Secondary developmental glaucoma in eyes with congenital aphakia.

PURPOSE: To describe the clinical spectrum and management of glaucoma in congenital aphakia. METHODS: The demographics and clinical spectrum of eyes with congenital aphakia with and without glaucoma were compared, and management outcomes of congenital aphakia cases with glaucoma were studied retrospectively between April 2000 and June 2020. RESULTS: There were a total of 168 eyes (84 subjects) with a diagnosis of congenital aphakia, of which 29 eyes of 18 subjects were diagnosed with glaucoma. Corneal opacity was the presenting complaint in 26/29 eyes with glaucoma and 139/139 eyes without glaucoma. The (interquartile range (IQR)) horizontal corneal diameterwas 10.5mm (IQR, 9.0-12.5) and 8mm (IQR, 5-10) in eyes with and without glaucoma (P = 0.01), respectively. The median (IQR) axial length was 17.5mm (IQR, 13.5-19.5) and 15mm (IQR, 14-16) mm in eyes with and without glaucoma (P = 0.03), respectively. Nineteen eyes with glaucoma had adequate intraocular pressure (IOP) control with one medication. Three eyes underwent transscleral diode cyclophotocoagulation and maintained IOP without medications. Three eyes underwent trabeculectomy and trabeculotomy, trabeculectomy followed by penetrating keratoplasty, and trabeculectomy, respectively, of which two eyes became phthisical. At the last follow-up, the median (IQR) IOP was 14 mm Hg (IQR, 14-17) Hg. The median(IQR) follow-up duration was 4.53 months (IQR, 2.03- 48.06). CONCLUSION: One-fifth of the eyes with congenital aphakia had secondary developmental glaucoma. The corneal diameter and axial lengths were higher in the eyes with glaucoma compared to eyes without glaucoma. Medical management is the preferred short-term mode of IOP control. Transscleral cyclophotocoagulation may be preferred over surgical intervention.

Co-existing lacrimal drainage anomalies in eyes with congenital Glaucoma.

AIM: To evaluate the occurrence of co-existing congenital nasolacrimal duct obstruction (CNLDO) and other lacrimal anomalies in eyes with congenital glaucoma (CG). METHODS: Retrospective analysis of children aged ≤1-year with co-existing CG and CNLDO seen between 1998 and 2019, treatment interventions and outcomes. RESULTS: During the study period, 1993 children had CG and 6203 children had CNLDO, among the children aged 1-year or less. Of these, 51 children (73 eyes) had co-existing CG and CNLDO. The prevalence of CNLDO in CG was 2.5% (51/1993) and the prevalence of CG among CNLDO was 0.8% (51/6203). Median age (Interquartile range, IQR) was 53 days (IQR: 8, 155), when they were diagnosed with CG. Among the children with CNLDO, 68 eyes (93.1%) had simple CNLDO, and 5 eyes (6.9%) had complex CNLDO. Associated lacrimal anomalies were present in 7/73 eyes, including congenital lacrimal fistula in two eyes, upper punctal agenesis and upper mid-canalicular obstruction in two eyes each, and upper single canalicular-wall hypoplasia in one eye. Lacrimal syringing and probing were successful in 69/72 eyes (95.8%), and failed in 3 eyes (4.2%). These 3 eyes had complex CNLDO and underwent Dacryocystorhinostomy (DCR) with Mitomycin-C and intubation. Sixty-two eyes underwent combined trabeculotomy and trabeculectomy, and two eyes underwent trabeculectomy. Median age at glaucoma surgery was 87 days (IQR: 54, 193). Median time delay for glaucoma surgery after probing was 18 days (IQR: 12, 35). CONCLUSION: Among children aged ≤1-year presenting with congenital glaucoma coexisting lacrimal drainage anomalies was noted in 2.5% and simple CNLDO was the commonest. Early intervention is of paramount importance to prevent sight-threatening intraocular infection with CNLDO, and to minimize the delay of glaucoma surgery. The outcomes of lacrimal probing were excellent, however complex CNLDO required DCR.

Estimation of Goldmann applanation tonometer intraocular pressure (IOP) from scleral Schiotz IOP values in eyes with type-1 keratoprostheses.

