RESUMO
The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA kits. The concentration of afamin was found to be significantly lower in patients with compensated alcoholic liver cirrhosis, i.e. P-Ch B (85.1±40.6 µg/ml) and P-Ch C (56.4±32.3 µg/ml) individuals, compared to the control group (135.9±43.6 µg/ml); p-value was <0.01 and <0.001, respectively. As far as adropin is concerned, a reverse relationship was demonstrated: the highest concentration was found in patients with P-Ch C (11.7±5.7 ng/ml) cirrhosis. Furthermore, the above concentration was significantly higher compared to patients with P-Ch A cirrhosis (7.2±2.8 ng/ml; p<0.05) and controls (7.5±2.6 ng/ml; p<0.05). The concentration of afamin decreases with the severity of alcoholic liver cirrhosis, which most likely results from impaired hepatic synthesis. Otherwise, the higher the stage of disease according to the Child-Pugh score, the higher the concentration of adropin.
Assuntos
Proteínas de Transporte/sangue , Glicoproteínas/sangue , Cirrose Hepática Alcoólica/sangue , Peptídeos/sangue , Adulto , Álcoois/efeitos adversos , Álcoois/metabolismo , Proteínas Sanguíneas/genética , Proteínas de Transporte/genética , Estudos de Casos e Controles , Feminino , Glicoproteínas/genética , Humanos , Peptídeos e Proteínas de Sinalização Intercelular , Cirrose Hepática Alcoólica/diagnóstico por imagem , Cirrose Hepática Alcoólica/etiologia , Cirrose Hepática Alcoólica/genética , Masculino , Pessoa de Meia-Idade , Peptídeos/genética , Polônia , Albumina Sérica Humana/genética , Índice de Gravidade de Doença , Ultrassonografia , Adulto JovemRESUMO
Postobstructive pulmonary edema is life-threatening, and results from a sudden episode of upper airway obstruction. Croup is generally thought to be a benign condition, but occasionally it can develop into postobstructive pulmonary edema. We present a case of a 5-year-old boy with recurrent croup, who was diagnosed with postobstructive pulmonary edema. Our experience alerts pediatricians to this easily misdiagnosed disease.