"The Sulfur Dance" Around Arenes and Heteroarenes - the Reversible Nature of Nucleophilic Aromatic Substitutions.

We disclose the features of a category of reversible nucleophilic aromatic substitutions in view of their significance and generality in dynamic aromatic chemistry. Exchange of sulfur components surrounding arenes and heteroarenes may occur at 25 °C, in a process that one may call a "sulfur dance". These SN Ar systems present their own features, apart from common reversible reactions utilized in dynamic covalent chemistry (DCC). By varying conditions, covalent dynamics may operate to provide libraries of thiaarenes with some selectivity, or conversion of a hexa(thio)benzene asterisk into another one. The reversible nature of SN Ar is confirmed by three methods: a convergence of the products distribution in reversible SN Ar systems, a related product redistribution between two per(thio)benzenes by using a thiolate promoter, and from kinetic/thermodynamic data. A four-component dynamic covalent system further illustrates the thermodynamically-driven formation of a thiacalix[2]arene[2]pyrimidine by sulfur component exchanges. This work stimulates the implementation of reversible SN Ar in aromatic chemistry and in DCC.

Assessing COVID-19 Health Literacy (CoHL) and its relationships with sociodemographic features, locus of control and compliance with social distancing rules during the first lockdown in France.

Health literacy (HL) is critical to find, understand and use health information for adopting appropriate health behavior, especially during a pandemic crisis in which people can be exposed to an overwhelming amount of information from different media. To this end, we conducted an online study to first validate the measure of COronaVIrus Disease appeared in 2019 (COVID-19) health literacy (CoHL) and then investigated its relationships with locus of control (LoC), news information search and the adoption of protective behaviors (PBs) during the first lockdown in France. We first showed the good structural and psychometric qualities of the CoHL scale on a 3-dimensional structure: the Critical dimension, the Extraction/Communicative and the Application/Communicative dimension. We then found that CoHL was associated with the adoption of PBs suggesting that people with higher CoHL tended to adopt more PBs during the first lockdown, regardless of their LoC. However, people with low CoHL would be more likely to adopt PBs if they believe that they may get COVID-19 due to the behavior and health conditions of others (high external LoC). The study has implications for the design of public health campaigns for people with inadequate HL and with a different LoC.

Cancer Pain and Patient Education: Strategy, Implementation, Difficulties and Opportunities of EFFADOL, a Regional Collaborative Programme.

While pain remains a burden for many cancer patients, their active involvement in dealing with it through therapeutic patient education (TPE) has proved effective in overcoming hurdles to pain management. This article describes how a regional TPE programme devoted to cancer pain was set up, as well as the difficulties and opportunities encountered during its implementation. Ten nurse-doctor pairs from the chronic pain units of Lower Normandy, after being trained in TPE, designed and built the EFFADOL (Ensemble Faire Face A la DOuLeur [Cope together with pain]) programme. They collaboratively developed the pedagogical, evaluation and communication tools used in the programme. After the educational diagnosis step, patients are able to follow three sessions in order to acquire the following skills: (1) understanding the different types of pain, (2) understanding pain treatments and their adverse reactions and (3) optimally managing pain on a daily basis. Patients can ask a relative to join the sessions and can choose their preferred modality (individual and/or collective sessions). Programme implementation and the importance of communicating with oncologists and independent health professionals are discussed. The programme, which is available to patients close to home, meets their needs as previously assessed through a regional prospective survey. Difficulties to include patients and opportunities to address them are identified. The programme's limitations mainly concern its organization, structure and communication issues. The main challenge remains the overhaul of care practices and the role of the caregiver to allow patient autonomy.

Phase transfer of metal cations by induced dynamic carrier agents: biphasic extraction based on dynamic covalent chemistry.

In contrast to the classical method where a single molecule is designed to extract metal cations under specific conditions, dynamic covalent chemistry provides an approach based on the implementation of an adaptive dynamic covalent library for inducing the generation of the extractant species. This approach has been applied to the liquid-liquid extraction of copper(ii) nitrate based on a dynamic library of acylhydrazones constituents that self-build and distribute through the interface of a biphasic system. The addition of copper(ii) cations to this library triggers a modification of its composition and the up-regulation of the ligand molecules driven by coordination to the metal cations. Among these, one species has proven to be sufficiently lipophilic to play the role of carrier agent and its formation by component exchange enables the partial extraction of the copper(ii). The study of different pathways to generate the dynamic covalent library demonstrates the complete reversibility and the adaptability of the system. The detailed analytical investigation of the system provides a means to assess the mechanism of the dynamic extraction process.

