MCH-PAN: gastrointestinal polyp detection model integrating multi-scale feature information.

The rise of object detection models has brought new breakthroughs to the development of clinical decision support systems. However, in the field of gastrointestinal polyp detection, there are still challenges such as uncertainty in polyp identification and inadequate coping with polyp scale variations. To address these challenges, this paper proposes a novel gastrointestinal polyp object detection model. The model can automatically identify polyp regions in gastrointestinal images and accurately label them. In terms of design, the model integrates multi-channel information to enhance the ability and robustness of channel feature expression, thus better coping with the complexity of polyp structures. At the same time, a hierarchical structure is constructed in the model to enhance the model's adaptability to multi-scale targets, effectively addressing the problem of large-scale variations in polyps. Furthermore, a channel attention mechanism is designed in the model to improve the accuracy of target positioning and reduce uncertainty in diagnosis. By integrating these strategies, the proposed gastrointestinal polyp object detection model can achieve accurate polyp detection, providing clinicians with reliable and valuable references. Experimental results show that the model exhibits superior performance in gastrointestinal polyp detection, which helps improve the diagnostic level of digestive system diseases and provides useful references for related research fields.

A predictive model for classifying college students' academic performance based on visual-spatial skills.

As the application of visual-spatial skills in academic disciplines, vocational fields and daily life is becoming more and more prominent, it is of great theoretical and practical significance how to make use of big data and artificial intelligence technology to conduct research on the relationship between visual-spatial skills and students' grades. This paper explores and analyses from the perspective of artificial intelligence, combining students' visual-spatial skills and students' specific attribute characteristics to construct an expert system, which defines the prediction of academic performance as a classification problem corresponding to the five categories of excellent, good, moderate, passing, and weak, respectively, and based on which a deep neural network-based classification prediction model for students' performance is designed. The experimental results show that visual-spatial skills plays an important role in the professional learning of science and engineering students, while the classification model designed in this paper has high accuracy in the grade prediction process. This paper not only helps to fill the gaps in the current research field, but is also expected to provide scientific basis for educational practice and promote the development of the education field in a more intelligent and personalized direction.

A semantic feature enhanced YOLOv5-based network for polyp detection from colonoscopy images.

Colorectal cancer (CRC) is a common digestive system tumor with high morbidity and mortality worldwide. At present, the use of computer-assisted colonoscopy technology to detect polyps is relatively mature, but it still faces some challenges, such as missed or false detection of polyps. Therefore, how to improve the detection rate of polyps more accurately is the key to colonoscopy. To solve this problem, this paper proposes an improved YOLOv5-based cancer polyp detection method for colorectal cancer. The method is designed with a new structure called P-C3 incorporated into the backbone and neck network of the model to enhance the expression of features. In addition, a contextual feature augmentation module was introduced to the bottom of the backbone network to increase the receptive field for multi-scale feature information and to focus on polyp features by coordinate attention mechanism. The experimental results show that compared with some traditional target detection algorithms, the model proposed in this paper has significant advantages for the detection accuracy of polyp, especially in the recall rate, which largely solves the problem of missed detection of polyps. This study will contribute to improve the polyp/adenoma detection rate of endoscopists in the process of colonoscopy, and also has important significance for the development of clinical work.

G-YOLO: A YOLOv7-based target detection algorithm for lightweight hazardous chemical vehicles.

Hazardous chemical vehicles are specialized vehicles used for transporting flammable gases, medical waste, and liquid chemicals, among other dangerous chemical substances. During their transportation, there are risks of fire, explosion, and leakage of hazardous materials, posing serious threats to human safety and the environment. To mitigate these possible hazards and decrease their probability, this study proposes a lightweight object detection method for hazardous chemical vehicles based on the YOLOv7-tiny model.The method first introduces a lightweight feature extraction structure, E-GhostV2 network, into the trunk and neck of the model to achieve effective feature extraction while reducing the burden of the model. Additionally, the PConv is used in the model's backbone to effectively reduce redundant computations and memory access, thereby enhancing efficiency and feature extraction capabilities. Furthermore, to address the problem of performance degradation caused by overemphasizing high-quality samples, the model adopts the WIoU loss function, which balances the training effect of high-quality and low-quality samples, enhancing the model's robustness and generalization performance. Experimental results demonstrate that the improved model achieves satisfactory detection accuracy while reducing the number of model parameters, providing robust support for theoretical research and practical applications in the field of hazardous chemical vehicle object detection.

Colorectal image analysis for polyp diagnosis.