PURPOSE: To validate estimation of Goldmann applanation tonometer (GAT) intraocular pressure (IOP) from scleral Schiotz IOP measurements using a regression model in normal eyes and eyes with type-1 keratoprostheses. METHODS: In this prospective cross-sectional study, cohort-1 had 253 normal anterior segment eyes, and cohort-2 had 100 eyes with type-1 keratoprostheses. Scleral Schiotz IOP measurements were used (in a non-linear model) to predict GAT IOP values for these eyes. Accuracy of predicted GAT IOP values was assessed using actual GAT IOP values for normal eyes, while for type-1 keratoprosthetic eyes, finger tension (FT) IOP assessments by an experienced glaucoma specialist were used. Primary outcome was agreement between FT IOP (assessed by an experienced glaucoma specialist) and predicted GAT IOP-derived clusters. RESULTS: The actual values of GAT IOP measurements in normal eyes (n=253; mean age ±SD, 51.35±15.56 years) ranged between 6 mm Hg and 62 mm Hg (mean=22±10.05 mm Hg). Estimated and actual GAT IOP values for normal eyes were very similar (mean difference=0.05 mm Hg with limits of agreement: -5.39 to 5.5 by Bland-Altman plot). Of the 100 eyes with type-1 keratoprostheses, 68 were classified as having digitally normal IOP, 28 as borderline and 4 as high. The agreement between classification by FT assessment and model-predicted GAT IOP values was substantial (Kappa=0.81, 95% CI 0.69 to 0.93). The accuracy of the model in assessing IOP was found to be 91% (95% CI 0.84 to 0.96). CONCLUSION: Scleral Schiotz IOP values along with our predictive model can be an alternative objective method to FT IOP in assessing IOP in eyes with type-1 keratoprostheses.

Trabeculectomy for neovascular glaucoma in proliferative diabetic retinopathy, central retinal vein occlusion, and ocular ischemic syndrome: Surgical outcomes and prognostic factors for failure.

PURPOSE: To evaluate the outcomes of trabeculectomy in the eyes with neovascular glaucoma (NVG), caused by proliferative diabetic retinopathy (PDR), central retinal vein occlusion (CRVO), and ocular ischemic syndrome (OIS). METHODS: A retrospective review of NVG eyes that underwent trabeculectomy between 1991 and 2019. Complete success was defined as intraocular pressure (IOP) between 6 and 21 mmHg without antiglaucoma medications (AGM). The risk factors were analyzed by Cox's proportional hazard model. RESULTS: The study included 100 eyes of 100 subjects with a mean age of 58 ± 9.8 years and a median follow-up of 1.27 years (interquartile range: 0.63, 2.27). The cause of NVG was PDR in 59 eyes (59%), CRVO in 25 eyes (25%), and OIS in 16 eyes (16%). Trabeculectomy with mitomycin-C was performed in 88 eyes and trabeculectomy in 12 eyes. The cumulative complete success probability of trabeculectomy in PDR was 50% (95% confidence interval [CI]: 38, 65) at 1 year, 8% (1, 46) at 3-5 years. In OIS, it was 64% (43, 96) from 1 to 5 years. In CRVO, it was 75% (59, 94) at 1 year, 45% (23, 86) from 2 to 5 years. The PDR was associated with a higher risk of surgical failure compared to OIS (P = 0.04) and CRVO (P = 0.004). Other significant risk factors were increasing age (P = 0.02), persistent neovascularization of iris (NVI) (P = 0.03), higher number of anti-vascular endothelial growth factor (VEGF) injections prior to trabeculectomy (P = 0.02), and delay in performing trabeculectomy (P = 0.02). CONCLUSION: Compared to CRVO and OIS, the eyes with NVG secondary to PDR had poor success with trabeculectomy. Older age, persistent NVI, need for a higher number of anti-VEGF injections, and delayed surgery were associated with a higher risk for trabeculectomy failure.

Agreement of Intraocular Pressure Measurement of Icare ic200 with Goldmann Applanation Tonometer in Adult Eyes with Normal Cornea.

PURPOSE: To study the agreement between the Icare ic200 (ICare Finland Oy, Helsinki, Finland) and the Goldmann Applanation Tonometer (GAT) in the measurement of intraocular pressure (IOP) in adult eyes. DESIGN: Noninterventional, cross-sectional study. PARTICIPANTS: A total of 156 eyes of 156 adult participants with clear corneas were included. METHODS: The IOP measurements were obtained with the Icare ic200 by 1 observer followed by GAT readings by a second masked observer. The central corneal thickness (CCT) and biometry of all subjects were recorded. MAIN OUTCOME MEASURES: The agreement between Icare ic200 and GAT was measured using the Bland-Altman plot. RESULTS: The mean age ± standard deviation of subjects was 55.3 ± 13.7 years. The GAT IOP ranged from 6 to 50 mmHg with a mean IOP of 19.5 ± 8.8 mmHg. The Icare ic200 IOP ranged from 7.4 to 50 mmHg with a mean IOP of 20.8 ± 9.3 mmHg. The mean difference between the IOP measurement of GAT and Icare ic200 was -1.27 mmHg with the 95% limits of agreement (LoA) ranging from -3.4 to 0.9 mmHg for all ranges of IOP. The mean difference (95% LoA) between the IOP measurement of GAT and Icare ic200 was -1 mmHg (-3 to 1 mmHg) and -1.8 mmHg (-4 to 0.2 mmHg) for a GAT IOP ≤21 mmHg and >21 mmHg, respectively. The CCT, axial length, age, and gender did not significantly affect the difference in measurement of IOP between the 2 tonometers. However, for every 1-mmHg increase in GAT IOP, the difference between the 2 tonometers increased by 0.04 mmHg (P < 0.001). CONCLUSIONS: In our study, the Icare ic200 overestimated the IOP. The overestimation increased as the baseline IOP increased. The agreement between the IOP measurement by GAT and Icare ic200 was <2 mmHg at all ranges of IOP. The narrow LoA between the tonometers for an IOP <21 mmHg makes it a useful alternative to GAT in this pressure range.

