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1.
Sci Total Environ ; 934: 173280, 2024 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-38768721

RESUMO

Simulating the timing of leaf fall in large scale is crucial for accurate estimation of ecosystem carbon sequestration. However, the limited understanding of leaf senescence mechanisms often impedes the accuracy of simulation and prediction. In this study, we employed the advanced process-based models to fit remote sensing-derived end dates of the growing season (EOS) across deciduous broadleaf forests in the Northern Hemisphere, and revealed the spatial pattern associated with two leaf senescence pathways (i.e., either photoperiod- or temperature- initiated leaf senescence) and their potential effects on EOS prediction. The results show that the pixel-specific optimum models effectively fitted all EOS time series. Leaf senescence in 67.6 % and 32.4 % of pixels was initiated by shortening daylength and declining temperature, respectively. Shortening daylength triggered leaf senescence occurs mainly in areas with shorter summer daylength and/or warmer autumns, whereas declining temperature induced leaf senescence appears primarily in areas with longer summer daylength and/or colder autumns. The strong dependence of leaf senescence initiation cues on local temperature conditions implies that the ongoing increase in autumn temperature has the potential to alter the leaf senescence initiation, shifting from temperature cues to photoperiod signals. This shift would occur in 26.2-49.6 % of the areas where leaf senescence is initiated by declining temperature under RCP 4.5 and 8.5 scenarios, while forest areas where leaf senescence is induced by shortening daylength may expand northward. The overall delaying of the currently predicted EOS would therefore slow down by 4.5-10.3 % under the two warming scenarios. This implies that the adaptive nature of plants will reduce the overestimation of changes in carbon exchange capacity between ecosystems and atmosphere. Our study offers novel insights into understanding the mechanism of leaf senescence and improving the estimation of autumn phenology and ecosystem carbon balance in the deciduous broadleaf forests.


Assuntos
Florestas , Folhas de Planta , Estações do Ano , Temperatura , Folhas de Planta/fisiologia , Senescência Vegetal , Árvores/fisiologia , Tecnologia de Sensoriamento Remoto , Sequestro de Carbono , Fotoperíodo
2.
Sci Total Environ ; 929: 172553, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38663615

RESUMO

As a sensitive indicator of climate change and a key variable in ecosystem surface-atmosphere interaction, vegetation phenology, and the growing season length, as well as climatic factors (i.e., temperature, precipitation, and sunshine duration) are widely recognized as key factors influencing vegetation productivity. Recent studies have highlighted the importance of soil moisture in regulating grassland productivity. However, the relative importance of phenology, climatic factors, and soil moisture to plant species-level productivity across China's grasslands remains poorly understood. Here, we use nearly four decades (1981 to 2018) of in situ species-level observations from 17 stations distributed across grasslands in China to examine the key mechanisms that control grassland productivity. The results reveal that soil moisture is the strongest determinant of the interannual variability in grassland productivity. In contrast, the spring/autumn phenology, the length of vegetation growing season, and climate factors have relatively minor impacts. Generally, annual aboveground biomass increases by 3.9 to 25.3 g∙m2 (dry weight) with a 1 % increase in growing season mean soil moisture across the stations. Specifically, the sensitivity of productivity to moisture in wetter and colder environments (e.g., alpine meadows) is significantly higher than that in drier and warmer environments (e.g., temperate desert steppes). In contrast, the sensitivity to the precipitation of the latter is greater than the former. The effect of soil moisture is the most pronounced during summer. Dominant herb productivity is more sensitive to soil moisture than the others. Moreover, multivariate regression analyses show that the primary climatic factors and their attributions to variations in soil moisture differ among the stations, indicating the interaction between climate and soil moisture is very complex. Our study highlights the interspecific difference in the soil moisture dependence of grassland productivity and provides guidance to climate change impact assessments in grassland ecosystems.


