1.
Org Lett
; 24(49): 8931-8935, 2022 12 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36331529
RESUMO
An efficient two-step procedure for the syntheses of pyrimidine nucleosides is presented. A series of glycosyl 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives were prepared from ß-anomeric isonitriles by reaction with Meldrum's acid or by allowing aminomethylene Meldrum's acid to react with an 1-aldofuranosyl halide or acetate. The resultant 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives underwent reaction with benzyl- or 2,4-dimethoxybenzyl isocyanate via transacylation to provide uridine-5-carboxylic acid derivatives and related nucleosides. These nucleoside carboxylic acids were converted into other C-5 derivatives by bromo-decarboxylation with N-bromosuccinimide.
Assuntos
Dioxanos , Nucleosídeos de Pirimidina , Uridina , Nucleosídeos
2.
Medicinal Chemistry in South America: From Tropical Diseases to Cancers and Other Major Afflictions.
ACS Med Chem Lett
; 12(9): 1350-1356, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34531941