Colorectal polyp is an important early manifestation of colorectal cancer, which is significant for the prevention of colorectal cancer. Despite timely detection and manual intervention of colorectal polyps can reduce their chances of becoming cancerous, most existing methods ignore the uncertainties and location problems of polyps, causing a degradation in detection performance. To address these problems, in this paper, we propose a novel colorectal image analysis method for polyp diagnosis via PAM-Net. Specifically, a parallel attention module is designed to enhance the analysis of colorectal polyp images for improving the certainties of polyps. In addition, our method introduces the GWD loss to enhance the accuracy of polyp diagnosis from the perspective of polyp location. Extensive experimental results demonstrate the effectiveness of the proposed method compared with the SOTA baselines. This study enhances the performance of polyp detection accuracy and contributes to polyp detection in clinical medicine.

Registration-free 3D super-resolution generative deep-learning network for fluorescence microscopy imaging.

Volumetric fluorescence microscopy has a great demand for high-resolution (HR) imaging and comes at the cost of sophisticated imaging solutions. Image super-resolution (SR) methods offer an effective way to recover HR images from low-resolution (LR) images. Nevertheless, these methods require pixel-level registered LR and HR images, posing a challenge in accurate image registration. To address these issues, we propose a novel registration-free image SR method. Our method conducts SR training and prediction directly on unregistered LR and HR volume neuronal images. The network is built on the CycleGAN framework and the 3D UNet based on attention mechanism. We evaluated our method on LR (5×/0.16-NA) and HR (20×/1.0-NA) fluorescence volume neuronal images collected by light-sheet microscopy. Compared to other super-resolution methods, our approach achieved the best reconstruction results. Our method shows promise for wide applications in the field of neuronal image super-resolution.

GRP-YOLOv5: An Improved Bearing Defect Detection Algorithm Based on YOLOv5.

Currently, most chemical transmission equipment relies on bearings to support rotating shafts and to transmit power. However, bearing defects can lead to a series of failures in the equipment, resulting in reduced production efficiency. To prevent such occurrences, this paper proposes an improved bearing defect detection algorithm based on YOLOv5. Firstly, to mitigate the influence of the similarity between bearing defects and non-defective regions on the detection performance, gamma transformation is introduced in the preprocessing stage of the model to adjust the image's grayscale and contrast. Secondly, to better capture the details and semantic information of the defects, this approach incorporates the ResC2Net model with a residual-like structure during the feature-extraction stage, enabling more nonlinear transformations and channel interaction operations so as to enhance the model's perception and representation capabilities of the defect targets. Additionally, PConv convolution is added in the feature fusion part to increase the network depth and better capture the detailed information of defects while maintaining time complexity. The experimental results demonstrate that the GRP-YOLOv5 model achieves a mAP@0.5 of 93.5%, a mAP@0.5:0.95 of 52.7%, and has a model size of 25 MB. Compared to other experimental models, GRP-YOLOv5 exhibits excellent performance in bearing defect detection accuracy. However, the model's FPS (frames per second) performance is not satisfactory. Despite its small size of 25 MB, the processing speed is relatively slow, which may have some impact on real-time or high-throughput applications. This limitation should be considered in future research and in the optimization efforts to improve the overall performance of the model.

A Novel Temporal Network-Embedding Algorithm for Link Prediction in Dynamic Networks.

Understanding the evolutionary patterns of real-world complex systems such as human interactions, biological interactions, transport networks, and computer networks is important for our daily lives. Predicting future links among the nodes in these dynamic networks has many practical implications. This research aims to enhance our understanding of the evolution of networks by formulating and solving the link-prediction problem for temporal networks using graph representation learning as an advanced machine learning approach. Learning useful representations of nodes in these networks provides greater predictive power with less computational complexity and facilitates the use of machine learning methods. Considering that existing models fail to consider the temporal dimensions of the networks, this research proposes a novel temporal network-embedding algorithm for graph representation learning. This algorithm generates low-dimensional features from large, high-dimensional networks to predict temporal patterns in dynamic networks. The proposed algorithm includes a new dynamic node-embedding algorithm that exploits the evolving nature of the networks by considering a simple three-layer graph neural network at each time step and extracting node orientation by using Given's angle method. Our proposed temporal network-embedding algorithm, TempNodeEmb, is validated by comparing it to seven state-of-the-art benchmark network-embedding models. These models are applied to eight dynamic protein-protein interaction networks and three other real-world networks, including dynamic email networks, online college text message networks, and human real contact datasets. To improve our model, we have considered time encoding and proposed another extension to our model, TempNodeEmb++. The results show that our proposed models outperform the state-of-the-art models in most cases based on two evaluation metrics.