Assuntos
Mudança Climática , Pradaria , Solo , China , Solo/química , Estações do Ano , Monitoramento Ambiental , Biomassa , Clima
3.
Int J Biometeorol ; 67(9): 1409-1421, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37479847

RESUMO

Evaluating the interactions between cold requirements for leaf coloration and environmental cues is crucial for understanding the mechanisms of leaf senescence and accurately predicting autumn phenology. Based on remote sensing-derived and ground-observed leaf coloration dates for deciduous broadleaf forests during 1981-2014, we determined location-specific cold requirements for autumn leaf coloration and assessed their spatiotemporal changes. Then, we revealed the major environmental cues of cold requirements and their spatial differentiation. Results show that cold requirements have nonsignificant trends during the past decades at 57.9% of pixels. The interannual variation of cold requirements was mainly influenced by growing-season accumulated temperature (GDDgs) at 35.8% of pixels and accumulated growing season index (AGSI) at 23.2% of pixels, but less affected by leaf unfolding and low precipitation index (LPI). The increase in GDDgs or AGSI may decrease cold requirements, and vice versa. The spatial differentiations of the effects of GDDgs and AGSI depend highly on local summer temperature among climatic classifications with similar humidity conditions. Specifically, the effects of GDDgs on cold requirements concentrated in humid regions with warmer summers, while that of AGSI mainly occurred in humid and winter dry regions with cooler summers. Higher summer temperatures would strengthen the effects of GDDgs and reduce the effects of AGSI on cold requirements. These findings deepen the understanding of the influences of environmental factors on leaf senescence progress and suggest that the shifts of factors affecting cold requirements under global warming may enlarge the uncertainty in predicting autumn leaf coloration dates.


Assuntos
Sinais (Psicologia) , Árvores , Florestas , Estações do Ano , Temperatura , Folhas de Planta , Mudança Climática
4.
Front Plant Sci ; 14: 1327509, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38273945

RESUMO

Climate warming has induced significant shifts in spring phenology over both temperate and boreal forests. The timing of bud growth resuming from dormancy is crucial for predicting spring phenology. However, the mechanisms by which environmental cues, other than chilling accumulation, initiate bud growth remains unclear. By constructing a revised process-based spring phenology model incorporating photoperiod and temperature triggers of bud growth, we simulated the first leaf unfolding and first flowering dates of four deciduous forest trees during 1981-2014 at 102 stations across China's monsoon regions. Then, we revealed spatial patterns of the two triggers. Moreover, we compared fitting precision and robustness of the revised model with three mainstream models. Results show that the revised models can effectively simulate all spring phenology time series. Growth initiation of foliar and floral buds was induced by photoperiod lengthening in 80.8% and 77.7% of time series, and by temperature increasing in remaining 19.2% and 22.3% of time series, respectively. The proportions of time series with photoperiod- and temperature-initiated bud growth significantly increase and decrease from northern to southern climatic zones, respectively. Chilling exposure controls the predominant bud growth triggers in different climate zones. Specifically, in regions with long and severe winters where chilling requirement is easily fulfilled, rising temperature in spring alleviates the cold constraint and initiate bud growth. Conversely, in regions with short and mild winters, prolonged daylength in spring compensates the lack of chilling exposure to initiate bud growth. These findings suggest that photoperiod may limit spring phenology response to temperature in low-latitudes. Overall, our model slightly outperforms other models in terms of efficiency, accuracy, and robustness in modeling leaf unfolding and flowering dates. Therefore, this study deepens our understanding of the mechanisms of spring phenology, and improves the predicting capability of spring phenology models in the face of ongoing global warming.

5.
ACS Appl Mater Interfaces ; 14(22): 25680-25692, 2022 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-35605189

RESUMO

The accelerated evolution of the Internet of Things has brought new challenges to the gas sensors, which are required to work persistently under harsh conditions, like high humidity. However, currently, it is quite challenging to solve the hindrance of the trade-off between gas-sensing performance and anti-humidity ability of the chemiresistive gas sensors. Herein, hydrophobic inorganic CeO2/SnO2 heterostructure films were prepared by depositing the CeO2 layers with a thickness of a few nanometers onto the SnO2 film via a magnetron sputtering method. The sensors based on the CeO2/SnO2 heterostructure films demonstrated excellent gas-sensing performance toward trimethylamine (TEA) with high response, wide detection range (0.04-500 ppm), low record detection limit (0.04 ppm), ideal reproducibility, and long-term stability, while concurrently possessing promising anti-humidity ability. A portable, wireless TEA-sensing system containing the CeO2/SnO2 sensor was constructed to realize the real-time monitoring of trace concentration of the volatiles released from a fish. This work provides a novel strategy to prepare advanced chemiresistive gas sensors for humidity-independent detection of harmful gases and vapors and will accelerate their commercialization process in the field of food safety and public health.

6.
Front Plant Sci ; 13: 844971, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35392512

RESUMO

The phenology of alpine grassland on the Qinghai-Tibet Plateau (QTP) is critical to regional climate change through climate-vegetation feedback. Although many studies have examined QTP vegetation dynamics and their climate sensitivities, the interspecific difference in the phenology response to climate change between alpine species is poorly understood. Here, we used a 30-year (1989-2018) record of in situ phenological observation for five typical alpine herbs (Elymus nutans, Kobresia pygmaea, Plantago asiatica, Puccinellia tenuiflora, and Scirpus distigmaticus) and associated climatic records at Henan Station in the eastern QTP to examine the species-level difference in spring and autumn phenology and then quantify their climate sensitivities. Our results show that with significantly warming, the green-up dates of herbs were insignificantly shifted, while the brown-off dates in four out of the five herbs were significantly delayed. Meanwhile, the interspecific difference in brown-off dates significantly increased at a rate of 0.62 days/annual from 1989 to 2016, which was three times larger than that in green-up dates (0.20 days/annual). These diverse rates were attributed to the different climate controls on spring and autumn phenology. In particular, green-up dates in most herbs were sensitive to mean surface temperature, while brown-off dates were sensitive to the night surface temperature. Furthermore, brown-off dates are less sensitive to the warming in high ecological niche (with higher herb height and aboveground biomass) herbs than low niche herbs (with lower herb height and aboveground biomass). The increased phenology interspecific difference highlights the complex responses of herbs to future climate change even under the same alpine environment and indicates a potential alternation in the plants community of alpine QTP, which may further influence the regional climate-vegetation feedback.

7.
Materials (Basel) ; 15(5)2022 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-35268999

RESUMO

Wearable energy harvesters and sensors have recently attracted significant attention with the rapid development of artificial intelligence and the Internet of Things (IoT). Compared to high-output bulk materials, these wearable devices are mainly fabricated by thin-film-based materials that limit their application. Therefore, the enhancement of output voltage and power for these devices has recently become an urgent topic. In this paper, the lead-free bismuth titanate-barium titanate (0.93(Na0.5Bi0.5)TiO3-0.07BaTiO3(BNBT)) nanoparticles and nanofibers were embedded into the PVDF nanofibers. They produced high inorganic electrical voltage coefficients, high electromechanical coupling coefficients, and environmentally friendly properties that enhance the electromechanical performance of pure PVDF nanofibers, and they are all the critical requirements for modern flexible pressure sensors. In detail, PVDF and PVDF-based composites nanofibers were prepared by electrospinning, and different flexible sandwich composite devices were fabricated by the PDMS encapsulation method. As a result, the six-time enhancement maximum output voltage was obtained in a PVDF-BNBT (fiber)-based composite sensor compared to the pure PVDF one. Our results indicate that the output voltage of the pressure sensors has been significantly enhanced, and the development gate is enabled by analyzing the related physical process and influence mechanism.

8.
Infection ; 50(3): 739-746, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35013942

RESUMO

PURPOSE: We aimed to explore the association between urinary tract infection (UTI) in adults and serum 25-hydroxyvitamin D (25OHD), which was used to access vitamin D status. METHODS: Serum levels of 25OHD were retrospectively analyzed in 234 subjects (190 females and 44 males): 120 UTI patients (females = 103) and 114 age- and sex-matched healthy controls (females = 87). Serum 25OHD concentrations were categorized as follows: (1) < 20 ng/mL, 20 to < 30 ng/mL, and ≥ 30 ng/mL; (2) < 20 ng/mL and ≥ 20 ng/mL. RESULTS: Serum 25OHD levels were lower in patients with UTI (p < 0.01). Women with UTI presented significantly lower 25OHD concentrations than those without UTI (p < 0.01). No association between serum 25OHD levels and UTI in men was found (p > 0.05). The multivariable logistic regression models showed significant associations between UTI and 25OHD, female sex, neutrophilic lymphocyte ratio and C-reactive protein (p < 0.05). CONCLUSION: Lower 25OHD concentrations associated with UTI were most prominent among women. The associations between UTI and low serum 25OHD levels as well as female sex were independent of each other.


