Diagnostic value of repeated comprehensive investigation with CT urography and cystoscopy for recurrent macroscopic haematuria.

Objectives: To perform a descriptive analysis of a series of patients with recurrent macroscopic haematuria after a primary standard evaluation including computed tomography urography (CTU) and cystoscopy negative for urinary bladder cancer (UBC) and upper tract urothelial cancer (UTUC) and to identify potential factors associated with occurrence of recurrent macroscopic haematuria. Methods: All patients older than 50 years who underwent urological investigation for macroscopic haematuria with both cystoscopy and CTU 2015-2017 were retrospectively reviewed. A descriptive analysis of the primary and later investigations for recurrent macroscopic haematuria was performed. To investigate the association between explanatory variables and the occurrence of recurrent macroscopic haematuria, a Poisson regression analysis was performed. Results: A total of 1395 eligible individuals with primary standard investigation negative for UBC and UTUC were included. During a median follow-up of 6.2 (IQR 5.3-7) years, 248 (18%) patients had recurrent macroscopic haematuria, of whom six patients were diagnosed with UBC, two with prostate cancer, one with renal cell carcinoma and one had a suspected UTUC at the repeated investigation. Within 3 years, 148 patients (11%) experienced recurrent macroscopic haematuria, of whom two patients were diagnosed with low-grade UBC (TaG1-2), one with T2G3 UBC and one with low-risk prostate cancer. The presence of an indwelling catheter, use of antithrombotic medication, pathological findings at CTU or cystoscopy or history of pelvic radiotherapy were all statistically significant independent predictors for increased risk for recurrent macroscopic haematuria. Conclusion: In the case of recurrent macroscopic haematuria within 3 years of primary standard evaluation for urinary tract cancer, there was a low risk of later urological malignancies in patients initially negative for UBC and UTUC. Therefore, waiting 3 years before conducting another complete investigation in cases of recurrent macroscopic haematuria might be appropriate.

A Rare Case of Autoimmune Enteropathy Associated with Autoimmune Hepatitis.

A 74-year-old woman was admitted for weight loss, abdominal pain and diarrhea for a year. Blood tests showed elevated transaminases, cholestasis and hyperbilirubinemia. Capsule endoscopy revealed extensively scattered lymphangiectasias, shortened villi and erosions in the jejunum and ileum. The histological examination of the small bowel mucosa biopsies evidenced severe mucosal atrophy and crypt hyperplasia, without significant intraepithelial lymphocytosis. The clinical picture, lack of response to a gluten-free diet and endoscopic and histopathologic findings were compatible with autoimmune enteropathy. Simultaneously, autoimmune hepatitis was also diagnosed. The patient showed significant improvement after starting treatment with prednisolone and azathioprine. To our knowledge, this is the first case of autoimmune enteropathy diagnosed simultaneously with autoimmune hepatitis.

Pancreatic Cancer and Primary Sjögren's Syndrome: A Case Report.

Primary Sjögren syndrome (SS) is a chronic inflammatory systemic autoimmune disease with a high risk of malignancy development, namely, lymphoproliferative neoplasms. Few studies also reported a high risk of solid cancers; however, the coexistence of primary SS and pancreatic cancer has been rarely described. In this paper, we aim to describe a case of a 59-year-old woman who was an active smoker with sicca symptoms and symmetrical polyarthritis and was diagnosed with primary SS two years before the development of metastatic pancreatic adenocarcinoma. Despite institution of chemotherapy, the patient succumbed to the malignancy. Besides that, we explore the link between primary SS and solid cancers including the main predictors of malignancy and the role of primary SS as a paraneoplastic syndrome. Patients with primary SS should be closely monitored for malignancy, not only for hematological cancer, but also for solid tumors. Further research is necessary to understand which are the predictors of cancer proliferation in primary SS patients.