Data on public bicycle acceptance among Chinese university populations.

This data article provides the data related to the research article entitled "Bicycle acceptance on campus: Influence of the built environment and shared bikes" (Chevalier et al., 2018) [1]. The data is the combination of two distinct datasets: (i) the built-environmental characteristics of the cycling environment and (ii) the answers of 1131 respondents to a structured questionnaire on public bicycle acceptance collected via an on-line survey platform. The survey took place in 2018 and gather respondents spread over five different university campuses in Shanghai (China). The data provides detailed information on individual perception of bicycles in general and Dock-less App-based Shared Bike (DASB) systems in particular. The dataset related to the questionnaire can be split into three types of data; (i) the personal profile and respondent's preferences in terms of transportation; (ii) the perception of cycling and cyclists at a city level and (iii) this perception restricted to the campus area. The association of the cycling environment characteristics and the individual perception of bicycles displayed in each group allow different levels of data analysis to explore the relationship between the built environment and the public acceptance of both the bicycle in general and the DASB in particular.

[Elaboration and evaluation of a therapeutic education program in cancer pain management]. / Construction et évaluation d'un programme d'éducation thérapeutique du patient dans le domaine de la douleur liée au cancer.

Pain, one of the most feared symptoms for patients with cancer, remains insufficiently alleviated and impairs quality of life. Therapeutic patient education (TPE) is a relevant approach to this problem while allowing patients to develop skills to better manage their pain. In the "Basse-Normandie" French region, the management of pain relies on two organized networks, thus allowing proximity and accessibility for all concerned. In this context, our team has begun a broad five-step research program that is part of a regional health policy: (1) training in TPE of 10 doctor/nurse pairs; (2) identification of educational expectations of patients and their relatives in the field of cancer pain; (3) design and optimization of a TPE program dedicated to cancer pain; (4) regional pilot study aiming to assess the feasibility, quality and transferability of the program; (5) evaluation of the TPE program by interventional comparative randomization at the national level. This article aims to present the program which originality and strengths are based on collaborative work between health stakeholders. Objectives, methodology and expected results of the research phase (stages 2, 4, 5) are notably developed. The main expected outcomes are to prove the effectiveness of the program in improving the knowledge and skills of patients in the field of pain cancer in order to promote their adherence to treatment and, consequently, to enable them to better manage it. The long-term objective is to disseminate the educational approach by modifying practices that provide a mutual benefit for caregivers and patients.

Therapeutic Patient Education in Cancer Pain Management: from Practice to Research: Proposals and Strategy of the French EFFADOL Program.

In the field of cancer pain, therapeutic patient education (TPE) allows patients to develop skills to better manage their pain. In the Lower Normandy region of France, the management of pain is based on networking, thus allowing proximity and accessibility for all concerned. We have thus designed and initiated a broad five-stage research program that includes the following: (1) training for caregivers in TPE; (2) identifying the educational expectations of patients and their relatives with regard to cancer pain; (3) the design of a TPE program; (4) the evaluation of its quality; and (5) the evaluation of its effectiveness by comparative randomization. This article presents this approach and more particularly the research phases (stages 2, 4, 5) for which the objectives, the methodology, and the expected results are justified. Among the key points, particular attention is paid to the evaluation of the educational dimension that provides patients with self-efficacy to participate actively in the management of their pain, their perception of changes in relation to it and its impact. The choice of a specific assessment criterion (subscale 9 of the Brief Pain Inventory) and of the step-wedge design are thus argued. This approach, which is based on a partnership between health care professionals and researchers, aims to demonstrate the benefits provided by TPE to patients in order to enable them to better manage their pain on a daily basis.

A vibrotactile wristband to help older pedestrians make safer street-crossing decisions.

INTRODUCTION: Older pedestrians are overrepresented in fatal accidents. Studies consistently show gap-acceptance difficulties, especially in complex traffic situations such as two-way streets and when vehicles approached rapidly. In this context, the present research was aimed at assessing the effectiveness of a vibrotactile device and study older pedestrian's behavior when wearing the wristband designed to help them make safer street-crossing decisions. METHOD: Twenty younger-old participants (age 60-69), 20 older-old participants (age 70-80) and 17 younger adults (age 20-45) carried out a street-crossing task in a simulated two-way traffic environment with and without a vibrotactile wristband delivering warning messages. RESULTS: The percentage of decisions that led to collisions with approaching cars decreased significantly when participants wore the wristband. Benefits tended to be greater particularly among very old women, with fewer collisions in the far lane and when vehicles approached rapidly when they wore the wristband. But collisions did not fall to zero, and responses that were in accordance with the wristband advice went up to only 51.6% on average, for all participants. The wristband was nevertheless considered useful and easy to use by all participants. Moreover, behavioral intentions to buy and use such a device in the future were greater in both groups of older participants, but not among the younger adults. PRACTICAL APPLICATIONS: This haptic device was able to partly compensate for some age-related gap-acceptance difficulties and reduce street-crossing risks for all users. These findings could be fruitfully applied to the design of devices allowing communication between vehicles, infrastructures, and pedestrians.

