Disaggregating within- and between-person associations to test the aversive transmission of alcohol use in late adolescence through adulthood.

OBJECTIVE: The theory of aversive transmission posits that children of parents who have an alcohol use disorder (AUD) may abstain or limit their own alcohol use because they believe themselves to be at risk of developing problems with alcohol. The present study examined relationships among parental AUD, perceived parental AUD, perceived risk for AUD, addiction avoidance reasons for limiting alcohol use, and alcohol use using a random intercept cross-lagged panel model. METHOD: Participants (N = 805; 48% female; 28% Latinx) were from a longitudinal study investigating intergenerational transmission of AUD. Parental AUD, perceived parental AUD, perceived risk for AUD, addiction avoidance reasons for limiting alcohol use, and alcohol use (quantity, frequency, and frequency of heavy drinking) were measured every 5 years from late adolescence (Mage = 20) to adulthood (Mage = 32). Random intercept cross-lagged panel models tested whether there were stable between-person relations or time-varying within-person relations among these variables. RESULTS: At the between-person level, perceived parental AUD predicted greater addiction avoidance reasons for limiting alcohol use and greater perceived risk. Those with greater addiction avoidance reasons for limiting alcohol use were less likely to use any alcohol and drank less frequently. Parental AUD was associated with higher levels of alcohol use as well as perceived risk. No consistent cross-lagged paths were found at the within-person level. CONCLUSIONS: Study findings were at the between-person level rather than the within-person level. Future work on aversive transmission is needed to better understand this subgroup of children of parents with AUD. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Understanding alcohol use and alcohol use disorders from a developmental psychopathology perspective: Research advances, challenges, and future directions.

As part of the special issue of Development and Psychopathology honoring the remarkable contributions of Dr Dante Cicchetti, the current paper attempts to describe the recent contributions that a developmental psychopathology perspective has made in understanding the development of alcohol use and alcohol-related problems over the lifespan. The paper also identifies some of the future challenges and research directions. Because the scope of this task far exceeds the confines of a journal length article this paper does not attempt a comprehensive review. Rather, it builds on an earlier review and commentary that was published in Development and Psychopathology in 2013, with a similar goal.)Building on that work and updating its conclusions and suggestions for future directions, the current paper emphasizes findings from the research areas that were identified for further study in 2013 and the findings that have been published since that time.

Heritable Composite Phenotypes Defined by Combinations of Conduct Problem, Depression, and Temperament Features: Contributions to risk for Alcohol Problems.

The genetic architectures underlying symptoms of conduct problems and depression have largely been examined separately and without incorporating temperament, despite evidence for their genetic overlap. We examined how symptoms and temperament dimensions were transmitted together in families to identify highly heritable composite phenotypes, and how these composite phenotypes predicted alcohol outcomes in young adulthood. Participants (N = 486) were drawn from the third generation of families oversampled for alcohol use disorder in the first generation. Conduct problems, depression, and temperament were reported at 11-19 years old and alcohol outcomes at 18-26 years old. Using principal components of heritability analysis, we found seven highly heritable composite phenotypes, five of which predicted alcohol outcomes: three characterized by co-occurring conduct problems and depression and two by conduct problems. Novel composite phenotypes that were characterized by both conduct problems and depression showed different types of symptoms, temperament features, and genetic underpinnings. Children manifesting differing composite phenotypes might benefit from distinct treatments based on their unique etiologies.

Longitudinal Relations Among Parental Substance Use Disorder and Adolescent Drinking Behavior: The Role of Temperament, Negative Urgency, and Maternal Parenting.

Research suggests that parental substance use disorder is associated with adolescent drinking indirectly through negative urgency, a form of impulsivity that is particularly associated with high-risk drinking. Moreover, childhood mechanisms of risk may play a role in this developmental chain such that childhood temperament and parenting may be mechanisms through which parental substance use disorder is associated with adolescent negative urgency and drinking behavior. Therefore, the current study tested whether parental substance use disorder was indirectly associated with adolescent drinking frequency through childhood temperament (i.e., "dysregulated irritability") and adolescent negative urgency, and whether relations differed by levels of maternal support and consistency of discipline. Data come from a multigenerational, longitudinal study of familial substance use disorder (N = 276, Mage in childhood = 6.28 (SD = 1.16), Mage in adolescence = 15.86 (SD = 1.56), 45.3% female). Findings indicated that parental substance use disorder indirectly predicted adolescent drinking through both childhood dysregulated irritability and adolescent negative urgency (mediated pathways). This indirect relation was stronger at higher vs. lower levels of maternal support but did not vary by maternal consistency of discipline. Parental substance use disorder also indirectly predicted adolescent drinking separately through childhood dysregulated irritability and negative urgency. Findings thus suggest that childhood dysregulated irritability may be an early marker of risk toward high-risk personality traits and behavior in adolescence that are associated with having a parental history of substance use disorder. Findings also suggest that increased maternal support may only be helpful in buffering risk for those with low levels of dysregulated irritability. Prevention efforts focused on childhood emotion regulation and emotion-based action may be useful in preventing adolescent risk behavior.

Parent-child separation and intergenerational transmission of substance use and disorder: Testing across three generations.

There is evidence for intergenerational transmission of substance use and disorder. However, it is unclear whether separation from a parent with substance use disorder (SUD) moderates intergenerational transmission, and no studies have tested this question across three generations. In a three-generation study of families oversampled for familial SUD, we tested whether separation between father (G1; first generation) and child (G2; second generation) moderated the effect of G1 father SUDs on G2 child SUDs. We also tested whether separation between father (G2) and child (G3; third generation) moderated the effect of G2 SUDs on G3 drinking. Finally, we tested whether G1-G2 or G2-G3 separation moderated the mediated effect of G1 SUDs on G3 drinking through G2 SUDs. G1 father-G2 child separation moderated intergenerational transmission. In families with G1-G2 separation, there were no significant effects of father SUD on G2 SUD or G3 drinking. However, in nonseparated families, greater G1 father SUDs predicted heightened G2 SUDs and G3 grandchild drinking. In nonseparated families, G1 father SUDs significantly predicted G2 SUDs, which predicted G3 drinking. However, G2-G3 separation predicted heightened G3 drinking regardless of G2 and G1 SUDs. Parental separation may introduce risk for SUDs and drinking among youth with lower familial risk.

Grandparent alcohol use disorder and grandparent-grandchild relationships.

Involvement of grandparents in grandchildren's lives is important for grandchild well-being. Studies suggest that the quality of relationships between grandparents and their adult children may "spill over" to the quality of their relationships with their grandchildren. However, no research has tested whether grandparent alcohol use disorder (AUD) disrupts intergenerational relationships. This is important because grandchildren may not benefit from closeness with grandparents with AUD. In a sample of 295 parents and their children (N = 604) from a larger longitudinal study oversampled for familial AUD, this study tested whether grandparents (G1, "Generation 1") with AUD had poorer relationships with their adult children (G2 "Generation 2") in terms of greater stress and less support provided and less closeness with their grandchildren (G3, "Generation 3"). We also tested whether poorer G1-G2 relationship quality predicted less G1-G3 closeness. Finally, we tested whether effects of G1 AUD on G1-G3 closeness were explained by G1-G2 relationship quality. Separate models were estimated for maternal and paternal grandparents. We found evidence for three indirect effects. First, G1 maternal grandparent AUD predicted greater stress in the G1 grandmother-G2 mother relationship, which was associated with greater closeness between maternal grandmothers and grandchildren. This indirect effect was replicated in G1 paternal grandfathers and G2 fathers. Additionally, G1 paternal grandparent AUD was associated with lower levels of support provided from G1 grandfathers to G2 fathers, which predicted less closeness between paternal grandfathers and grandchildren. The results demonstrate complex intergenerational effects of AUD on family relationships and consistent with the hypothesized "spillover" effect of intergenerational relationships. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Multilevel longitudinal relations among impulsive traits, positive expectancies, and binge drinking from late adolescence to adulthood: A developmental test of acquired preparedness.

BACKGROUND: The Acquired Preparedness Model (APM) posits that highly impulsive individuals develop stronger positive alcohol expectancies, which in turn predicts heavier drinking. However, most acquired preparedness studies have focused solely on between-person relations, despite the theory suggesting that there are potential developmental-specific within-person relations. Thus, the current study tested the APM from late adolescence into adulthood, while disaggregating within- from between-person relations. METHODS: Data come from a multigenerational study of familial alcohol use disorder (N=653) spanning three waves 5 years apart. Participants reported their lack of conscientiousness, sensation seeking, positive alcohol expectancies, and binge drinking at each wave. First, missing data techniques were used to create a "ghost timepoint," allowing the specification of four developmental-specific timepoints representing late adolescence (age 18 to 20), emerging adulthood (age 21 to 25), young adulthood (age 26 to 29), and adulthood (age 30 to 39). Second, a Random-Intercept Cross-Lagged Panel Model tested between-person and within-person relations among variables. RESULTS: At the between-person level, lower conscientiousness and sensation seeking were correlated with higher positive expectancies, and positive expectancies were correlated with more binge drinking. There were no within-person prospective relations among conscientiousness, sensation seeking, and positive expectancies. However, within-person increases in lack of conscientiousness during late adolescence predicted within-person increases in emerging adult binge drinking, and within-person increases in late adolescent and emerging adult binge drinking predicted within-person increases in lack of conscientiousness during emerging and young adulthood, respectively. Similarly, within-person increases in late adolescent and young adult sensation seeking predicted within-person increases in binge drinking during emerging adulthood and adulthood, respectively. Binge drinking did not reciprocally predict sensation seeking. CONCLUSIONS: Findings suggest that acquired preparedness effects may be between persons rather than within persons. However, several within-person developmental-specific relations among conscientiousness, sensation seeking, and binge drinking were observed, outside of expectancies. Findings are discussed in terms of theory and prevention.

A gene-environment cascade theoretical framework of developmental psychopathology.

Previous theories have emphasized genetic effects "inside the skin" via endophenotypes within the broader developmental psychopathology theory. Expanding on the mechanisms of gene-environment correlation, we propose a new integrative framework emphasizing how genetic effects "outside the skin" (Reiss & Leve, 2007) accumulate due to individual variation in social information processing in negative environments and sociocultural contexts as part of developmental cascades to psychopathology. In this gene-environment cascade theoretical framework, genetic predisposition for psychopathology, as well as stable traits and behaviors, can lead to negative environments via gene-environment correlations that can be exacerbated or buffered by an individual's social information processing. Moreover, these "environments" range from dyadic social relationships to broader sociocultural contexts. Over time, these processes exacerbate one another as part of developmental cascades, resulting in accumulating risk for psychopathology. By focusing on gene-environment correlations and integrating disparate social-emotional, cognitive, and sociocultural research domains, this framework delineates key processes by which early genetic predisposition can contribute to developmentally distinct and accumulating risk for psychopathology over the life course. Implications for intervention and methodological advances that facilitate testing models are presented. This new framework moves the field further away from genetic determinism by informing targets of early psychosocial prevention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

A life span developmental investigation of marriage and problem-drinking reduction.

While prior literature has largely focused on marriage effects during young adulthood, it is less clear whether these effects are as strong in middle adulthood. Thus, we investigated age differences in marriage effects on problem-drinking reduction. We employed parallel analyses with two independent samples (analytic-sample Ns of 577 and 441, respectively). Both are high-risk samples by design, with about 50% of participants having a parent with lifetime alcohol use disorder. Both samples have been assessed longitudinally from early young adulthood to the mid-to-late 30s. Separate parallel analyses with these two samples allowed evaluation of the reproducibility of results. Growth models of problem drinking tested marriage as a time-varying predictor and thereby assessed age differences in marriage effects. For both samples, results consistently showed marriage effects to be strongest in early young adulthood and to decrease somewhat monotonically thereafter with age, reaching very small (and nonsignificant) magnitudes by the 30s. Results may reflect that role transitions like marriage have more impact on problem drinking in earlier versus later adulthood, thereby highlighting the importance of life span developmental research for understanding problem-drinking desistance. Our findings can inform intervention strategies aimed at reducing problem drinking by jumpstarting or amplifying natural processes of adult role adaptation.

Maturing out of alcohol and cannabis co-use: A test of patterns and personality predictors.

OBJECTIVE: Reductions in substance involvement into adulthood are thought to represent a normative maturing out of substance use. However, patterns and predictors of maturing out of alcohol and cannabis co-use remain largely unstudied. Therefore, the current study tested developmental trajectories of alcohol and cannabis use from late adolescence into adulthood and whether late adolescent personality traits predicted trajectory class membership. METHODS: Data come from a longitudinal study of family history of alcohol disorder (N = 458). Age bands were created to model trajectories of drinking quantity, negative alcohol consequences, and cannabis use frequency from late adolescence (age 18-22) to young adulthood (age 23-28) and adulthood (age 29-36). Participants reported on their sensation seeking, conscientiousness, and neuroticism during late adolescence and their typical drinking quantity, negative alcohol consequences, and cannabis use frequency at each age band. RESULTS: Three trajectory classes were derived from an initial Parallel Process Growth Mixture Model: (1) low-risk maturing out of alcohol-only use, (2) high-risk maturing out of co-use, and (3) high-risk switchers who increased their cannabis use into adulthood. Late adolescent sensation seeking was associated with higher odds of being in both co-use trajectories, whereas a lack of conscientiousness was associated with higher odds of being a co-use switcher. CONCLUSIONS: We identified heterogeneity in trajectories of co-use, which suggests that a lack of maturing out of alcohol involvement may be accompanied by increased cannabis use. Moreover, late adolescent personality traits may predispose individuals toward riskier developmental trajectories of substance use into adulthood.

Multidimensional Impulsive Personality Traits Mediate the Effect of Parent Substance Use Disorder on Adolescent Alcohol and Cannabis Use.

Theory suggests that behavioral undercontrol mediates the effect of parental substance disorder on offspring substance use, but no studies have tested multidimensional impulsive personality traits as mechanisms of risk. Adolescents (N = 392; 48% female) from a multigenerational study of familial alcohol disorder self-reported impulsive personality traits via the UPPS-P (Mage = 16.09; Range = 13-19) and alcohol/cannabis frequency one year later. The UPPS-P assesses negative and positive urgency (i.e., rash action in a negative or positive mood state), lack of premeditation (i.e., lack of planning/forethought), lack of perseverance (i.e., inability to finish tedious/boring tasks), and sensation seeking (i.e., thrill seeking/risk taking). Parent substance disorder was assessed via diagnostic interviews. Two-part hurdle models tested predictors of any substance use (i.e., binary part) and frequency of use (i.e., continuous part). Parent substance disorder was indirectly associated with any alcohol/cannabis use (binary part) and higher cannabis frequency (continuous part) through negative urgency. Parental substance disorder was associated with higher alcohol frequency through a lack of premeditation. Sensation seeking was associated with any alcohol/cannabis use but unrelated to parental substance disorder. Despite indirect effects, strong effects of parental substance disorder on substance use remained. The findings are discussed in terms of theory and public health implications.

Heterogeneity in effects of parent-child separation on young-adult substance use disorder.

A large body of literature suggests that parent-child separation predicts child maladjustment. However, further advancement in methodology is needed to account for heterogeneity in types of separation. Additionally, given a lack of research examining different types of separation as predictors of offspring substance use, further research into this topic is warranted. The present study tested the relation between parent-child separation and young-adult substance use disorder (SUD), capturing heterogeneity in these effects based on group differences and measurement of separation. In a sample of 427 young adults from a larger longitudinal study oversampled for parental alcohol use disorder (AUD), effects of number and type of separations on SUD diagnosis were tested. Further, we explored whether these associations were moderated by gender, ethnicity, or parental AUD. Two underlying types of separation were found: parental health-related separation (i.e., parental death, hospitalization) and nonhealth-related separation (i.e., divorce, arrest). A higher sum of separations and greater nonhealth-related separation predicted higher odds of SUD. Greater health-related separation predicted lower odds of SUD. However, these effects were qualified by interactions with ethnicity and parental AUD. Although the vast majority of studies measure cumulative parent-child separation with sum scores, the present study demonstrates that measuring underlying "types" of cumulative separation also reveals important effects. Moreover, childhood separation is a significant risk factor for SUD. Future research on separation should implement methods to capture separation types and further account for potential effects of selection into separation types. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

The prospective interactive effects of alcohol expectancies and subjective response on future drinking behavior.

Although alcohol expectancies and subjective response are independent predictors of drinking, social-cognitive theory suggests that expectancies may distort one's subjective response, creating discrepancies between expected and actual alcohol effects. A recent cross-sectional study found that unmet expectancies (using difference scores) were associated with heavier drinking. However, cross-sectional data cannot establish temporal precedence, and using difference scores ignores important conditional main effects. As such, the current study sought to evaluate how expectancy-subjective response discrepancies predict future drinking using prospective data and an interaction approach. Participants (N = 258) were randomly assigned to consume alcohol (target BAC = .08%) within a placebo-controlled alcohol administration session. Alcohol expectancies and subjective response were assessed across the full valence by arousal affective space using parallel measures. Results indicated a significant high arousal positive (HIGH+) interaction, such that, as HIGH+ expectancies increased, individuals at low and mean levels of HIGH+ subjective response drank more heavily 12 months later. There was also a significant high arousal negative (HIGH-) interaction with a similar pattern of moderated effects. No interactions were found for low arousal effects. These results indicate that individuals with unmet HIGH+ and HIGH- expectancies drink more heavily 12 months later, controlling for prior drinking. This suggests that clinicians may consider recommending specific interventions (e.g., expectancy challenges vs. pharmacotherapy) based upon an individual's levels of expectancies and subjective response to optimize intervention efficacy. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Neural bases of risky decisions involving nicotine vapor versus monetary reward.

Substantial effort has gone into neuroimaging studies of neural mechanisms underlying addiction. Human studies of smoking typically either give monetary reward during an fMRI task or else allow subjects to smoke outside the scanner, after the session. This raises a fundamental issue of construct validity, as it is unclear whether the same neural mechanisms process decisions about nicotine that process decisions about money. To address this, we developed a novel MR-compatible nicotine vaping device, such that access to nicotine vapor could be controlled and monitored. We recruited heavy smokers (Money: 45 subjects, 13 females and 32 males; Nicotine: 21 subjects, 4 females and 17 males) to perform a gambling task with nicotine and monetary reward on separate days. We collected BOLD fMRI data while they performed the task inside the scanner and analyzed it using general linear modeling, with inference based on cluster-size correction. This allowed a direct comparison between the neural mechanisms of choosing and receiving immediate drug vs. monetary reward. We found substantial differences in the neural mechanisms that underlie risky choices about money vs. drug reward, including a reversal of the well-known error effects in the medial prefrontal cortex.

Do Alcohol Consequences Serve as Teachable Moments? A Test of Between- and Within-Person Reciprocal Effects From College Age to Adulthood.

