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1.
Science ; 372(6546): 1081-1085, 2021 06 04.
Artigo em Inglês | MEDLINE | ID: mdl-34083487

RESUMO

Gamma-ray bursts (GRBs), which are bright flashes of gamma rays from extragalactic sources followed by fading afterglow emission, are associated with stellar core collapse events. We report the detection of very-high-energy (VHE) gamma rays from the afterglow of GRB 190829A, between 4 and 56 hours after the trigger, using the High Energy Stereoscopic System (H.E.S.S.). The low luminosity and redshift of GRB 190829A reduce both internal and external absorption, allowing determination of its intrinsic energy spectrum. Between energies of 0.18 and 3.3 tera-electron volts, this spectrum is described by a power law with photon index of 2.07 ± 0.09, similar to the x-ray spectrum. The x-ray and VHE gamma-ray light curves also show similar decay profiles. These similar characteristics in the x-ray and gamma-ray bands challenge GRB afterglow emission scenarios.

2.
Nature ; 575(7783): 464-467, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31748724

RESUMO

Gamma-ray bursts (GRBs) are brief flashes of γ-rays and are considered to be the most energetic explosive phenomena in the Universe1. The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed2. GRBs typically emit most of their energy via γ-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments3. However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive4. Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and γ-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.

3.
Phys Rev Lett ; 120(20): 201101, 2018 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-29864326

RESUMO

Spectral lines are among the most powerful signatures for dark matter (DM) annihilation searches in very-high-energy γ rays. The central region of the Milky Way halo is one of the most promising targets given its large amount of DM and proximity to Earth. We report on a search for a monoenergetic spectral line from self-annihilations of DM particles in the energy range from 300 GeV to 70 TeV using a two-dimensional maximum likelihood method taking advantage of both the spectral and spatial features of the signal versus background. The analysis makes use of Galactic center observations accumulated over ten years (2004-2014) with the H.E.S.S. array of ground-based Cherenkov telescopes. No significant γ-ray excess above the background is found. We derive upper limits on the annihilation cross section ⟨σv⟩ for monoenergetic DM lines at the level of 4×10^{-28} cm^{3} s^{-1} at 1 TeV, assuming an Einasto DM profile for the Milky Way halo. For a DM mass of 1 TeV, they improve over the previous ones by a factor of 6. The present constraints are the strongest obtained so far for DM particles in the mass range 300 GeV-70 TeV. Ground-based γ-ray observations have reached sufficient sensitivity to explore relevant velocity-averaged cross sections for DM annihilation into two γ-ray photons at the level expected from the thermal relic density for TeV DM particles.

4.
J Fish Dis ; 40(8): 1001-1014, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28026022

RESUMO

Histopathological, immunofluorescence and ultrastructural studies were conducted on the intestines of four fish species infected with different taxa of enteric helminths. Brown trout (Salmo trutta trutta), eel (Anguilla anguilla) and tench (Tinca tinca) obtained from Lake Piediluco (central Italy) were examined. Brown trout and eel were infected with two species of acanthocephalans, and tench was parasitized with a tapeworm species. In addition to the above site, specimens of chub (Squalius cephalus) and brown trout infected with an acanthocephalan were examined from the River Brenta (north Italy). Moreover, eels were examined from a brackish water, Comacchio lagoons (north Italy), where one digenean species was the predominant enteric worm. All the helminths species induced a similar response, the hyperplasia of the intestinal mucous cells, particularly of those secreting acid mucins. Local endocrine signals seemed to affect the production and secretion of mucus in the parasitized fish, as worms often were surrounded by an adherent mucus layer or blanket. This is the first quantitative report of enteric worm effects on the density of various mucous cell types and on the mucus composition in intestine of infected/uninfected conspecifics. We provide a global comparison between the several fish-helminth systems examined.