Research on epidemic spread model based on cold chain input.

In recent years, the new type of coronary pneumonia (COVID-19) has become a highly contagious disease worldwide, posing a serious threat to the public health. This paper is based on the SEIR model of the new coronavirus pneumonia, considering the impact of cold chain input and re-positive on the spread of the virus in the COVID-19. In the process of model design, the food cold chain and re-positive are used as parameters, and its stability is analyzed and simulated. The experimental results show that taking into account the cold chain input and re-positive can effectively simulate the spread of the epidemic. The research results have important research value and practical significance for the prevention and control of the COVID-19 and the prediction of important time nodes.

Personalized Sliding Window Recommendation Algorithm Based on Sequence Alignment.

With the explosive growth of the amount of information in social networks, the recommendation system, as an application of social networks, has attracted widespread attention in recent years on how to obtain user-interested content in massive data. At present, in the process of algorithm design of the recommending system, most methods ignore structural relationships between users. Therefore, in this paper, we designed a personalized sliding window for different users by combining timing information and network topology information, then extracted the information sequence of each user in the sliding window and obtained the similarity between users through sequence alignment. The algorithm only needs to extract part of the data in the original dataset, and the time series comparison shows that our method is superior to the traditional algorithm in recommendation Accuracy, Popularity, and Diversity.

An Empirical Mode Decomposition Fuzzy Forecast Model for COVID-19.

At present, the Corona Virus Disease 2019 (COVID-19) is ravaging the world, bringing great impact on people's life safety and health as well as the healthy development of economy and society, so the research on the prediction of the development trend of the epidemic is crucial. In this paper, we focus on the prevention and control of epidemic using the relevant technologies in the field of artificial intelligence and signal analysis. With the unknown principle of epidemic transmission, we first smooth out the complex and variable epidemic data through the empirical mode decomposition model to obtain the change trends of epidemic data at different time scales. On this basis, the change trends under different time scales are trained using an extreme learning machine to obtain the corresponding prediction values, and finally the epidemic prediction results are obtained by fitting through Adaptive Network-based Fuzzy Inference System. The experimental results show that the algorithm has good learning ability, especially in the prediction of time-series sequences can guarantee the accuracy rate while having low time complexity. Therefore, this paper not only plays a theoretical support for epidemic prevention and control, but also plays an important role in the construction of public emergency health system in the long run.

Pattern formation in a four-ring reaction-diffusion network with heterogeneity.

In networks of nonlinear oscillators, symmetries place hard constraints on the system that can be exploited to predict universal dynamical features and steady states, providing a rare generic organizing principle for far-from-equilibrium systems. However, the robustness of this class of theories to symmetry-disrupting imperfections is untested in free-running (i.e., non-computer-controlled) systems. Here, we develop a model experimental reaction-diffusion network of chemical oscillators to test applications of the theory of dynamical systems with symmeries in the context of self-organizing systems relevant to biology and soft robotics. The network is a ring of four microreactors containing the oscillatory Belousov-Zhabotinsky reaction coupled to nearest neighbors via diffusion. Assuming homogeneity across the oscillators, theory predicts four categories of stable spatiotemporal phase-locked periodic states and four categories of invariant manifolds that guide and structure transitions between phase-locked states. In our experiments, we observed that three of the four phase-locked states were displaced from their idealized positions and, in the ensemble of measurements, appeared as clusters of different shapes and sizes, and that one of the predicted states was absent. We also observed the predicted symmetry-derived synchronous clustered transients that occur when the dynamical trajectories coincide with invariant manifolds. Quantitative agreement between experiment and numerical simulations is found by accounting for the small amount of experimentally determined heterogeneity in intrinsic frequency. We further elucidate how different patterns of heterogeneity impact each attractor differently through a bifurcation analysis. We show that examining bifurcations along invariant manifolds provides a general framework for developing intuition about how chemical-specific dynamics interact with topology in the presence of heterogeneity that can be applied to other oscillators in other topologies.

Efficacy of Morphine Combined with Mechanical Ventilation in the Treatment of Heart Failure with Cardiac Magnetic Resonance Imaging under Artificial Intelligence Algorithms.