[Territorial resources and access to care in the case of chronic pain]. / Ressources territoriales et accès aux soins en cas de douleur chronique.

To respond to the complexity of the management of patients with chronic pain, an adapted and structured biopsychosocial approach is necessary. Created and managed by committed caregivers, regulated and financed by decision-making bodies, chronic pain assessment and treatment centres form part of the patient care pathway.

Searching for information on the World Wide Web with a search engine: a pilot study on cognitive flexibility in younger and older users.

This pilot study investigated the age-related differences in searching for information on the World Wide Web with a search engine. 11 older adults (6 men, 5 women; M age=59 yr., SD=2.76, range=55-65 yr.) and 12 younger adults (2 men, 10 women; M=23.7 yr., SD=1.07, range=22-25 yr.) had to conduct six searches differing in complexity, and for which a search method was or was not induced. The results showed that the younger and older participants provided with an induced search method were less flexible than the others and produced fewer new keywords. Moreover, older participants took longer than the younger adults, especially in the complex searches. The younger participants were flexible in the first request and spontaneously produced new keywords (spontaneous flexibility), whereas the older participants only produced new keywords when confronted by impasses (reactive flexibility). Aging may influence web searches, especially the nature of keywords used.

The use of Tholos software for combining measures of mental workload: toward theoretical and methodological improvements.

Mental workload is a concept central to a range of disciplines (including cognitive psychology and ergonomics) that has given rise to various theoretical and methodological debates. As a result, researchers have used a number of techniques for measuring mental workload. Traditionally, three categories of measurement technique have been recognized: performance measures (e.g., the dual-task paradigm), subjective measures (e.g., rating scales), and physiological measures (e.g., heart, respiration, and blink rates). Each technique has advantages and limitations; however, some limitations may prevent an accurate evaluation of the mental workload. In this article, we focus on the benefits of combining multiple measures of mental workload. However, because combining several techniques is a very complex process, we have developed the Tholos software in an attempt to reduce this complexity. This software package uses measures from each of the three categories: a dual-task paradigm with auditory signals; the National Aeronautics and Space Administration task load index (NASA-TLX) scale and its simplified version, the "raw" task load index (RTLX); and physiological (such as pupil-dilation) measurements with which our software can merge results from the dual-task paradigm. To illustrate the benefits of using Tholos, we describe a puzzle-solving experiment in which we combined multiple measures of mental workload. The results indicate the importance of combining multiple measures to build upon the theoretical and methodological foundations of mental workload.

Stakeholders' influence on the importance of users' and clients' information and constraints during website design.

The present study aims at determining the role of the stakeholder (via a user vs a client spokesperson) on the importance allocated to information and constraints considered by novice and professional web designers. Analysis showed all designers focused mainly on clients' constraints and information even when they dealt with a user spokesperson: they considered clients' constraints as more important than users' constraints. These results are new with regard to those previously obtained in web design, which showed designers considered prescribed constraints (regardless of the stakeholder to which they are related) as unavaoidable, and the vast majority of others as avoidable if required. Research is required to help web designers to ponder users' and clients' constraints and to assess whether the same patterns of results occur in other design domains.

A constraint-satisfaction approach to studying the management of multiple objectives in design problem-solving.

How professional and novice designers manage multiple objectives through constraint satisfaction was studied. An objective is defined as a network of constraints; a constraint is characterized as related to a source (internal or external) and an addressee (e.g., client or user). It has been shown that designers favour objectives related to external constraint (e.g., data from the task) and to the client. Generally, client and external constraints are identical. To study the management of multiple objectives, fifteen web site designers were instructed to design a site according to user's objectives or client's objectives. Our results indicate that the validity status allocated to constraints is more determined by the status of the addressee than by the status of the source, whatever the objective condition that must be satisfied. Possible methodological generalizations are discussed.