Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Intervalo de ano de publicação
1.
Afr Health Sci ; 11 Suppl 1: S14-8, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22135637

RESUMO

BACKGROUND: F. hepatica infection is rare and mostly subclinical. Migration of juvenile forms of F. hepatica into the host's liver is accompanied by an inflammatory reaction followed by fibrosis and cirrhosis. OBJECTIVE: The aim of this study was to evaluate oxidative status by using a novel automated method in patients with Fasciola hepatica. METHODS: Twenty two patients with a diagnosis of F. hepatica and 26 healthy volunteers were enrolled in the study. Their Total antioxidant capacity status (TAC), total oxidant status (TOS) and catalase were measured in them and oxidative stress index (OSI) was calculated. These measurements were also taken for the control group and the values were compared. RESULTS: Plasma levels of total TOS and OSI were significantly increased in patients as compared with healthy controls (P<0.001, P<0.001, P=0.001, P=0.008) respectively. In contrast, TAC level was significantly lower in patients as compared with controls (p<0.05). There was no significant difference between the catalase results of the two groups (p>0.05). CONCLUSION: Total oxidative status and OSI were increased and total antioxidative status capacity was decreased in patients with F. hepatica infection. A high oxidative stress occurs during F. hepatica infection, which may cause severe damage in both the liver.


Assuntos
Fasciola hepatica , Fasciolíase/metabolismo , Estresse Oxidativo/fisiologia , Adolescente , Adulto , África , Animais , Criança , Pré-Escolar , Fasciolíase/fisiopatologia , Feminino , Humanos , Fígado/fisiopatologia , Masculino , Pessoa de Meia-Idade , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA