Gender differences in the association between physical frailty and life satisfaction among older adults in India.

BACKGROUND: One of the sustainable development goals' (SDGs) primary goals (Goal 3) is to ensure healthy lives and promote well-being for persons of all ages. While extensive literature documents the link between physical frailty and low life satisfaction (LLS) among older adults, research of this nature is limited within low and middle-income countries including India. The purpose of this study was to examine the association between physical frailty and life satisfaction among community-dwelling older men and women in India. METHODS: Data come from the 2017-18 wave 1 of the Longitudinal Ageing Study in India (LASI), with a sample of 30 390 individuals aged 60 and above (14 559 men and 15 831 women). Physical frailty was assessed using an adapted version of the frailty phenotype developed by Fried and colleagues. Ordered logistic regression models are employed to examine the association between physical frailty and life satisfaction. RESULTS: The prevalence of frailty was higher in older women than men (32.2% vs. 27.5%). Nearly 30.4% of men and 33.8% of women reported having LLS. However, after adjusting for the selected confounders, women were less likely (adjusted odds ratio [aOR]: 0.92; CI: 0.87-0.97) to report LLS compared to men. The physically frail older adults were more likely (aOR: 1.40; CI: 1.27-1.55) to report LLS relative to their physically stronger counterparts. Moreover, we found that frail older men had higher odds of reporting LLS than non-frail older men (aOR: 1.25; CI: 1.09-1.43). Also, non-frail older women had lower odds of reporting LLS than non-frail older men (aOR: 0.80; CI: 0.67-0.95). CONCLUSIONS: Findings of our study suggest that policies and programs to address later life well-being need to consider gender differences. Doing so would not only help identify older adults most at risk of LLS, but gender differentiated policies would help streamline health expenditures and costs typically relegated to assist all older adults without proper focus on the uniqueness of their social location.

Association between food insecurity and quality of life among older adults (60+) in six low and middle-income countries.

Food insecurity is a key social determinant of health and nutrition. However, very few studies have examined the association of food insecurity and quality of life outcomes among older adults in low and middle-income settings. In this study, we examine the association of food insecurity with self-rated poor quality of life, low life satisfaction, and WHO quality of life (WHOQol). Nationally representative data from WHO's Study on global AGEing and adult health (SAGE) consisting of 20,026 older adults were analyzed. The association of food insecurity with self-rated poor quality of life and low life satisfaction was assessed using bivariate and multivariate logistic regression analysis. Multivariate linear regression models examine the association between food insecurity and WHOQol score. Pooled data analysis of six countries showed older adults with severe food insecurity were two times more likely to report poor quality of life (OR = 2.49, CI 2.10, 2.96; p < 0.001) and low life satisfaction (OR = 2.36, CI 1.94, 2.87; p < 0.001), respectively. Similarly, older adults with severe food insecurity had 3.60 (CI-4.25, -2.95; p < 0.001) points lower WHO-QoL score than those who are food secure. These results show that the association of food insecurity is statistically significant with all three outcomes of quality of life in all six countries adjusting for sociodemographic and health measures. Public health and social security interventions are important to prevent food insecurity to promote overall wellbeing of the growing older population in low and middle-income countries.

Association of long and short interpregnancy intervals with maternal outcomes.

Background: Interpregnancy interval (IPI) is spacing between live birth and beginning a new pregnancy. Both long and short IPIs have been associated with adverse maternal outcomes. There is paucity in the Indian literature regarding the impact of IPI on maternal outcomes. Materials and Methodology: The cross-sectional study was conducted in the Department of Obstetrics and Gynecology, King George's Medical University, Lucknow, from July 2019 to June 2020. Women with previous abortions, previous stillbirth, nulliparity, or multiple pregnancies were excluded. A pre-structured pro forma was used for demographic details. IPI was categorized as <6 months, 6 to <24 months, 24 to <60 months, and 60 months. Maternal outcomes were studied, and odds ratios were calculated. Results: There were 6984 deliveries in the period. A total of 4812 women were enrolled after following the inclusion and exclusion criteria. Of 4812 women, 142 (2.9%) had IPI <6 months, 3336/4812 women (69.3%) had IPI 6 to <24 months, 1144/4812 women (23.7%) had IPI 24 to <60 months, and 3.9% women (190/4812) had IPI ≥60 months. High risk of fetal malposition (OR 3.84), fetal growth restriction (OR 2.06), and hypertension (OR 1.86) were seen in women with short IPI <6 months. Women with longer IPI (≥ 60 months) had higher chances of preterm labor (OR 3.82), oligoamnios (OR 2.54), gestational diabetes (OR 2.19), and anemia (OR 1.45). Conclusion: Three-fourths of women had IPI less than 24 months recommended as minimum interval by WHO. Efforts are needed to increase awareness and availability of contraceptive choices for postpartum women to ensure adequate spacing.

Preparation, characterization and evaluation of the zinc titanate and silver nitrate incorporated wipes for topical chemical and biological decontamination.

Chemical and biological warfare agents have detrimental effects on biological systems. These agents are rapidly absorbed through skin and hence warrant immediate decontamination. Zinc titanate (ZnTiO3), is a well-proven moiety used for neutralizing chemical warfare agents (CWA) and silver is widely used as an antibacterial agent. Spacer fabric sheet, due to its ability to hold large amount of agents, was hydrothermally treated with silver nitrate (AgNO3) and incorporated with nano ZnTiO3 to prepare decontamination (deconwipes). Prepared deconwipe was characterized using X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). Uniform deposition of nano ZnTiO3 and AgNO3 in the wipe was demonstrated by SEM and XRD. In-vivo dermal decontamination efficacy of the prepared deconwipe was evaluated against nerve agent simulant (diethylchlorophosphate; DCP) and sulfur mustard simulant (2­chloroethyl ethyl sulfide; CEES) on rat model using SEM, Flow Cytometry, Comet Acetylcholinesterase (AChE) inhibition assay and Organ Histopathology. In-vitro antibacterial and antifungal efficacy of the prepared deconwipe was evaluated using growth inhibitory efficacy techniques followed by SEM analysis. SEM and histopathology at dermal level revealed the decontamination efficacy of the prepared deconwipe. Nearly 90% decrease in AChE inhibition was observed in decontaminated rat in place of rate model as compared to the DCP contaminated rats. No significant attenuation was observed in DCP and CEES-induced cell cycle distribution and DNA damage analysis in decontaminated group. Furthermore, >95% inhibition of bacterial and fungal growth, proved its antibacterial and antifungal activity respectively. Thus, prepared deconwipes exhibit promising skin decontamination property against Chemical and biological contaminants.