This study was aimed at exploring the efficacy of morphine combined with mechanical ventilation in the treatment of heart failure with artificial intelligence algorithms. The cardiac magnetic resonance imaging (MRI) under the watershed segmentation algorithm was proposed, and the local grayscale clustering watershed (LGCW) model was designed in this study. A total of 136 patients with acute left heart failure were taken as the research objects and randomly divided into the control group (conventional treatment) and the experimental group (morphine combined with mechanical ventilation), with 68 cases in each group. The left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-proBNP), arterial partial pressure of oxygen (PaO2), and arterial partial pressure of carbon dioxide (PaCO2) were observed. The results showed that the mean absolute deviation (MAD) and maximum mean absolute deviation (max-MAD) of the LGCW model were lower than those of the fuzzy k-nearest neighbor (FKNN) algorithm and local gray-scale clustering model (LGSCm). The Dice metric was also significantly higher than that of other algorithms with statistically significant differences (P < 0.05). After treatment, LVEDD, LVESD, and NT-proBNP of patients in the experimental group were significantly lower than those in the control group, and LVEF in the experimental group was higher than that in the control group (P < 0.05). PaO2 of patients in the experimental group was also significantly higher than that in the control group (P < 0.05). It suggested that the LGCW model had a better segmentation effect, and morphine combined with mechanical ventilation gave a better clinical efficacy in the treatment of acute left heart failure, improving the patients' cardiac function and arterial blood gas effectively.

Ensemble of coupling forms and networks among brain rhythms as function of states and cognition.

The current paradigm in brain research focuses on individual brain rhythms, their spatiotemporal organization, and specific pairwise interactions in association with physiological states, cognitive functions, and pathological conditions. Here we propose a conceptually different approach to understanding physiologic function as emerging behavior from communications among distinct brain rhythms. We hypothesize that all brain rhythms coordinate as a network to generate states and facilitate functions. We analyze healthy subjects during rest, exercise, and cognitive tasks and show that synchronous modulation in the micro-architecture of brain rhythms mediates their cross-communications. We discover that brain rhythms interact through an ensemble of coupling forms, universally observed across cortical areas, uniquely defining each physiological state. We demonstrate that a dynamic network regulates the collective behavior of brain rhythms and that network topology and links strength hierarchically reorganize with transitions across states, indicating that brain-rhythm interactions play an essential role in generating physiological states and cognition.

Polyp Detection from Colorectum Images by Using Attentive YOLOv5.

BACKGROUND: High-quality colonoscopy is essential to prevent the occurrence of colorectal cancers. The data of colonoscopy are mainly stored in the form of images. Therefore, artificial intelligence-assisted colonoscopy based on medical images is not only a research hotspot, but also one of the effective auxiliary means to improve the detection rate of adenomas. This research has become the focus of medical institutions and scientific research departments and has important clinical and scientific research value. METHODS: In this paper, we propose a YOLOv5 model based on a self-attention mechanism for polyp target detection. This method uses the idea of regression, using the entire image as the input of the network and directly returning the target frame of this position in multiple positions of the image. In the feature extraction process, an attention mechanism is added to enhance the contribution of information-rich feature channels and weaken the interference of useless channels; Results: The experimental results show that the method can accurately identify polyp images, especially for the small polyps and the polyps with inconspicuous contrasts, and the detection speed is greatly improved compared with the comparison algorithm. CONCLUSIONS: This study will be of great help in reducing the missed diagnosis of clinicians during endoscopy and treatment, and it is also of great significance to the development of clinicians' clinical work.

Application of network link prediction in drug discovery.

BACKGROUND: Technological and research advances have produced large volumes of biomedical data. When represented as a network (graph), these data become useful for modeling entities and interactions in biological and similar complex systems. In the field of network biology and network medicine, there is a particular interest in predicting results from drug-drug, drug-disease, and protein-protein interactions to advance the speed of drug discovery. Existing data and modern computational methods allow to identify potentially beneficial and harmful interactions, and therefore, narrow drug trials ahead of actual clinical trials. Such automated data-driven investigation relies on machine learning techniques. However, traditional machine learning approaches require extensive preprocessing of the data that makes them impractical for large datasets. This study presents wide range of machine learning methods for predicting outcomes from biomedical interactions and evaluates the performance of the traditional methods with more recent network-based approaches. RESULTS: We applied a wide range of 32 different network-based machine learning models to five commonly available biomedical datasets, and evaluated their performance based on three important evaluations metrics namely AUROC, AUPR, and F1-score. We achieved this by converting link prediction problem as binary classification problem. In order to achieve this we have considered the existing links as positive example and randomly sampled negative examples from non-existant set. After experimental evaluation we found that Prone, ACT and [Formula: see text] are the top 3 best performers on all five datasets. CONCLUSIONS: This work presents a comparative evaluation of network-based machine learning algorithms for predicting network links, with applications in the prediction of drug-target and drug-drug interactions, and applied well known network-based machine learning methods. Our work is helpful in guiding researchers in the appropriate selection of machine learning methods for pharmaceutical tasks.