Agreement of Intraocular Pressure Measurement of Icare ic200 with Goldmann Applanation Tonometer in Adult Eyes with Normal Cornea.

PURPOSE: To study the agreement between the Icare ic200 (ICare Finland Oy, Helsinki, Finland) and the Goldmann Applanation Tonometer (GAT) in the measurement of intraocular pressure (IOP) in adult eyes. DESIGN: Noninterventional, cross-sectional study. PARTICIPANTS: A total of 156 eyes of 156 adult participants with clear corneas were included. METHODS: The IOP measurements were obtained with the Icare ic200 by 1 observer followed by GAT readings by a second masked observer. The central corneal thickness (CCT) and biometry of all subjects were recorded. MAIN OUTCOME MEASURES: The agreement between Icare ic200 and GAT was measured using the Bland-Altman plot. RESULTS: The mean age ± standard deviation of subjects was 55.3 ± 13.7 years. The GAT IOP ranged from 6 to 50 mmHg with a mean IOP of 19.5 ± 8.8 mmHg. The Icare ic200 IOP ranged from 7.4 to 50 mmHg with a mean IOP of 20.8 ± 9.3 mmHg. The mean difference between the IOP measurement of GAT and Icare ic200 was -1.27 mmHg with the 95% limits of agreement (LoA) ranging from -3.4 to 0.9 mmHg for all ranges of IOP. The mean difference (95% LoA) between the IOP measurement of GAT and Icare ic200 was -1 mmHg (-3 to 1 mmHg) and -1.8 mmHg (-4 to 0.2 mmHg) for a GAT IOP ≤21 mmHg and >21 mmHg, respectively. The CCT, axial length, age, and gender did not significantly affect the difference in measurement of IOP between the 2 tonometers. However, for every 1-mmHg increase in GAT IOP, the difference between the 2 tonometers increased by 0.04 mmHg (P < 0.001). CONCLUSIONS: In our study, the Icare ic200 overestimated the IOP. The overestimation increased as the baseline IOP increased. The agreement between the IOP measurement by GAT and Icare ic200 was <2 mmHg at all ranges of IOP. The narrow LoA between the tonometers for an IOP <21 mmHg makes it a useful alternative to GAT in this pressure range.

Schiotz Scleral Intraocular Pressure Readings Predict Goldmann Applanation Readings Better Than Rebound Tonometry.

PURPOSE: To study the agreement between scleral intraocular pressure (IOP) measurements using the Schiotz, Icare, and Icare PRO tonometers versus Goldmann applanation tonometer (GAT) in eyes with nonscarred corneas. METHODS: This cross-sectional study included 83 eyes of 55 subjects. The order of IOP estimation was the corneal GAT, followed by ICare, ICare PRO, and Schiotz on the corneal and temporal sclera. The agreement between different tonometers and the 95% limits of agreement (LoA) were assessed using Bland-Altman plots. The repeated measures correlation coefficient was calculated between GAT IOP and scleral Schiotz IOP, and the 95% confidence intervals were calculated by the bootstrap method. The linear mixed effects model was used (adjusted for both eyes of the subjects) to generate an equation to predict GAT IOP from scleral Schiotz IOP. The prediction model was validated with new data from 60 eyes. Statistical analyses were performed using "R" software (version 3.3.2). RESULTS: Comparing the scleral IOP measurements, the mean IOP difference (95% LoA) was the lowest with Schiotz, underestimating by -1.21 mm Hg (7.32, -9.74). Both ICare and ICare PRO significantly overestimated GAT IOP: ICare, 24.6 mm Hg (53.2, -3.97); and ICare PRO, 21.56 mm Hg (52.9, -9.79). The correlation coefficient between scleral Schiotz and GAT IOP was 0.92 (95% bootstrap confidence interval: 0.89, 98). The derived predictive equation was (Equation is included in full-text article.). The mean difference between the predicted GAT IOP and the actual GAT IOP was 0.96 mm Hg with narrow LoA (+1.79, -3.71), validating the prediction model. CONCLUSIONS: Among the tonometers tested, the scleral IOP measurements with Schiotz had the best agreement with the GAT although LoA were wide. The predictive equation may have great potential to predict GAT IOP from scleral IOP readings in eyes with scarred/prosthetic corneas.