Os desafios do trabalho de grupo no núcleo de prevenção à violência na UBS Vila Maggi / The challenges of group work at the violence prevention core in UBS Vila Maggi / Los desafíos del trabajo grupal en el centro de prevención de violencia UBS Vila Maggi

RESUMO A violência é um fenômeno complexo e multifatorial, que se configura como problema social com forte impacto na saúde. No território de abrangência da UBS Vila Maggi, acolhemos cotidianamente diversos tipos de violências relacionados ao contexto familiar. Entendendo que todos os grupos populacionais são vulneráveis à violência, e que a violência guarda relações profundas com a estrutura social, econômica e política, compreende-se que a esta se dá de forma mais impactante em regiões socioeconômicas mais vulneráveis e com condições inadequadas de habitabilidade.

ABSTRACT Violence is a multifatorial and complex phenomenon that configurates as a social problem with heavy impact in our health. In the territory of the UBS Vila Maggi, we routinely recieve several types of family related violence. In understanding that all populational groups are subjected to violence and that violence itself holds deeps relations with political, economic and social structure, one can understands that it will impact more heavily in vulnerable regions with poor housing and poor social-economic conditions.

RESUMEN La violencia es un fenómeno multifatorial y complejo que se configura como un problema social con gran impacto en nuestra salud. En el territorio de la UBS Vila Maggi, habitualmente recibimos varios tipos de violencia familiar. Al comprender que todos los grupos poblacionales están sujetos a la violencia y que la violencia en sí misma mantiene profundas relaciones con la estructura política, económica y social, uno puede entender que tendrá un mayor impacto en las regiones vulnerables con viviendas y condiciones socioeconómicas pobres.

Acute Ischemic Stroke Outcome and Preceding Anticoagulation: Direct Oral Anticoagulants Versus Vitamin K Antagonists.

BACKGROUND AND PURPOSE: Acute ischemic stroke (AIS) severity and clinical course are less known in direct oral anticoagulants (DOAC) users. We aimed to explore the outcome of AIS in patients pretreated with vitamin-K-antagonists (VKA) and DOAC. METHODS: A retrospective study was performed. Patients pretreated with oral anticoagulants (OAC) for nonvalvular atrial fibrillation admitted for AIS in a stroke unit between 2016-01-01 and 2018-08-31 were included. The primary endpoint was mortality during the hospital stay, and secondary endpoints were neurologic improvement at stroke unit discharge and good functional outcome 90 days after AIS. RESULTS: A total of 156 patients were included (83 on VKA and 73 on DOAC). Stroke severity (defined by NIHSS on admission) was comparable in both groups (AVK 13.0 [4.0-20.0] versus DOAC 11.0 [4.0-17.0], P = .435). Infratherapeutic levels and/or inappropriate low dose of OAC was also similar between groups (P = .152) and was not associated with stroke severity (P = .631) or mortality (P = .788). VKA (OR 12.616, P = .035, 95%CI 1.19-133.64) and PH2 hemorrhagic transformation (OR 7.516, P = .024, 95%CI 1.31-43.20) were associated with higher mortality in multivariate analysis. Higher stroke severity (OR .101, P < .001, 95%CI .037-.279) and VKA usage (OR .212, P = .003, 95%CI .08-.58) were associated with worse functional outcome at 3 months. Reperfusion therapy was significantly associated with neurologic improvement during stroke unit stay (OR 3.969, P = .009, 95%CI 1.42-11.11) but not with the functional outcome (P = .063). CONCLUSIONS: Nonvalvular atrial fibrillation patients pretreated with DOAC admitted for AIS had a better outcome when compared to VKA, although stroke severity was similar between groups.

Systolic function recovery in Heart Failure: Frequency, prognostic impact and predictors.

