RESUMO
El síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos o síndrome de DRESS según sus siglas en inglés (drug reaction with eosinophilia and systemic symptoms) se encuentra entre las reacciones medicamentosas cutáneas graves. Este consiste en una tríada clínica que incluye fiebre, exantema y compromiso sistémico, acompañado de eosinofilia y/o linfocitos atípicos.Se presenta el caso de una paciente de sexo femenino con fibrosis quística, de 18 meses de edad, quien desarrolló esta patología durante un tratamiento con trimetoprima-sulfametoxazol para erradicar Staphylococcus aureus meticilino resistente en esputo. Los pacientes con fibrosis quística reciben múltiples esquemas antibióticos según bacteriología en secreciones respiratorias para evitar el deterioro de la función pulmonar y colonización por gérmenes resistentes. Es menester conocer y sospechar este síndrome, debido al riesgo incrementado de hipersensibilidad a drogas en fibrosis quística, pronóstico ominoso y su elevada morbimortalidad
Drug reaction with eosinophilia and systemic symptoms or DRESS syndrome is among severe cutaneous drug reactions. This constitutes a clinical triad that includes fever, skin rash and systemic compromise, accompanied by eosinophilia and/or atypical lymphocytes.We present the case of an 18-month-old female patient with cystic fibrosis, who develops this pathology during a trimethoprim-sulfamethoxazole cycle as an eradicating treatment of methicillin-resistant Staphylococcus aureus in bronchial secretions. Cystic fibrosis patients receive multiple antibiotic regimens according to bacteriology in sputum, to avoid impairment in their lung function and colonization by resistant germs. Due to the increased risk of drug hypersensitivity in cystic fibrosis, an ominous prognosis and high morbidity and mortality, knowledge and a high index of suspicion of this syndrome are necessary
Assuntos
Humanos , Feminino , Lactente , Fibrose Cística , Síndrome de Hipersensibilidade a Medicamentos/diagnóstico , Staphylococcus aureus , Combinação Trimetoprima e Sulfametoxazol/efeitos adversos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Eosinofilia/diagnóstico , Síndrome de Hipersensibilidade a Medicamentos/complicaçõesRESUMO
Drug reaction with eosinophilia and systemic symptoms or DRESS syndrome is among severe cutaneous drug reactions. This constitutes a clinical triad that includes fever, skin rash and systemic compromise, accompanied by eosinophilia and/ or atypical lymphocytes. We present the case of an 18-month-old female patient with cystic fibrosis, who develops this pathology during a trimethoprim-sulfamethoxazole cycle as an eradicating treatment of methicillin-resistant Staphylococcus aureus in bronchial secretions. Cystic fibrosis patients receive multiple antibiotic regimens according to bacteriology in sputum, to avoid impairment in their lung function and colonization by resistant germs. Due to the increased risk of drug hypersensitivity in cystic fibrosis, an ominous prognosis and high morbidity and mortality, knowledge and a high index of suspicion of this syndrome are necessary.
El síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos o síndrome de DRESS según sus siglas en inglés (drug reaction with eosinophilia and systemic symptoms) se encuentra entre las reacciones medicamentosas cutáneas graves. Este consiste en una tríada clínica que incluye fiebre, exantema y compromiso sistémico, acompañado de eosinofilia y/o linfocitos atípicos. Se presenta el caso de una paciente de sexo femenino con fibrosis quística, de 18 meses de edad, quien desarrolló esta patología durante un tratamiento con trimetoprima-sulfametoxazol para erradicar Staphylococcus aureus meticilino resistente en esputo. Los pacientes con fibrosis quística reciben múltiples esquemas antibióticos según bacteriología en secreciones respiratorias para evitar el deterioro de la función pulmonar y colonización por gérmenes resistentes. Es menester conocer y sospechar este síndrome, debido al riesgo incrementado de hipersensibilidad a drogas en fibrosis quística, pronóstico ominoso y su elevada morbimortalidad.
