RESUMO
Se realizó una sistematización de la experiencia de: "círculos de la palabra" con líderes barriales del municipio de Villamaría, Caldas, Colombia entre 2016 y 2019, con base en los lineamientos de los autores: Jara, Ghiso y Verger. La experiencia permitió identificar tres hitos: "conocernos, el acompañamiento y los sueños", "sujetos de conocimiento" y "la experiencia construida socialmente". Los círculos de la palabra se configuraron para dar a los líderes de las comunidades un espacio donde tener voz y promover la reflexión movilizadora, construir tejidos y crear redes sociales de apoyo para conseguir un buen vivir.
A systematization of the experience titled: "word circles" with neighborhood leaders in Villamaría - Caldas (Colombia) between 2016 and 2019, was conduc ted based on Jara, Ghiso, and Verger guidelines. This experience allowed to iden tify three milestones: "getting to know each other, accompaniment and dreams," "subjects of knowledge," and "experience socially constructed". The word circles were created to provide to community leaders a place where they may have a voice and to foster mobilizing reflection, to build social fabric, and creating support networks to achieve a good life.
RESUMO
BACKGROUND AND AIMS: Costa Rica has among the highest incidence and mortality rates for gastric cancer worldwide. The reasons for this are largely unknown. Polymorphisms of inflammatory response genes including genes encoding heat shock proteins (HSP) have been shown to be associated with the risk of gastric cancer in some populations. This study addresses the possible association between the HSP70-2 +1267 and HSP70-Hom +2437 polymorphisms and the risk of developing gastric cancer in a high-risk population in Costa Rica. METHODS: DNA from 39 individuals diagnosed with gastric cancer, 79 healthy controls, 55 individuals with chronic gastritis and 52 individuals with duodenal ulcer was genotyped for the polymorphisms HSP70-2 +1267 and HSP70-Hom +2437 by RFLP. Logistic regression analysis was used to determine possible associations with the diagnoses and lineal regression analysis to determine associations with blood pepsinogen (PGs) levels as measured by serology. RESULTS: The GA genotype of HSP70-2 was associated with increased risk of gastric cancer (OR = 3.42; 95% CI = 1.27-9.21; p = 0.015) and duodenal ulcer (OR = 2.57; 95% CI = 1.03-6.36; p = 0.042) as compared to the GG genotype. Persons with C carrier genotypes of HSP70-Hom were significantly less susceptible to gastric cancer than those with the TT genotype (OR = 0.29; 95% CI = 0.09-0.87; p = 0.027). The C carrier genotype was associated with lower PGI concentrations but none of the polymorphisms were associated with PGI/PGII. CONCLUSIONS: Polymorphisms of HSP70 genes are associated with the development of gastric cancer and duodenal ulcers in a population at high risk for gastric cancer in Costa Rica.