BACKGROUND: Systolic function recovery in patients with Heart failure (HF) with reduced ejection fraction (EF) is well recognized but not completely understood. We aimed to characterize HF patients with systolic function recovery, its prognostic impact and predictors. METHODS: We analysed patients followed in a HF clinic (2006-2015) with 2 echocardiograms performed. Partial recovery: EF recovery without attaining EF ≥ 50%; total recovery: patients reached EF ≥ 50%. Median follow-up from first echocardiogram: 69 months. Multivariate logistic regression models to determine recovery predictors. RESULTS: We analysed 304 patients with at least mild left ventricular dysfunction. During a median 34 months between echocardiogram re-evaluation 150 (49.3%) patients showed no EF recovery; 55 (18.1%) had partial recovery and 99 (32.6%) totally recovered. Mean patients age: 66; 71.1% men, high comorbidity burden; ischemic HF: 35.5%. Non-recovered patients were mostly men (80.7% vs 61.8% in partially; 61.6% in fully-recovered) with ischemic HF (46.0% vs 32.5% in partially; 21.2% in fully-recovered). Comorbidity burden, NYHA class and therapy were similar. During follow-up, 156 patients (46.7%) died. Patients with total recovery had a multivariate-adjusted 54% lower risk of dying when compared to non-recovered. Partially-recovered patients showed a non-significant adjusted 8% mortality reduction. Independent predictors of systolic function recovery were female gender(OR: 2.17, 95% CI 1.11-4.35), non-ischemic aetiology (OR: 2.78, 95% CI 1.35-5.56), and end diastolic left ventricular diameter < 60 mm (OR: 3.12, 95% CI 1.56-6.25). CONCLUSIONS: HF-recovered patients were mainly women with non-ischemic HF and smaller left ventricles. These patients had significantly better prognosis than those with persistently reduced EF.

Cardiac Angiosarcoma: From Cardiac Tamponade to Ischaemic Stroke - A Diagnostic Challenge.

Cardiac angiosarcoma (CA) is the most common primary malignant heart tumour. Its atypical symptoms and rapidly progressive nature contribute to delayed diagnosis and poor outcome. We report the case of a 52-year-old woman admitted with a large pericardial effusion. An extensive study of the aetiology of the pericardial effusion was inconclusive. Two months later the patient returned with ischaemic stroke. An echocardiogram revealed a probable right atrium contained rupture. The patient was submitted to surgical correction but died 9 days later. Histology revealed an angiosarcoma. This case exemplifies the atypical presentation of CA and highlights the importance of a multimodal diagnostic work-up in patients with idiopathic pericardial effusion. LEARNING POINTS: Cardiac angiosarcoma is often overlooked as an initial diagnosis because of its rarity and atypical symptoms, which, in association with its aggressiveness, contribute to delayed diagnosis and fatal outcome.Pericardial biopsy is an important technique that may help to disclose the aetiology of pericardial effusion and should be considered for the confirmation of malignant pericardial disease.Patients presenting with pericardial effusion with cardiac tamponade with an unclear cause after diagnostic work-up should be followed closely.

Whipple's Disease as the First Manifestation of Chronic Lymphocytic Leukaemia.

Whipple's disease is a rare multisystemic infectious disease that can mimic lymphoproliferative disorders and must be considered in the differential diagnosis of febrile syndromes. The authors describe the case of a 55-year-old man who presented to the Emergency Department with dyspnoea and abdominal pain. He had a 2-month history of fever, night sweats, asthenia and unintentional weight loss. Upon clinical examination he had bilateral inguinal lymphadenopathy. Blood tests showed iron-deficit anaemia and high C-reactive protein. Abdominal ultrasound showed mesenteric and iliac adenopathies and hepatosplenomegaly. The patient was admitted to the Internal Medicine department for additional testing. Flow cytometry analysis of peripheral blood showed CD5-positive monoclonal B-cell expansion. Excisional biopsy of a retroperitoneal adenopathy guided by computed tomography showed periodic acid-Schiff-positive bacilli inside the macrophages, further identified as Tropheryma whipplei through polymerase chain reaction. Bone marrow biopsy showed a scarce positive CD5 lymphoid population and haematopoietic alterations related to infection. The patient started treatment for T. whipplei with complete symptom resolution. This is the first case describing the simultaneous diagnosis of Whipple's disease and chronic lymphocytic leukaemia in a patient with constitutional symptoms, fever and lymphadenopathies. LEARNING POINTS: Whipple's disease can mimic lymphoproliferative disorders and should be considered in the differential diagnosis of lymphadenopathy and fever, even in the absence of gastrointestinal symptoms.Most patients with chronic lymphocytic leukaemia are asymptomatic, but a minority have B symptoms and increased risk of infections.An accurate clinical history and differential diagnosis are fundamental; if the authors had not had a high level of suspicion, this patient could have been diagnosed with just chronic lymphocytic leukaemia and may have died if Whipple's disease had been left untreated.

