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1.
Early Interv Psychiatry ; 12(3): 456-463, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-27172538

RESUMO

AIM: The aim of this study was to evaluate the differences between teachers' knowledge about early psychosis among three different Italian cities and a UK sample. METHODS: The sample consisted of 556 secondary school teachers from three different cities in Italy (Milan, Rome and Lamezia Terme) and London (UK). The research was based on the Knowledge and Experience of Social Emotional Difficulties Among Young People Questionnaire. The Italian version of the questionnaire was used in Italy. RESULTS: Overall, 67.6% of English teachers, 58.5% of Milan's teachers, 41.8% of Rome's teachers and 33.3% of Lamezia Terme's teachers were able to recognize psychotic symptoms from a case vignette. Logistic regression analysis showed that 'city' was the only independent variable significantly related to the correct/wrong answer about diagnosis. CONCLUSIONS: We found statistically significant differences between the three Italian samples and the UK sample regarding teachers' knowledge about first signs of psychosis. English teachers showed a better knowledge than Italian teachers in general. Teachers from Milan, where a specific early detection program was established in 2000, seemed to be more familiar with early signs of psychosis than teachers in the other two Italian towns.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Transtornos Psicóticos/diagnóstico , Professores Escolares/estatística & dados numéricos , Capacitação de Professores/estatística & dados numéricos , Diagnóstico Precoce , Humanos , Itália , Londres , Transtornos Psicóticos/psicologia , Inquéritos e Questionários
2.
Early Interv Psychiatry ; 6(1): 76-82, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21951941

RESUMO

AIMS: We sought to evaluate secondary school teachers' knowledge about psychosis and their level of interest in this topic given the key role they may be able to play in the early detection of psychosis. METHODS: A questionnaire survey of 268 secondary school teachers from eight secondary schools within the Azienda Sanitaria Locale Rome/E and Rome/A catchment areas (two of the five city health districts) in Rome. Teachers were asked to complete the Italian version Esperienza e Conoscenza delle Difficoltò Sociali ed Emotive dei Giovani of the Knowledge and Experience of Social Emotional Difficulties among Young people self-report questionnaire that investigates the diagnosis, age of onset, aetiology, prognosis and treatment of psychosis. They were also asked about their experience with pupils with possible psychosis. RESULTS: Most of teachers were able to recognize psychotic symptoms from a case vignette. Approximately 25% of the teachers had experienced a pupil with possible symptoms of psychosis. However, teachers displayed little awareness of psychiatric community services available for young people. CONCLUSIONS: Our study shows that teachers may play an important role in early detection and psychosis prevention strategies. The teachers also displayed a keen interest in gaining a deeper knowledge of early psychotic signs and in cooperating closely with a mental health specialist to obtain guidance and support when faced with serious mentally ill pupils.


Assuntos
Docentes/estatística & dados numéricos , Transtornos Psicóticos/psicologia , Adulto , Coleta de Dados , Diagnóstico Precoce , Feminino , Letramento em Saúde/estatística & dados numéricos , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Transtornos Psicóticos/diagnóstico , Cidade de Roma , Instituições Acadêmicas
3.
Metabolism ; 52(11): 1433-8, 2003 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14624402

RESUMO

The current study sought to investigate the role of low-density lipoprotein receptor (LDLr) mutations in assessing the risk profile of familial hypercholesterolemia (FH) patients, independently of major cardiovascular risk factors. FH due to LDLr mutations is associated with premature atherosclerosis. The variable clinical severity of the disease in heterozygotes has been related to cholesterol levels and the coexistence of other cardiovascular risk factors, but the independent role of different LDLr mutations is still unclear. cDNA of LDL gene was sequenced in 102 patients with clinical features of heterozygous FH. Carotid artery intima-media thickness (IMT) was measured by B-mode ultrasound imaging in all patients. Sixteen different mutations (5 never described) were found in 82 patients (49 families; mean age, 39 years; 53% women). One of the newly described mutations, the 2312-3 C-->A, was found in 24 patients (13 families). The mean of maximum thicknesses was significantly higher in the 2312-3 C-->A group than in patients with other LDLr mutations (P=.004 after adjustment for major cardiovascular risk factors). Similar results (P=.001) were obtained in the adjusted comparisons of probands only, and of the patients with similar baseline cholesterol (P=.002). This study indicates that the identification of an LDLr mutation can help to assess the risk profile of FH patients independently of the major cardiovascular risk factors.


Assuntos
Doenças Cardiovasculares/genética , Artérias Carótidas/patologia , Mutação/genética , Mutação/fisiologia , Receptores de LDL/genética , Adolescente , Adulto , Arteriosclerose/genética , Arteriosclerose/patologia , Doenças Cardiovasculares/diagnóstico por imagem , Doenças Cardiovasculares/patologia , Artérias Carótidas/diagnóstico por imagem , Criança , Colesterol/sangue , DNA Complementar/biossíntese , DNA Complementar/genética , Ecocardiografia , Meio Ambiente , Comportamento Alimentar , Feminino , Humanos , Hiperlipoproteinemia Tipo II/diagnóstico por imagem , Hiperlipoproteinemia Tipo II/genética , Estilo de Vida , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Tendões/patologia , Xantomatose/patologia
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