Assuntos
Fibrose Cística , Síndrome de Hipersensibilidade a Medicamentos , Eosinofilia , Staphylococcus aureus Resistente à Meticilina , Antibacterianos , Criança , Fibrose Cística/complicações , Fibrose Cística/tratamento farmacológico , Síndrome de Hipersensibilidade a Medicamentos/diagnóstico , Síndrome de Hipersensibilidade a Medicamentos/etiologia , Feminino , Humanos , LactenteRESUMO
BACKGROUND: Infectious skin disorders (ISDs) are commonly seen in pediatric emergency departments (PED), however the exact frequency is unknown. We provide an accurate evaluation of the incidence and characteristics of ISDs diagnosed in a PED from Buenos Aires, Argentina, over a 1-year period. METHODS: Prospectively, descriptive study of children evaluated in the PED with ISDs during 2016. ISDs were analyzed on the basis of their incidence, patient demographics, seasonal variations, and hospitalization rates. RESULTS: ISDs were diagnosed in 1680 (67.9%) of the skin consultations (M/F: 1.1; mean age: 4.4 ± 3.7 years). Bacterial infections were observed in 932 (55.5%) cases. Viral infections were seen in 604 patients (35.9%). Fungal and parasite skin infections were diagnosed in 33 (2%) and 111 (6.6%) children, respectively. The most frequent ISDs according to the etiology group were impetigo 377 (22.4%), varicella 397 (23.6%), tinea capitis 10 (0.6%), and scabies 109 (6.5%). A higher frequency of ISDs were reported during the summer (38.4%) and spring (38.2%) months. Bacterial skin infections were more frequent during the summer months, while viral skin infections were more prevalent during spring. Parasitic skin infections were diagnosed more frequently during the winter months. No differences were seen for mycotic skin infections. Hospitalization rate was 1% (all for bacterial skin infections). CONCLUSION: Our data reveal the extremely high frequency of ISDs seen at the PED, underlying the need for closer cooperation between dermatologists and pediatricians.
Assuntos
Hospitalização/estatística & dados numéricos , Estações do Ano , Dermatopatias Infecciosas/epidemiologia , Dermatopatias Infecciosas/etiologia , Argentina/epidemiologia , Varicela/epidemiologia , Criança , Pré-Escolar , Serviço Hospitalar de Emergência , Feminino , Hospitais Pediátricos , Humanos , Impetigo/epidemiologia , Incidência , Lactente , Masculino , Estudos Prospectivos , Escabiose/epidemiologia , Centros de Atenção Terciária , Tinha do Couro Cabeludo/epidemiologiaRESUMO
El exantema periflexural asimétrico de la infancia es una entidad benigna, autolimitada, subdiagnosticada, de etiología desconocida, que compromete mayormente niñas de edad preescolar. Tiene predominancia estacional (invierno y primavera). Su diagnóstico es clínico, y se presenta como un exantema escarlatiniforme, morbiliforme o eccematoso, que generalmente comienza en la axila y se extiende centrífugamente hacia el tronco y el miembro superior homolateral. Puede acompañarse de adenopatías regionales y fiebre. No requiere tratamiento específico, salvo el uso de cremas humectantes y antihistamínicos, en caso de presentar prurito. Se describen 2 pacientes con diferentes formas de presentación de esta entidad, una típica y otra infrecuente.
Asymmetric periflexural exanthema of childhood is a benign, self-limited, underdiagnosed disease of unknown etiology that mainly affects girls at preschool age. It has seasonal predominance (winter and spring). The diagnosis is clinical and is presented as scarlatinform, morbiliform or eczematous exanthem that generally begins in the axilla and centrifugally extends to the trunk and the homolateral upper limb. It may be accompanied with regional adenopathies and fever. It does not require specific treatment except for the use of moisturizing and antihistaminic creams in case of pruritus. Two patients with different forms of presentation, one typical and another unfrequent, were described.