovascular treatments. Objective: The objective of the present study was to apply and compare the predicted EQ6 equations in hypertensive individuals participating in cardiovascular rehabilitation (CR). Methods: The sample consisted of 39 patients of both sexes (male: 11 and female: 28) with mean age 57.5 ± 11 years old with arterial hypertension. Results: After the CR program, was verified a significant increase (p < 0.001) in the 6MWT when compared to values before of CR (514.7 ± 100.6 x 382.4 ± 116.3 m). However, there was no statistical difference when compared to the predicted values of the two equations. Conclusion: The distance walked on the 6MWT was higher after the RCV when compared to the initial values, showing that the RCV produces benefits in the functional capacity of this population. In addition, the results suggest that the two equations evaluated have similar applicability for the population of Brazilian hypertensive individuals.

17.
World J Microbiol Biotechnol ; 33(12): 211, 2017 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-29134289

RESUMO

Cultivable microbiota presents in a coffee semi-dry processing wastewater treatment plant (WTP) was identified. Thirty-two operational taxonomic units (OTUs) were detected, these being 16 bacteria, 11 yeasts and 4 filamentous fungi. Bacteria dominated the microbial population (11.61 log CFU mL- 1), and presented the highest total diversity index when observed in the WTP aerobic stage (Shannon = 1.94 and Simpson = 0.81). The most frequent bacterial species were Enterobacter asburiae, Sphingobacterium griseoflavum, Chryseobacterium bovis, Serratia marcescens, Corynebacterium flavescens, Acetobacter orientalis and Acetobacter indonesiensis; these showed the largest total bacteria populations in the WTP, with approximately 10 log CFU mL- 1. Yeasts were present at 7 log CFU mL- 1 of viable cells, with Hanseniaspora uvarum, Wickerhamomyces anomalus, Torulaspora delbrueckii, Saturnispora gosingensis, and Kazachstania gamospora being the prevalent species. Filamentous fungi were found at 6 log CFU mL- 1, with Fusarium oxysporum the most populous species. The identified species have the potential to act as a biological treatment in the WTP, and the application of them for this purpose must be better studied.


Assuntos
Bactérias/classificação , Café , Manipulação de Alimentos , Fungos/classificação , Águas Residuárias/microbiologia , Leveduras/classificação , Bactérias/isolamento & purificação , Biodiversidade , Fungos/isolamento & purificação , Microbiota , Filogenia , Leveduras/isolamento & purificação
18.
Biochem Cell Biol ; 94(5): 451-458, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27563837

RESUMO

Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue that was recently approved to treat obesity in some countries. Considering that liraglutide effects on brain energy metabolism are little known, we evaluated the effects of liraglutide on the energy metabolism. Animals received a single or daily injection of saline or liraglutide during 7 days (25, 50, 100, or 300 µg/kg i.p.). Twenty-four hours after the single or last injection, the rats were euthanized and the hypothalamus, prefrontal cortex, cerebellum, hippocampus, striatum, and posterior cortex were isolated. Our results demonstrated that a single dose of liraglutide in young rats increased the activity of complexes and inhibited creatine kinase activity. Repeated administrations of liraglutide in young rats reduced the activity of complexes and activated creatine kinase activity. In adult rats, a single dose of liraglutide reduced the activity of complex I and creatine kinase and increased the activity of complexes II and IV. Repeated administrations of liraglutide in adult rats increased the activity of complexes I and IV and reduced the activity of complex II and creatine kinase. We concluded that liraglutide may interfere in energy metabolism, because analysis of different times of administrations, concentrations, and level of brain development leads to divergent results.


Assuntos
Encéfalo/metabolismo , Metabolismo Energético/efeitos dos fármacos , Hipoglicemiantes/farmacologia , Liraglutida/farmacologia , Envelhecimento , Animais , Encéfalo/efeitos dos fármacos , Creatina Quinase/metabolismo , Relação Dose-Resposta a Droga , Complexo I de Transporte de Elétrons/metabolismo , Complexo II de Transporte de Elétrons/metabolismo , Complexo III da Cadeia de Transporte de Elétrons/metabolismo , Complexo IV da Cadeia de Transporte de Elétrons/metabolismo , Humanos , Hipoglicemiantes/administração & dosagem , Liraglutida/administração & dosagem , Masculino , Ratos , Ratos Wistar
19.
Metabolism ; 64(9): 967-81, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26072135

RESUMO

Currently, obesity and its associated complications are considered major public health problems worldwide. Because the causes are multifactorial and complex, different treatment methods are used, which include diet and exercise, as well as the use of drugs, although they can have adverse side effects. A new target for the treatment of obesity may be the incretin system, which consists of hormones that seem to contribute to weight loss. In this sense, some studies have shown a relationship between weight loss and drugs related to incretin system, including glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors. The objective of this review is to summarize the association between the incretin system and obesity treatment.


Assuntos
Fármacos Antiobesidade/uso terapêutico , Incretinas/uso terapêutico , Obesidade/tratamento farmacológico , Animais , Inibidores da Dipeptidil Peptidase IV/uso terapêutico , Peptídeo 1 Semelhante ao Glucagon/agonistas , Humanos , Incretinas/fisiologia , Obesidade/fisiopatologia , Receptores dos Hormônios Gastrointestinais/agonistas , Receptores dos Hormônios Gastrointestinais/antagonistas & inibidores
20.
Dental press j. orthod. (Impr.) ; 19(6): 105-112, Nov-Dec/2014. tab, graf
Artigo em Inglês | LILACS | ID: lil-732435

RESUMO

INTRODUCTION: At orthodontic treatment completion, knowledge about the effects of adhesive remnant removal on enamel is paramount. OBJECTIVE: This study aimed at assessing the effect of different adhesive remnant removal methods on enamel topography (ESI) and surface roughness (Ra) after bracket debonding and polishing. METHODS: A total of 50 human premolars were selected and divided into five groups according to the method used for adhesive remnant removal: high speed tungsten carbide bur (TCB), Sof-Lex discs (SL), adhesive removing plier (PL), ultrasound (US) and Fiberglass burs (FB). Metal brackets were bonded with Transbond XT, stored at 37oC for 24 hours before debonding with adhesive removing plier. Subsequently, removal methods were carried out followed by polishing with pumice paste. Qualitative and quantitative analyses were conducted with pre-bonding, post-debonding and post-polishing analyses. Results were submitted to statistical analysis with F test (ANOVA) and Tukey's (Ra) as well as with Kruskal-Wallis and Bonferroni tests (ESI) (P < 0.05). RESULTS: US Ra and ESI were significantly greater than TCB, SL, PL and FB. Polishing minimized Ra and ESI in the SL and FB groups. CONCLUSION: Adhesive remnant removal with SL and FB associated with polishing are recommended due to causing little damage to the enamel. .


INTRODUÇÃO: na finalização do tratamento ortodôntico, torna-se relevante o conhecimento da ação dos métodos de remoção do remanescente resinoso sobre o esmalte. OBJETIVO: o objetivo do estudo foi avaliar o efeito de métodos de remoção do remanescente de resina após a descolagem do braquete e do polimento na rugosidade (Ra) e topografia (ESI) do esmalte. MÉTODOS: foram selecionados 50 pré-molares humanos, divididos em cinco grupos, de acordo com o método empregado para a remoção da resina residual: broca carbide tungstênio em alta rotação (BCT), discos Sof-Lex (SL), alicate removedor de resina (AL), ultrassom (US) e pontas Fiberglass (PF). Braquetes metálicos foram colados com Transbond XT, armazenados a 37° por 24 horas antes da descolagem com alicate removedor de braquete, sendo aplicados posteriormente os meios de remoção e executado o polimento com pasta de pedra-pomes. Realizou-se análises qualiquantitativas, com avaliações antes da colagem dos braquetes, após a descolagem e após o polimento, sendo os valores obtidos submetidos à análise estatística com teste F (ANOVA), de Tukey (Ra) e testes de Kruskal-Wallis e Bonferroni (ESI) (p < 0,05). RESULTADOS: a Ra e o ESI do US foram significativamente maiores do que BCT, SL, AL e PF. O polimento reduziu a Ra e ESI dos grupos SL e PF. CONCLUSÃO: a remoção do adesivo resinoso com SL e PF associados ao polimento são os métodos mais indicados por ocasionarem as menores alterações do esmalte. .


Assuntos
Humanos , Descolagem Dentária/métodos , Esmalte Dentário/anatomia & histologia , Braquetes Ortodônticos , Cimentos de Resina/química , Dente Pré-Molar/anatomia & histologia , Equipamentos Odontológicos de Alta Rotação , Ligas Dentárias/química , Materiais Dentários/química , Profilaxia Dentária/instrumentação , Profilaxia Dentária/métodos , Desenho de Equipamento , Vidro/química , Teste de Materiais , Propriedades de Superfície , Silicatos/química , Temperatura , Fatores de Tempo , Compostos de Tungstênio/química , Ultrassom/instrumentação
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