Research on multi-effect evaporation salt prediction based on feature extraction.

In the multi-effect evaporation salt making process, the smooth operation of the salt making process is crucial. As the salt production process continues, many unstable factors will cause the salt production process not to proceed smoothly. These factors can be discovered in advance by predicting the salt production data, thus, it is of great significance to predict the multi-effect evaporation salt production data. In the process of multi-effect evaporation and salt production, the multiple salt-making devices make the influence between the parameters closer, and the influence of a single parameter on itself is sometimes ductile. Therefore, the data of multi-effect evaporation and salt production have the characteristics of high dimensions, high complexity and temporal information. If the historical salt production data is used for data prediction directly, the prediction model will take a long time and the prediction effect is not good. Thus, how to predict the multi-effect evaporation salt production data is the main research problem of this paper. In view of the above problems, according to the characteristics of multi-effect evaporation salt production data, this paper analyzes and improves the self encoder for feature extraction of multi effect-evaporation salt production data, so as to solve the problem of high dimensions and high complexity of salt production data. On this basis, combined with the time-series information contained in the salt production data, a multi-effect evaporation salt production data prediction model is proposed based on long-term and short-term memory cycle neural network to solve the prediction problem of time-series salt production data. Experiments show that the prediction model can predict and prevent the problems in salt production line in advance. It has a certain theoretical research value and application value in the intelligent production process and production line optimization of salt chemical industry.

Attractor-state itinerancy in neural circuits with synaptic depression.

Neural populations with strong excitatory recurrent connections can support bistable states in their mean firing rates. Multiple fixed points in a network of such bistable units can be used to model memory retrieval and pattern separation. The stability of fixed points may change on a slower timescale than that of the dynamics due to short-term synaptic depression, leading to transitions between quasi-stable point attractor states in a sequence that depends on the history of stimuli. To better understand these behaviors, we study a minimal model, which characterizes multiple fixed points and transitions between them in response to stimuli with diverse time- and amplitude-dependencies. The interplay between the fast dynamics of firing rate and synaptic responses and the slower timescale of synaptic depression makes the neural activity sensitive to the amplitude and duration of square-pulse stimuli in a nontrivial, history-dependent manner. Weak cross-couplings further deform the basins of attraction for different fixed points into intricate shapes. We find that while short-term synaptic depression can reduce the total number of stable fixed points in a network, it tends to strongly increase the number of fixed points visited upon repetitions of fixed stimuli. Our analysis provides a natural explanation for the system's rich responses to stimuli of different durations and amplitudes while demonstrating the encoding capability of bistable neural populations for dynamical features of incoming stimuli.

A novel scheme for essential protein discovery based on multi-source biological information.

Mining essential protein is crucial for discovering the process of cellular organization and viability. At present, there are many computational methods for essential proteins detecting. However, these existing methods only focus on the topological information of the networks and ignore the biological information of proteins, which lead to low accuracy of essential protein identification. Therefore, this paper presents a new essential proteins prediction strategy, called DEP-MSB which integrates a variety of biological information including gene expression profiles, GO annotations, and Domain interaction strength. In order to evaluate the performance of DEP-MSB, we conduct a series of experiments on the yeast PPI network and the experimental results have shown that the proposed algorithm DEP-MSB is more superior to the other existing traditional methods and has obviously improvement in prediction accuracy.

An Early Intestinal Cancer Prediction Algorithm Based on Deep Belief Network.

The incidence of colorectal cancer (colorectal cancer, CRC) in China has increased in recent years, and its mortality rate has become one of the highest among all cancers. CRC also increasingly affects people's health and quality of life, and the workloads of medical doctors have further increased due to the lack of sufficient medical resources in China. The goal of this study was to construct an automated expert system using a deep learning technique to predict the probability of early stage CRC based on the patient's case report and the patient's attributes. Compared with previous prediction methods, which are either based on sophisticated examinations or have high computational complexity, this method is shown to provide valuable information such as suggesting potentially important early signs to assist in early diagnosis, early treatment and prevention of CRC, hence helping medical doctors reduce the workloads of endoscopies and other treatments.