1.
MicroPubl Biol
; 20242024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38287927
RESUMO
Cellular processes rely on proteins with temperature-dependent stability and activity. While thermosensitivity in biological networks is well-explored, the effect of temperature on complex mechanochemical assemblies, like the spindle, is rarely studied. We examined fission yeast spindle dynamics and chromosome segregation from 15°C to 40°C. Our findings reveal that these parameters follow U-shaped temperature-dependent curves but reach their minima at different temperatures. Specifically, spindle dynamics peak around 35°C, whereas chromosome segregation defects are minimized at 25°C. This suggests a scenario in which mitotic errors are tolerated to expedite rapid cell cycle progression.