Assuntos
Infecções Urinárias , Deficiência de Vitamina D , Vitamina D , Adulto , Proteína C-Reativa/metabolismo , Feminino , Humanos , Masculino , Estudos Retrospectivos , Infecções Urinárias/sangue , Vitamina D/sangue , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/microbiologia
9.
J Clin Med ; 12(1)2022 Dec 25.
Artigo em Inglês | MEDLINE | ID: mdl-36614968

RESUMO

Diabetic kidney disease (DKD) and primary glomerular disease (PGD) are the main causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD). This study was conducted to compare the characteristics of ambulatory blood-pressure monitoring (ABPM) and its relationship with target-organ damage (TOD) in patients with DKD and PGD matched by propensity score. The assessment of TOD included macroalbuminuria, left ventricular hypertrophy (LVH) and macrovascular disease. Propensity-score weighting (PSW) was used in stratified analysis. Results: Patients with DKD had a higher prevalence of abnormal blood-pressure patterns such as reversed dipper pattern, nocturnal hypertension, and sustained hypertension and had a higher prevalence of TOD than did patients with PGD. Logistic regression indicated that patients with DKD were more related to TOD than to PGD. The stratified analysis indicated that DKD patients with white-coat hypertension, masked hypertension and sustained hypertension had closer relationships with TOD compared with PGD patients. Conclusion: Patients with type 2 diabetic kidney disease had more abnormal blood-pressure patterns and were more closely related to target organ damage than were patients with primary glomerular disease.

10.
Ann Med ; 53(1): 2132-2141, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34779336

RESUMO

BACKGROUND: Biomarkers of oxidative stress (OS) have been poorly explored in fungal peritonitis (FP). Potassium is a regulator of pro-oxidants and antioxidants. Albumin and vitamin B12 (B12) are vital antioxidant agents in the circulatory system. This study aimed to investigate the antioxidative role of serum potassium, albumin and B12 in FP. METHODS: Serum levels of potassium, albumin and B12 were retrospectively analyzed in 21 patients with a confirmed diagnosis of FP, 105 bacterial peritonitis (BP) patients and 210 patients receiving peritoneal dialysis without peritonitis. RESULTS: Serum levels of potassium, albumin and B12 were lower in FP patients than in BP patients. Serum potassium concentration was statistically related to albumin concentration in peritonitis patients. Univariate and multivariate binary logistic regression analysis suggested that serum level of potassium and albumin were independent risk factors of FP when compared with BP. Lower potassium and B12 levels were independently associated with higher rates of technique failure in peritonitis. CONCLUSION: These findings suggest lower serum potassium, albumin and B12 as potential oxidative stress markers of FP and raise the hypothesis that an increased level of OS could contribute to FP.KEY MESSAGESFP remains a serious complication of peritoneal dialysis (PD), with higher morbidity (1-23.8%) and mortality (2-25%), and oxidative stress plays a role in it.Our study suggested serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis.


Assuntos
Micoses/diagnóstico , Peritonite/diagnóstico , Potássio/sangue , Albumina Sérica , Vitamina B 12/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Antifúngicos/uso terapêutico , Infecções Bacterianas/complicações , Biomarcadores/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Micoses/sangue , Micoses/complicações , Estresse Oxidativo/fisiologia , Peritonite/sangue , Peritonite/microbiologia , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
11.
Ren Replace Ther ; 7(1): 19, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33868717