Assuntos
Anguilla , Cyprinidae , Doenças dos Peixes/imunologia , Helmintíase Animal/imunologia , Truta , Acantocéfalos/fisiologia , Animais , Cestoides/fisiologia , Infecções por Cestoides/epidemiologia , Infecções por Cestoides/imunologia , Infecções por Cestoides/parasitologia , Infecções por Cestoides/veterinária , Doenças dos Peixes/epidemiologia , Doenças dos Peixes/parasitologia , Helmintíase Animal/epidemiologia , Helmintíase Animal/parasitologia , Mucosa Intestinal/parasitologia , Mucosa Intestinal/ultraestrutura , Itália/epidemiologia , Microscopia Eletrônica de Transmissão/veterinária , Prevalência , Trematódeos/fisiologia , Infecções por Trematódeos/epidemiologia , Infecções por Trematódeos/imunologia , Infecções por Trematódeos/parasitologia , Infecções por Trematódeos/veterinária
5.
Science ; 346(6213): 1080-4, 2014 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-25378461

RESUMO

Supermassive black holes with masses of millions to billions of solar masses are commonly found in the centers of galaxies. Astronomers seek to image jet formation using radio interferometry but still suffer from insufficient angular resolution. An alternative method to resolve small structures is to measure the time variability of their emission. Here we report on gamma-ray observations of the radio galaxy IC 310 obtained with the MAGIC (Major Atmospheric Gamma-ray Imaging Cherenkov) telescopes, revealing variability with doubling time scales faster than 4.8 min. Causality constrains the size of the emission region to be smaller than 20% of the gravitational radius of its central black hole. We suggest that the emission is associated with pulsar-like particle acceleration by the electric field across a magnetospheric gap at the base of the radio jet.

6.
Curr Oncol ; 16(6): 2-4, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20016739
7.
Phys Med ; 23(2): 67-72, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17568545

RESUMO

EBT radiochromic films were used to determine skin-dose maps for patients undergone Total Skin Electron Therapy (TSET). Gafchromic EBT radiochromic film is one of the newest radiation-induced auto-developing photon and electron-beam analysis films available for therapeutic radiation dosimetry in radiotherapy applications. EBT films can be particularly useful in TSET; due to patient morphology, underdosed regions typically occur, and the radiochromic film represents a suitable candidate for monitoring them. In this study, TSET was applied to treat cutaneous T-cell lymphoma. The technique for TSET was implemented by using an electron beam with a nominal energy of 6MeV. The patient was treated in a standing position using dual angled fields in order to obtain the greatest dose uniformity along the patient's longitudinal axis. The electron beam energy was degraded by a PMMA filter. The in vivo dose distribution was determined through the use of EBT films, as well as of thermoluminescent dosimeters for comparison (TLDs). EBT results showed a reasonable agreement with TLDs data.


Assuntos
Dermatopatias/radioterapia , Tomografia Computadorizada por Raios X/métodos , Elétrons/uso terapêutico , Humanos , Aceleradores de Partículas , Dosagem Radioterapêutica
8.
Radiat Prot Dosimetry ; 120(1-4): 216-20, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16717110

RESUMO

The effect of sample preparation on dentin electron paramagnetic resonance (EPR) spectra was investigated. The analysis was performed on dentin samples prepared by pure mechanical treatment or by an alkaline deproteination method. It was observed that (1) mechanical treatment induces both stable and transient signals, depending on the specific mechanical operation applied; and (2) sodium hydroxide deproteination removes the native signal, but at the same time introduces new confounding signals in the EPR spectrum. Also, it increases the radiation sensitivity of dentin. These findings suggest that attention must be paid to dentin sample preparation.


Assuntos
Dentina/química , Espectroscopia de Ressonância de Spin Eletrônica/métodos , Proteínas/química , Proteínas/isolamento & purificação , Humanos , Técnicas In Vitro
9.
Radiat Prot Dosimetry ; 120(1-4): 226-9, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16644956

RESUMO

In the implementation of a large-scale dosimetry intercomparison one of the main constraints is the availability of large number of dosemeters of the highest quality. Therefore, ISS tested the possibility of using commercially available dosemeters, alanine pellets and thermoluminescence (TL) dosimetry chips, for transfer dosimetry within the Italian intercomparison programme. In this work the characterisation of commercial alanine and TL dosemeters along with the ISS dose assessment procedure used in the Italian intercomparison are reported. Results demonstrate the feasibility of the ISS approach to transfer dosimetry since it is possible to measure 10 Gy with a combined uncertainty of 1% (1sigma) and 1 Gy with a combined uncertainty of 1.7% (1sigma) with alanine and TL dosemeters, respectively.