Cervical Lymphadenopathy in a Nonagenarian Woman: What to Think?

Tuberculosis remains a worldwide public health problem. Cervical tuberculous lymphadenitis (TBL) or scrofula is the most common form of extrapulmonary tuberculosis, affecting the cervical lymph nodes. We report the case of a 93-year-old woman presenting with cervical adenopathies with 3 months duration. Fine needle aspiration (FNA) biopsy yielded a noncaseous granulomatous process, but was negative for Mycobacterium tuberculosis (MT). As the adenopathies had grown, an excisional biopsy was performed. An extensive study of infectious aetiologies was performed, including for MT, with a negative outcome. Owing to the persistence of cervical lymphadenitis with caseous granulomas, a diagnosis of TBL was strongly suspected and presumptive treatment was initiated. Afterwards, diagnostic confirmation was obtained by isolation of MT in the lymph node culture. The patient presented a favourable clinical outcome. This case highlights that a high index of suspicion is essential for the diagnosis of TBL, especially in the elderly, and emphasizes the importance of pursuing diagnostic confirmation, in which FNA and excisional biopsy plays a key role. LEARNING POINTS: The diagnosis of tuberculous lymphadenitis should be considered in all patients presenting with cervical adenopathies, especially in endemic areas, irrespective of the patient's age.A high index of suspicion is essential for the diagnosis due to the wide range of conditions that can mimic the disease.Fine needle aspiration biopsy is appropriate as an initial diagnostic approach, with excisional biopsy recommended when the former is not diagnostic.

Is Low-Dose Radiation Exposure a Risk Factor for Atherosclerotic Disease?

Nontargeted late effects of radiation include an increased risk of cardiovascular disease, although this is still debatable in the context of low-dose radiation. Tinea capitis patients treated in childhood with X rays to induce scalp epilation received a low dose of radiation to their carotids. To better clarify this issue, we evaluated carotid atherosclerosis in a cohort of such patients treated in 1950-1963 in Portugal. A group of 454 individuals randomly chosen from previously observed Portuguese tinea capitis patients and a control group mainly composed of their spouses (n = 280) were enrolled. Cardiovascular risk factors such as waist circumference, body mass index, blood pressure and tobacco consumption, as well as biochemical measurements were obtained. Ultrasound imaging of carotid arteries for intima media thickness and stenosis evaluation were performed according to a standardized protocol. In comparison to the control group, the irradiated cohort members were significantly older, more frequently never smokers, hypertensive, and presented higher glycated hemoglobin and alkaline phosphatase levels. In addition, the irradiated cohort showed a higher frequency of carotid stenosis ≥30% than the nonirradiated group (13.9% vs. 10.7%), although this was not significant ( P = 0.20). Stenosis was ≥50% in 2.9% of the irradiated group and 0.4% of the nonirradiated group ( P = 0.02). Likewise, the frequency of intima media thickness ≥1 mm was significantly higher in the irradiated group (16.8% vs. 10.7%; P = 0.02). Multivariate analysis, including other cardiovascular risk factors, showed that exposure to low-dose radiation increased the risk of carotid stenosis by ≥50% [odds ratio (OR) = 8.85; P = 0.04] and intima media thickness by ≥1 mm (OR = 1.82; P = 0.02). These findings confirm that low-dose exposure is a risk factor of carotid atherosclerotic disease.

Shear Bond Strength and Adhesive Remnant of Three Protocols used for Bonding Orthodontic Brackets

Objective: To test the shear bond strength and the amount of adhesive remnant on the enamel after debonding of a conventional orthodontic composite system, a flowable composite resin, and a self-adhesive resin cement. Material and Methods: Thirty extracted bovine incisors were allocated in three groups, according to the type of adhesive: Group XT (Transbond XT), Group FL (Flow Z350), and Group RX (RelyX U100). All groups had etching with phosphoric acid. Groups XT and FL received primer before adhesive. Stainless steel metal brackets were bonded using the respective adhesive. Teeth were submitted to shear bond strength (SBS) test, followed by measurement of adhesive remnant. Intergroup comparison of SBS values were performed by one-way Anova and Tukey post-hoc test. Kruskal-Wallis test and the Mann-Whitney U-test were used to compare adhesive remnant. Results: Transbond XT presented higher bond strength than RelyX U100 and Flow Z350; all adhesives exhibited bond failure within the adhesive. All groups showed bond failure occurring within the adhesive. Transbond XT and RelyX U100 left significantly more adhesive remnant on the tooth surface than Flow Z350. Conclusion: All three adhesive systems had bond strength above the minimum for clinical routine use. As regards to bond strength, Transbond XT performed better than the resin cement and the flowable resin. Bond failure occurred within the adhesive in all groups.