OBJECTIVE: Several studies find between-person reciprocal relations between adolescent/college drinking and positive expectancies. However, drinking and expectancies from college into adulthood are largely unstudied, as are within-person associations. During these age periods, negative alcohol consequences may represent "teachable moments" via expectancy change. The current study tested the reciprocal effects of drinking, negative consequences, and expectancies from college age to adulthood. METHOD: Using data from a longitudinal study focused on familial alcohol disorder, age bands were created to model effects from college age (18-22) to young adulthood (23-28) and adulthood (29-34). Participants (N = 420) reported on their drinking, negative consequences, and expectancies across three waves (1995-2010). RESULTS: Negative consequences did not predict negative expectancies, but the random intercepts of the two were highly related. Young adult negative consequences predicted a within-person increase in adult heavy drinking. A within-person increase in college age negative expectancies indirectly predicted a within-person decrease in adult negative consequences through reduced young adult drinking, whereas within-person increases in college age positive expectancies indirectly predicted a within-person increase in adult negative consequences through heavier young adult drinking. CONCLUSIONS: Findings suggest that negative consequences were related to trait-level negative expectancies, even though prospective effects were not observed. Findings also suggest that college age negative expectancies were protective against future use and consequences, and this effect was unique to college age.

Relations between impulsive personality traits, alcohol and cannabis co-use, and negative alcohol consequences: A test of cognitive and behavioral mediators.

OBJECTIVE: Alcohol and cannabis co-users experience more negative alcohol consequences, but distal and mediating mechanisms of this association remain largely unstudied. Considering research suggests that individuals high in impulsivity and sensation seeking are more likely to be co-users, it is possible that co-users have more positive expectancies and become heavier drinkers, which confer risk for future negative consequences. Therefore, the current study tested prospective mediation models in which impulsive personality traits indirectly predicted negative consequences through co-use, heavier drinking, and expectancies. METHODS: The current study used data from a study of familial AUD spanning 3 waves (1995-2010). Participants (N = 567) reported on impulsivity (via the Eysenck Personality Inventory and Sensation Seeking Scale) alcohol and cannabis use, alcohol expectancies, and negative consequences. Models tested the factor structure of impulsive personality traits and whether these traits predicted future negative consequences through past-year co-use and drinking/expectancies. RESULTS: Factor analysis suggested two factors, sensation seeking and lack of premeditation. Sensation seeking was associated with future negative consequences indirectly through co-use and both drinking quantity and positive expectancies. Lack of premeditation was not associated with co-use, but indirectly predicted negative consequences through positive expectancies, above and beyond co-use. Sensation seeking directly predicted negative expectancies, but negative expectancies did not predict negative consequences. CONCLUSIONS: Impulsive personality traits in co-users, particularly sensation seeking, explained variance in future negative alcohol consequences via heavier drinking (behavior) and positive expectancies (cognition). Personalized interventions targeting a lack of premeditation, and sensation seeking in co-users, may interrupt a developmental trajectory toward problem drinking.

Relations Between Child Temperament and Adolescent Negative Urgency in a High-Risk Sample.

Negative urgency, rash action during negative mood states, is a strong predictor of risky behavior. However, its developmental antecedents remain largely unstudied. The current study tested whether childhood temperament served as a developmental antecedent to adolescent negative urgency. Participants (N=239) were from a longitudinal study oversampled for a family history of alcohol use disorder (AUD). Negative emotionality (anger and sadness reactivity) and effortful control were measured in childhood (5-8) and negative urgency in adolescence (13-18). Childhood anger reactivity was uniquely related to later negative urgency above and beyond sadness reactivity. Effortful control was not related to later negative urgency; however, a latent variable capturing the shared variance between childhood effortful control and anger reactivity was related to later negative urgency.

Adolescent executive cognitive functioning and trait impulsivity as predictors of young-adult risky drinking and alcohol-related problems.

