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Adv Healthc Mater ; 12(24): e2300666, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-37216966

RESUMO

The native extracellular matrix is highly dynamic with continuous mutual feedback between cells being responsible for many important cell function regulators. However, establishing bidirectional interaction between complex adaptive microenvironments and cells remains elusive. Herein an adaptive biomaterial based on lysozyme monolayers self-assembled at a perfluorocarbon FC40-water interface is reported. The dynamic adaptivity of interfacially assembled protein nanosheets is modulated independently of bulk mechanical properties by covalent crosslinking. This provides a scenario to establish bidirectional interactions of cells with liquid interfaces of varying dynamic adaptivity. This is found that growth and multipotency of human mesenchymal stromal cells (hMSCs) are enhanced at the highly adaptive fluid interface. The multipotency retention of hMSCs is mediated by low cell contractility and metabolomic activity involving the continuous mutual feedback between the cells and materials. Consequently, an understanding of the cells' response to dynamic adaptivity has substantial implications for regenerative medicine and tissue engineering.


Assuntos
Células-Tronco Mesenquimais , Proteínas , Humanos , Diferenciação Celular/fisiologia , Proteínas/metabolismo , Materiais Biocompatíveis/metabolismo , Engenharia Tecidual , Células-Tronco Mesenquimais/metabolismo
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