A proporção áurea como complemento na determinação da dimensão vertical / The golden proportion as a method for the determination of complementary vertical dimension

O objetivo deste estudo foi avaliar se as medidas faciais utilizadas em métodos tradicionais para determinação da Dimensão Vertical de Oclusão estão em Proporção Áurea (1: 1,618) e, por conseguinte, se podem ser utilizadas como método complementar para determinação desta dimensão. Foram selecionados aleatoriamente pacientes entre 20 e 30 anos, da clínica de Odontologia da Universidade Estadual da Paraíba. A amostra foi composta por 30 indivíduos, sendo 15 do gênero masculino e 15 do gênero feminino. Através da análise de fotografias frontais destes indivíduos, e traçados que trespassam pontos cefalométricos, foi possível elucidar novas abordagens nos tratamentos de reabilitação oral. Em relação ao grau da DTM dos pacientes pesquisados, 63,3% (n = 19) apresentavam algum grau de DTM, sendo que 50% (n = 15) apresentavam DTM leve, 10% (n = 3) apresentavam DTM moderada e apenas 3,3% apresentavam DTM severa. O restante, 36,7% (n = 11), não apresentava sinais ou sintomas de disfunções de ATM. Podemos afirmar, através deste estudo, que em pacientes sem DTM tanto os métodos de mensuração facial como os métodos fisiológicos, como o de Litle modificado por Tamaki, são eficientes na determinação da Dimensão Vertical. Porém, em pacientes com disfunções, os métodos se mostraram imprecisos.

The purpose of this study was to evaluate whether the facial measures used in traditional methods of determination of the Occlusion Vertical Dimension are in Divine Proportion (1:1,618) and, subsequently, whether this Proportion can be used as a complementary method for determination of the dimension. For that, 20 to 30 year-old patients were selected at random from Odontology Clinics of the Paraíba State University. The sample was composed by 30 individuals, 15 of male gender and 15 female gender. Through the analysis of frontal photographs of these individuals, and the designs that trespass cephalometric points, it was possível to elucidate new approches on treatements of oral reabilitation. With regard to the degree of the Temple-mandible Disfunction, 63,3% (n=19) of the patients showed some degree of TMD, of whom 50% (n=15) showed mild TMD, 10% (n = 3) showed moderate TMD and only 3.3% showed severe TMD. The rest, 36.7% (n=11), did not show any signs or symptoms of TMA disfunctions. We can state that in patients without TMD, both the methods of facial measures and physiologic methods, such as Litle's Method modified by Tamaki, are efficient in the determination of the Vertical Dimension. However, in patients with TMD the physiologic methods were imprecise.

Obstetricians' knowledge of periodontal disease as a potential risk factor for preterm delivery and low birth weight.

There is little information about the knowledge and attitudes of physicians regarding oral care. This study aimed to assess the knowledge and attitudes of obstetricians about the relationship between periodontal disease and preterm/low birth weight. A questionnaire was emailed to members of the Brazilian Federation of Gynecology and Obstetrics (FEBRASGO). The questionnaire elicited both personal information and knowledge and attitudes regarding the relationship between periodontal diseases and preterm labor. A total of 875 obstetricians responded to the questionnaire. The majority of respondents were female (54.1%), resided in the Southeast (45.6%), worked in both the public and private sectors (61.4%), and had over 15 years of experience in obstetrics (48.9%). A large proportion of obstetricians (93.4%) stated that bacteria were associated with periodontal disease, and 94% reported that periodontitis was a condition more severe than gingivitis. In total, over 80% of participating obstetricians reported smoking, preeclampsia, bacterial vaginosis and periodontal disease as risk factors or possible risk factors for preterm birth or low birth weight. A correlation between the experience of the obstetricians and referral of their patients for dental examinations (p < 0.001) was observed. Also, obstetricians who had had their own dental visits more recently were more likely to recommend the same for their patients (p < 0.001). It is concluded that, although obstetricians were aware of the association between gingival inflammation and adverse obstetric outcomes, the attitudes of these professionals were not in agreement with their apparent knowledge regarding periodontal diseases and their possible repercussions.