RESUMO

BACKGROUND: During the outbreak of new coronavirus pneumonia, many hospitals in China became the designated hospitals for the treatment of new coronavirus pneumonia. The goal was to develop rapid and effective prevention and control methods for blood purification centers. RESEARCH DESIGN AND METHODS: The medical department, hospital department, nursing department, and blood purification center jointly set up a multi-department integrated COVID-19 prevention and control management team to manage the blood purification center. The efforts included the establishment of the continuous renal replacement therapy (CRRT) team for COVID-19, the integrated training and assessment of medical personnel, the integrated education of patients and their families, and the integrated management of the workflow of the hemodialysis room. RESULTS: No infected persons, including medical staff, patients, and their families, have been found in the dialysis center. After multi-departmental integrated training, the theoretical performance of medical staff in our dialysis center has increased from 82.36 ± 8.10 to 95.29 ± 4.95 (p < 0.05), and the unqualified rate dropped from 23.21 to 1.78% (p < 0.05). In addition, the three operational skills evaluation scores have also been significantly improved, from 86.00 ± 4.02, 88.01 ± 6.20, 92.01 ± 2.46 to 95.90 ± 0.30, 97.21 ± 0.87, 96.00 ± 1.00 (p < 0.01), and the passing rate from 80.36 to 100% (p < 0.05). CONCLUSION: Medical staff's knowledge of novel coronavirus pneumonia prevention and control can be improved by multi-sectoral integrated management, and CRRT treatment of COVID-19 patients is effective.

12.
J Clin Hypertens (Greenwich) ; 23(5): 1051-1059, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33682307

RESUMO

Both morning hypertension (MH) and nocturnal hypertension (NH) are associated with severe target organ damage in patients with chronic kidney disease (CKD). However, the isolated or combined effects of MH and NH on target organ damage are less well-defined. A cross-sectional study was conducted among 2386 non-dialysis CKD patients with ambulatory blood pressure monitoring. The authors categorized patients into four groups based on the presence or absence of MH and NH. Multivariate logistic analyses were used to evaluate the correlation between hypertension subtypes and target organ damage, including left ventricular hypertrophy (LVH), abnormal carotid intima-media thickness (CIMT), low estimated glomerular filtration rate (eGFR), and albuminuria. The percentages of isolated MH, isolated NH, and combined MH and NH were 2.3%, 24.0%, and 49.3%, respectively. Compared to patients without MH and NH, isolated MH was only related to low eGFR (2.26 [95% confidence interval: 1.00-5.09]) and albuminuria (2.17 [95% CI: 1.03-4.54]). Meanwhile, combined MH and NH group compared to the group without MH and NH had a higher risk of LVH (2.87 [95% CI: 2.01-4.09]), abnormal CIMT (2.01 [95% CI: 1.47-2.75]), low eGFR (3.18 [95% CI: 2.23-4.54]), and albuminuria (1.79 [95% CI: 1.33-2.40]), even in patients without daytime hypertension. The risk of cardiovascular and renal damage was also observed in the isolated NH group. In conclusion, morning hypertension is associated with kidney dysfunction and has combined effects with nocturnal hypertension on cardiovascular damage in chronic kidney disease patients.


Assuntos
Hipertensão , Insuficiência Renal Crônica , Pressão Sanguínea , Monitorização Ambulatorial da Pressão Arterial , Espessura Intima-Media Carotídea , Estudos Transversais , Humanos , Hipertensão/complicações , Hipertensão/epidemiologia , Prevalência , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/epidemiologia
13.
BMC Nephrol ; 21(1): 541, 2020 12 11.
Artigo em Inglês | MEDLINE | ID: mdl-33308181

RESUMO

BACKGROUND: Blood pressure is an important and modifiable cardiovascular risk factor. Ambulatory blood pressure monitoring (ABPM) provides valuable prognostic information in patients with chronic kidney disease (CKD), yet little is known about the association of various types of BP measurements with target organ damage (TOD) in patients with primary glomerular disease. The goal of this study was to investigate whether ambulatory blood pressure is better associated with TOD than clinic blood pressure in patients with primary glomerular disease. METHODS: 1178 patients with primary glomerular disease were recruited in this cross-sectional study. TOD were assessed by the following 4 parameters: left ventricular mass index (LVMI or LVH, left ventricular hypertrophy), estimated glomerular filtration rate (eGFR< 60 ml/min/1.73m2), albumin-to-creatinine ratio (ACR ≥ 30 mg/g) and carotid intima-media thickness (cIMT) or plaque. Receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used to evaluate the relationship between ambulatory or clinic systolic blood pressure (SBP) indexes and TOD. RESULTS: Among 1178 patients (mean age, 39 years,54% men), 116, 458, 1031 and 251 patients had LVH, eGFR < 60 ml/min/1.73m2, ACR ≥ 30 mg/g and cIMT≥0.9 mm or plaque respectively. Area under ROC curves for TOD in ambulatory SBP, especially nighttime SBP, was greater than that in clinic SBP (P < 0.05). Multivariate logistic regression analyses showed that 24 h SBP, daytime SBP and nighttime SBP were significantly associated with LVH, eGFR< 60 ml/min/1.73m2 and ACR ≥ 30 mg/g after adjustment for clinic SBP, while the association of clinic SBP was attenuated after further adjustment for nighttime SBP. CONCLUSIONS: Ambulatory blood pressure, especially nighttime blood pressure, is probably superior to clinic blood pressure and has a significant association with TOD in primary glomerular disease patients.


