RESUMO
OBJECTIVE: To study the phamacokinetics and targeting characteristics of adriamyin in dogs following embolization of hepatic artery with adriamyin-lipiodol emulsion (AD-E). METHODS: After injection of adriamycin solution and the emulsion, respectively, into the hepatic artery via a femoral artery of the dogs, the concentration of adriamycin in the peripheral venous blood and hepatic tissue were determined by high-performance liquid chromatography. RESULTS: The concentration of adriamycin in peripheral venous blood was significantly lowered after AD-E embolization in comparison with that after adriamycin solution injection. Adriamycin concentration in the hepatic tissue at 10, 24, and 48 h after AD-E embolization was 5.42, 3.33 and 2.38 times that of adrimycin solution group, respectively. CONCLUSION: Compared to adriamycin solution, AD-E as an embolic agent can significantly alter the serum pharmacokinetics and liver targeting characteristics of adriamycin.