Executive cognitive functioning (ECF) and trait impulsivity have long been implicated in risky drinking and alcohol-related problems. However, research on these constructs has developed independently. The present study tested whether two subdomains of adolescent ECF (updating and response inhibition) and adolescent trait impulsivity, considered separately and together, predicted young-adult risky drinking and alcohol-related problems. Data came from the Adolescent/Adult Family Development Project-a longitudinal study of the intergenerational transmission of alcohol use. Alcohol-naïve youth ages 11-17 (N = 249) completed three tasks tapping ECF subdomains of updating (letter-number sequencing, matrix span task) and inhibition (immediate memory task) and a self-reported measure of trait impulsivity (UPPS-P). Approximately 7 years later (ages 18-25), participants reported on their drinking behavior (maximum drinks in a day, heavy episodic drinking, alcohol-related problems). We tested whether adolescent ECF and trait impulsivity predicted young-adult drinking outcomes, separately and together. Results showed that poorer adolescent ECF (a latent factor) predicted more maximum drinks in a day (Incidence Rate Ratios [IRR] = 1.27, p = .001) but not young-adult heavy episodic drinking and alcohol-related problems. In contrast, adolescent trait impulsivity predicted all three outcomes: maximum drinks in a day (IRR = 1.34, p < .001), heavy episodic drinking (ß = 0.27, p < .001), and alcohol-related problems in young adulthood (IRR = 1.60, p = .001). Results were similar when adolescent ECF and trait impulsivity were considered together in the same model. Findings suggest that adolescent trait impulsivity is a robust predictor of young-adult risky drinking and alcohol-related problems. Adolescent ECF, and specifically response inhibition, may add predictive value over and above trait impulsivity for some alcohol outcomes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Alcohol Use Disorder and Parental Alcohol Use Disorder as Predictors of Reproductive Timing.

OBJECTIVE: Research suggests associations between adolescent alcohol use and early reproduction, but other findings show that alcohol use disorder (AUD) may actually predict delayed reproduction. However, most studies generally do not consider the effects of parental AUD, which is correlated with AUD and may influence reproductive timing. The present study addressed these gaps by testing whether the individual's own AUD and parental AUD interacted with sex to predict reproductive timing. METHOD: In a longitudinally followed community sample that oversampled familial alcohol disorder (n = 776), multinomial logistic regressions estimated the effects of predictors on early (i.e., adolescent), delayed (age 25 years or later), and no reproduction, thus comparing the odds of each timing category to typical age of reproduction (i.e., 19-24 years of age). RESULTS: There were no interactions between either individual or parental AUD and sex, so interaction terms were trimmed. Individuals with parental AUD were more likely to reproduce early, but there was no effect of AUD on early reproduction. However, those with AUD were more likely to have delayed reproductive timing or no children. CONCLUSIONS: AUD and parental AUD are unique predictors of reproductive timing. Parental AUD was associated with early reproduction. Children of parents with AUD may be vulnerable to sexual risk behaviors in adolescence regardless of their own AUD diagnosis, given the constellation of personality and environmental risk factors associated with parental AUD. In contrast, replicating prior findings, AUD was associated with delayed reproduction and the absence of reproduction. AUD may delay reproductive onset through either biological or psychosocial mediators, such as delays in role transitions.

Maternal Influences on Effortful Control in Adolescence: Developmental Pathways to Externalizing Behaviors.

Adolescents' effortful control is subject to numerous maternal influences. Specifically, a mother's own effortful control is associated with her child's effortful control. However, maternal substance use, psychopathology, and stress within the parenting role may also lead to poor effortful control for their child. Poor effortful control during adolescence can subsequently contribute to a variety of negative outcomes, including externalizing behaviors. A sample of 460 adolescents (47% female, 59.3% Non-Hispanic Caucasian) was selected from a longitudinal, multigenerational study. The goal was to examine maternal effortful control, substance use, psychopathology, and stress in their offspring's childhood (Mage = 6.27) and their influence on their children's effortful control in early adolescence (Mage = 12.21) and the subsequent effect of effortful control on adolescents' externalizing behavior (Mage = 13.53). Maternal effortful control (measured via conscientiousness) and psychopathology were associated with adolescent effortful control, which was associated with externalizing behavior a year later. Additionally, there was a significant indirect association between maternal effortful control and adolescent externalizing behaviors via adolescent effortful control. Thus, adolescent effortful control is associated with maternal effortful control but also subject to specific maternal risk factors in childhood. These results inform potential maternal strategies for promoting positive developmental outcomes in adolescents.