Obstetricians' knowledge of periodontal disease as a potential risk factor for preterm delivery and low birth weight

There is little information about the knowledge and attitudes of physicians regarding oral care. This study aimed to assess the knowledge and attitudes of obstetricians about the relationship between periodontal disease and preterm/low birth weight. A questionnaire was emailed to members of the Brazilian Federation of Gynecology and Obstetrics (FEBRASGO). The questionnaire elicited both personal information and knowledge and attitudes regarding the relationship between periodontal diseases and preterm labor. A total of 875 obstetricians responded to the questionnaire. The majority of respondents were female (54.1 percent), resided in the Southeast (45.6 percent), worked in both the public and private sectors (61.4 percent), and had over 15 years of experience in obstetrics (48.9 percent). A large proportion of obstetricians (93.4 percent) stated that bacteria were associated with periodontal disease, and 94 percent reported that periodontitis was a condition more severe than gingivitis. In total, over 80 percent of participating obstetricians reported smoking, preeclampsia, bacterial vaginosis and periodontal disease as risk factors or possible risk factors for preterm birth or low birth weight. A correlation between the experience of the obstetricians and referral of their patients for dental examinations (p < 0.001) was observed. Also, obstetricians who had had their own dental visits more recently were more likely to recommend the same for their patients (p < 0.001). It is concluded that, although obstetricians were aware of the association between gingival inflammation and adverse obstetric outcomes, the attitudes of these professionals were not in agreement with their apparent knowledge regarding periodontal diseases and their possible repercussions.

Custo, efetividade e custo-efetividade do tratamento periodontal em gestantes / Cost, effectiveness, cost-effectiveness of systematic periodontal treatment performed on pregnant women

Análises econômicas em saúde bucal são escassas na literatura e, portanto, muitasdas práticas, especialmente aquelas propostas e realizadas nos sistemas públicos de saúde em diferentes países, são realizadas sem o conhecimento de seus aspectos econômicos. Na maioria dos países, os recursos destinados à saúde são limitados e, portanto, carecem de análises econômicas para que se tenha base científica para a proposição e implementação de diretrizes de atenção à saúde.O presente estudo trata de uma análise econômica em saúde bucal que teve porobjetivo avaliar o custo, a efetividade e o custo-efetividade do tratamento periodontal sistemático, comparando-o com o tratamento convencional realizado em gestantes no Hospital Materno Infantil Presidente Vargas, na perspectiva do Sistema Único deSaúde, partindo de dados já coletados nos prontuários de 213 pacientes. O custo do tratamento periodontal sistemático e o ofertado pelo HMIPV foram estimados a partir do somatório dos custos de todas as consultas de exames periodontais, instruçõesde higiene bucal. raspagens alisamentos e polimentos supragengivais e raspagem e alisamento radiculares subgengivais por gestante. O tratamento periodontal sistemático custou R$ 442,80, levando em média 8,23 consultas por gestante, e o tempo médio gasto para a realização do tratamento foi de 6 horas e 35 minutos. O tratamento periodontal ofertado pelo HMIPV teve um custo médio de R$ 144,05 e uma média de2,96 consulta por paciente; o tempo total médio para a realização desse tratamento foi de 2 horas e 15 minutos. A razão de custo-efetividade para se controlar a doença periodontal por gestante mediante o tratamento periodontal sistemático é de R$ 6,91e de R$ 9,50 pelo tratamento ofertado pelo HMIPV. Os resultados do presenteestudo permitem concluir que o tratamento periodontal sistemático é custo-efetivo em reduzir processo inflamatório periodontal, não sendo influenciado diretamente por tabagismo, renda e escolaridade.