Assuntos
Monitorização Ambulatorial da Pressão Arterial , Doenças das Artérias Carótidas/epidemiologia , Taxa de Filtração Glomerular , Glomerulonefrite/fisiopatologia , Hipertensão/diagnóstico , Hipertrofia Ventricular Esquerda/epidemiologia , Placa Aterosclerótica/epidemiologia , Adulto , Doenças das Artérias Carótidas/etiologia , Espessura Intima-Media Carotídea , Creatinina/metabolismo , Feminino , Glomerulonefrite/complicações , Glomerulonefrite por IGA/complicações , Glomerulonefrite por IGA/fisiopatologia , Glomerulonefrite Membranoproliferativa/fisiopatologia , Glomerulonefrite Membranosa/complicações , Glomerulonefrite Membranosa/fisiopatologia , Glomerulosclerose Segmentar e Focal/fisiopatologia , Humanos , Hipertensão/complicações , Hipertensão/fisiopatologia , Hipertrofia Ventricular Esquerda/etiologia , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Nefrose Lipoide/complicações , Nefrose Lipoide/fisiopatologia , Placa Aterosclerótica/etiologia , Prognóstico , Insuficiência Renal Crônica/etiologia , Insuficiência Renal Crônica/fisiopatologia , Albumina Sérica/metabolismo , Adulto Jovem
14.
Cell Death Dis ; 11(9): 814, 2020 09 29.
Artigo em Inglês | MEDLINE | ID: mdl-32994406

RESUMO

Excessive mitochondrial fission plays a key role in podocyte injury in diabetic kidney disease (DKD), and long noncoding RNAs (lncRNAs) are important in the development and progression of DKD. However, lncRNA regulation of mitochondrial fission in podocytes is poorly understood. Here, we studied lncRNA maternally expressed gene 3 (Meg3) in mitochondrial fission in vivo and in vitro using human podocytes and Meg3 podocyte-specific knockdown mice. Expression of lncRNA Meg3 in STZ-induced diabetic mice was higher, and correlated with the number of podocytes. Excessive mitochondrial fission of podocytes and renal histopathological and physiological parameters were improved in podocyte-specific Meg3 knockdown diabetic mice. Elongated mitochondria with attenuated podocyte damage, as well as mitochondrial translocation of dynamin-related protein 1 (Drp1), were decreased in Meg3 knockout podocytes. By contrast, increased fragmented mitochondria, podocyte injury, and Drp1 expression and phosphorylation were observed in lncRNA Meg3-overexpressing podocytes. Treatment with Mdivi1 significantly blunted more fragmented mitochondria and reduced podocyte injury in lncRNA Meg3-overexpressing podocytes. Finally, fragmented mitochondria and Drp1 mitochondrial translocation induced by high glucose were reduced following treatment with Mdivi1. Our data show that expression of Meg3 in podocytes in both human cells and diabetic mice was higher, which regulates mitochondrial fission and contributes to podocyte injury through increased Drp1 and its translocation to mitochondria.