Assuntos
Alanina/química , Alanina/efeitos da radiação , Espectroscopia de Ressonância de Spin Eletrônica/instrumentação , Radioterapia/instrumentação , Dosimetria Termoluminescente/instrumentação , Relação Dose-Resposta à Radiação , Desenho de Equipamento , Análise de Falha de Equipamento , Humanos , Itália , Teste de Materiais , Dosagem Radioterapêutica , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
10.
Phys Med ; 22(3): 105-10, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-17664156

RESUMO

The Gafchromic XR type R film is a suitable dosimeter to determine the map of the skin dose in patients undergone complex interventional radiological procedures, such as cardiology ones. The need of preventing or locating possible skin injuries due to high doses administered to patients-as recommended by international organizations-wants the introduction in patient dosimetry of a dosimeter easy to handle, with low dependence of the response on energy in the typical radiological range, and extended measurable dose range. XR type R films fulfil all these requirements and moreover may be quickly analyzed by cheap commercial scanners. In order to determine skin-dose values by XR-R, a film calibration curve is required. In this work, validation of the XR-R dosimetry has been performed for the determination of the skin dose: maximum skin-dose values in 14 patients undergone radiofrequency ablation and pacemaker implant procedures have been determined by XR-R calibrated films. A comparison between skin-dose values determined by XR-R films and retrospective ionometric measurements has pointed out some discrepancies in the results, due to difficulties in retrospectively reproducing the real procedure settings, where XR-R film dosimetry is related to the specific patient procedure, even, in very complex interventional settings.

11.
Phys Med Biol ; 50(6): 1095-108, 2005 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-15798310

RESUMO

The aim of the present work was to investigate how the native signal observed in the electron paramagnetic resonance (EPR) spectrum of tooth enamel and dentin is associated with the organic content of the two tissues. This was achieved by comparing the EPR native signal and the optical bands (Raman and infrared, IR) associated with organic components of tooth enamel and dentin, in natural and deproteinated samples. The main results were: (a) in natural samples, the organic optical bands are more intense in dentin than in enamel, in contrast with the EPR native signal which shows similar intensity in the two tissues; (b) after deproteination, the optical organic bands are completely suppressed in both dentin and enamel, while the EPR native signal is eliminated only in dentin. It is suggested that the IR and Raman organic bands are originated in the bulk of the organic matrix, while the paramagnetic centres associated with the EPR native signal are located in the organic-mineral interface.


Assuntos
Esmalte Dentário/química , Dentina/química , Espectroscopia de Ressonância de Spin Eletrônica/métodos , Dente Molar/química , Proteínas/química , Espectrofotometria Infravermelho/métodos , Análise Espectral Raman/métodos , Humanos , Técnicas In Vitro
12.
Radiat Prot Dosimetry ; 110(1-4): 437-42, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15353687

RESUMO

Suitability of Electron Paramagnetic Resonance (EPR) spectroscopy for criticality dosimetry was evaluated for tooth enamel, mannose and alanine pellets during the 'international intercomparison of criticality dosimetry techniques' at the SILENE reactor held in Valduc in June 2002, France. These three materials were irradiated in neutron and gamma-ray fields of various relative intensities and spectral distributions in order to evaluate their neutron sensitivity. The neutron response was found to be around 10% for tooth enamel, 45% for mannose and between 40 and 90% for alanine pellets according their type. According to the IAEA recommendations on the early estimate of criticality accident absorbed dose, analyzed results show the EPR potentiality and complementarity with regular criticality techniques.


Assuntos
Espectroscopia de Ressonância de Spin Eletrônica/métodos , Raios gama , Nêutrons , Proteção Radiológica/métodos , Liberação Nociva de Radioativos , Radiometria/métodos , Medição de Risco/métodos , Carga Corporal (Radioterapia) , Espectroscopia de Ressonância de Spin Eletrônica/normas , França , Humanos , Reatores Nucleares , Variações Dependentes do Observador , Garantia da Qualidade dos Cuidados de Saúde/métodos , Doses de Radiação , Proteção Radiológica/normas , Radiometria/normas , Padrões de Referência , Eficiência Biológica Relativa , Reprodutibilidade dos Testes , Medição de Risco/normas , Fatores de Risco , Gestão da Segurança/métodos , Sensibilidade e Especificidade
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