Economic analyses of oral health are scarce in the literature and therefore many of the practices, especially those proposed and implemented in public health systems in different countries, are performed without the knowledge of its economic aspects. In most countries, resources for health are limited and therefore lack economic analyses in order to have a scientific basis for proposing and implementing policiesfor health care. This study deals with an economic analysis of oral health that aims to assess the cost, effectiveness and cost-effectiveness of systematic periodontal treatment, compared with conventional treatment performed on pregnant women in the Maternal and Child Hospital Presidente Vargas, the prospect of health system, based on data already collected from medical records of 213 patients. The cost ofperiodontal treatment were estimated from the sum of the costs of all queriesincluding periodontal examinations, oral hygiene instructions, supragingival andsubgingival scaling per pregnant women. The systematic periodontal treatment cost was R$ 442.80, taking an average of 8.23 consultations per pregnant woman, and the average time taken for completion of treatment was 6 hours and 35 minutes. Periodontal treatment offered by HMIPV had an average cost of R$ 144.05 and anaverage of 2.96 consultations per patient, the average total time to perform this treatment was 2 hours and 15 minutes. The cost-effectiveness ratio to control periodontal disease in pregnant women through systematic periodontal treatment is R$ 6.91 and R$ 9.50 for the treatment offered by HMIPV. The results of this studyallow us to conclude that the systematic periodontal treatment is cost-effective inreducing periodontal inflammation and is not directly influenced by smoking, income and education.

Resistência acaricida em larvas de Rhipicephalus sanguineus (Acari: Ixodidae) de Goiânia-GO, Brasil / Acaricide resistence in Rhipicephalus sanguineus (Acari: ixodidae) larvae from Goiânia-GO, Brazil

Fêmeas ingurgitadas de Rhipicephalus sanguineus foram colhidas em cães provenientes de diferentes regiões de Goiânia e incubadas para a produção de larvas. Usando-se um teste de imersão, larvas de 7 a 21 dias de idade foram testadas ante os seguintes acaricidas e concentrações (em ppm): amitraz (250, 125, 62,5 e 31,2), coumafós (500, 250, 125 e 62,5), cipermetrina (150, 75, 37,5 e 18,7), deltametrina (25, 12,5, 6,2 e 3,1) e fipronil (312, 156, 78, 39 e 19,5). Cálculos das DL50 e DL99 foram feitos por meio do programa de análise do probito. Cepas com DL99 acima daquelas recomendadas pelo fabricante ou pela literatura foram consideradas como resistentes. Nenhuma das 15 amostras testadas ante o amitraz teve a DL99 superior à concentração recomendada. Ante a deltametrina, a cipermetrina e o coumafós, nove (75por cento), sete (78por cento) e sete (78por cento) amostras, respectivamente, tiveram DL99 superior à recomendada. As DL50 variaram de 4 a 16 ppm, 0,3 a 3,2 ppm, 1 a 20 ppm e 17 a 75 ppm em relação a amitraz, deltametrina, cipermetrina e coumafós, respectivamente. Houve mortalidade de 100por cento das larvas testadas em todas as concentrações do fipronil. Estes resultados demonstram que a maioria das cepas de R. sanguineus de Goiânia apresentaram resistência à cipermetrina, à deltametrina e ao coumafós. Não se verificou resistência ao amitraz na população de R. sanguineus estudada.

Tratamento endodôntico em dentes com rizogênese incompleta: técnica empregada pela disciplina de endodontia da PUC-PR / Endodotic treatment on teeth with incompletely formed roots technique used by the endodontics course at PUC-PR

Os autores relatam a sequência técnica do tratamento endodôntico em dentes com rizogênese incompleta, adotada pela disciplina de endodontia da PUC-PR. Focalizam em especial a técnica para dentes com rizogênese incompleta com o tecido necrosado - apexificação. Enfatizam ainda os vários tipos de tratamento quanto ao desenvolvimento radicular, observando a necessidade de se dar mais atenção aos exames radiográficos e clínico, visando à constatação do estágio de desenvolvimento radicular em Classe III de Patterson, onde nem sempre a imagem radiográfica pela face vestibular do forame apical correspondente à face proximal, quanto ao diâmetro deste