Assuntos
Glucose/metabolismo , Dinâmica Mitocondrial , Podócitos/metabolismo , RNA Longo não Codificante/metabolismo , Animais , Diabetes Mellitus Experimental/genética , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Experimental/patologia , Dinaminas/genética , Dinaminas/metabolismo , Humanos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Podócitos/patologia , RNA Longo não Codificante/biossíntese , RNA Longo não Codificante/genética
15.
Int J Biometeorol ; 64(11): 1911-1922, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32740667

RESUMO

Using leaf area index (LAI) data from 1981 to 2014 in the tropical moist forest eco-zone of South America, we extracted start (SOS) and end (EOS) dates of the active growing season in forest and savanna at each pixel. Then, we detected spatiotemporal characteristics of SOS and EOS in the two vegetation types. Moreover, we analyzed relationships between interannual variations of SOS/EOS and climatic factors, and simulated SOS/EOS time series based on preceding mean air temperature and accumulated rainfall. Results show that mean SOS and EOS ranged from 260 to 330 day of year (DOY) and from 150 to 260 DOY across the study region, respectively. From 1981 to 2014, SOS advancement is more extensive than SOS delay, while EOS advancement and delay are similarly extensive. For most pixels of forest and savanna in tropical moist forest eco-zone, preceding rainfall correlates predominantly negatively with SOS but positively with EOS, while the relationship between preceding temperature and phenophases is location-specific. In addition, preceding rainfall is more extensive than preceding temperature in simulating SOS, while both preceding rainfall and temperature play an important role for simulating EOS. This study highlights the reliability of using LAI data for long-term phenological analysis in the tropical moist forest eco-zone.


Assuntos
Florestas , Reprodutibilidade dos Testes , Estações do Ano , América do Sul , Temperatura
16.
Int J Biometeorol ; 64(9): 1549-1560, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32415618

RESUMO

Examining whether a phenophase occurrence date in the current year affects the same phenophase occurrence date in the following year is crucial for developing cross-year phenological prediction models. Here, we carried out correlation analyses between leaf unfolding start (LUS)/leaf fall end (LFE) dates in the current and following years for four dominant tree species in temperate northern China from 1981 to 2012. Then, we calculated the recurrence intervals of LUS and LFE between two adjacent years for each species. Moreover, we investigated temperature effects on LUS/LFE dates, growing season and non-growing season lengths. Results show that correlation coefficients between LUS/LFE dates in the current and following years are nonsignificant at most stations. The recurrence interval of a phenophase has slight interannual variation and correlates significantly (and negatively) with the phenophase occurrence date of the current year. Further analyses indicate that LUS dates correlate significantly (and negatively) with spring mean temperatures, while LFE dates correlate significantly (and positively) with autumn mean temperatures, but negatively with growing season mean temperatures. In addition, spring mean temperatures can influence growing season length by controlling LUS date but cannot influence the following non-growing season length. Similarly, autumn mean temperatures and growing season mean temperatures can influence the subsequent non-growing season length but cannot influence the growing season length of the following year. Our study highlights that recurrence interval and time restrictions in the effects of seasonal temperatures on phenophase dates are the main environmental causes of nonsignificant correlations between phenophase occurrence dates in the current and following years.


Assuntos
Folhas de Planta , Árvores , China , Mudança Climática , Estações do Ano , Temperatura
17.
Stud Health Technol Inform ; 264: 1835-1836, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31438367

RESUMO

Patients with olfactory disorders are often encountered with a complex workflow and unsatisfied results. This article explores an informatics application to manage olfactory disorders with clinical decision support. Evidence from PubMed was used to analyze and extract the workflow, according to the "five rights" CDS framework. Five focus points and corresponding tips were identified. This work provides disease analysis and life guidance for prediction of the occurrence of more serious diseases.


Assuntos
Sistemas de Apoio a Decisões Clínicas , Idoso , Humanos , Transtornos do Olfato , Fluxo de Trabalho
18.
Stud Health Technol Inform ; 264: 228-232, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31437919

RESUMO

Meta-analysis, a systematic retrieval from literature databases is an essential and prevailing method for combining data from multiple studies. Unfortunately, few studies have examined its rigor, which affects its reproducibility of results. We identified 22 meta-analyses on cervical cancer in PubMed for examining the parameters defined by PRISMA, relating to the rigor of literature retrieval. We found that 16 literature databases were used, and EMBASE was a leading resource, accounting for the highest frequency (81.82%). About half (45.45%) of the meta-analyses presented a complete, reproducible search strategy for at least one database. The ratio of included to retrieved articles after redundancy removal was only 6.58%, indicating low precision due to unclear or unreported processes. Our work serves as an initial step to examine the planning and execution of meta-analysis. Future efforts need to enhance reliability on literature retrieval in meta-analysis and compliance to PRISMA.


Assuntos
Recursos em Saúde , Armazenamento e Recuperação da Informação , Reprodutibilidade dos Testes , Bases de Dados Factuais , PubMed
19.
J Environ Sci (China) ; 80: 257-266, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30952343

RESUMO

Light-absorbing carbonaceous aerosols including black carbon (BC) and brown carbon (BrC) play significant roles in atmospheric radiative properties. One-year measurements of aerosol light absorption at multi-wavelength were continuously conducted in Xiamen, southeast of China in 2014 to determine the light absorption properties including absorption coefficients (σabs) and absorption Ångström exponent (AAE) in the coastal city. Light absorptions of BC and BrC with their contributions to total light absorption were further quantified. Mean σabs at 370 nm and 880 nm were 56.6 ±â€¯34.3 and 16.5 ±â€¯11.2 Mm-1, respectively. σabs presented a double-peaks diurnal pattern with the maximum in the morning and the minimum in the afternoon. σabs was low in warm seasons and high in cold seasons. AAE ranged from 0.26 to 2.58 with the annual mean of 1.46, implying that both fossil fuel combustion and biomass burning influenced aerosol optical properties. σabs of BrC at 370 nm was 24.0 ±â€¯5.7 Mm-1, contributing 42% to the total absorption. The highest AAE (1.52 ±â€¯0.02) and largest BrC contributions (47% ±â€¯4%) in winter suggested the significant influence of biomass burning on aerosol light absorption. Long-distance air masses passing through North China Plain and the Yangtze River Delta led to high AAE and BrC contributions. High AAE value of 1.46 in July indicated that long-range transport of the air pollutants from intense biomass burning in Southeast Asia would affect aerosol light absorption in Southeast China. The study will improve the understanding of light absorption properties of aerosols and the optical impacts of BrC in China.


Assuntos
Aerossóis/análise , Poluentes Atmosféricos/análise , Monitoramento Ambiental , Absorção Fisico-Química , China , Combustíveis Fósseis , Material Particulado
20.
Sci Total Environ ; 653: 496-503, 2019 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-30414579

RESUMO

Secondary organic aerosol (SOA) plays an important role in global climate change and air quality. PM2.5 (particles with aerodynamic diameters ≤2.5 µm) samples were collected at a mountainous forest site (Mt. Wuyi) in southeastern China between November 2015 and July 2016. Fourteen PM2.5-bound SOA tracers, including isoprene, α/ß­pinene, ß­caryophyllene, and toluene, were measured using the gas-chromatography-mass-spectrometry method. The total concentrations of the isoprene, α/ß­pinene, ß­caryophyllene, and toluene SOA tracers were 45.28 ±â€¯65.52, 30.66 ±â€¯24.44, 5.99 ±â€¯7.25, and 0.62 ±â€¯0.72 ng m-3, respectively. The isoprene SOA tracers exhibited the highest concentration (145.97 ±â€¯53.78 ng m-3) and accounted for 76 ±â€¯9% of the total concentration of SOA tracers in summer. In fall-winter, the mass fraction of 2­methylglyceric acid was significantly enhanced because of the lower temperature and higher NOx level. As later-generation products of α/ß­pinene tracers, high proportions of 3­hydroxyglutaric acid and 3­methyl­1,2,3 butanetricarboxylic acid were observed on Mt. Wuyi, suggesting that the aerosols were highly oxidized. Biomass burning events affected by local and regional sources were identified by analyzing typical SOA tracers. Significant positive correlation (R2 = 0.74) was found between the ß­caryophyllene tracer and levoglucosan. The average concentration of secondary organic carbon (SOC) as estimated from SOA tracers was 1.46 µgC m-3. The isoprene SOC accounted for 70% of the total SOC in summer, whereas the ß­caryophyllene SOC was the predominant component in winter. Meanwhile, the estimated toluene SOC accounted for 11.6% of the total SOC during the study period. The study helps understanding the characteristics and the formation of SOA in a mountainous forest area of southeastern China.

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