Gene-environment pathways to cognitive intelligence and psychotic-like experiences in children.

In children, psychotic-like experiences (PLEs) are related to risk of psychosis, schizophrenia, and other mental disorders. Maladaptive cognitive functioning, influenced by genetic and environmental factors, is hypothesized to mediate the relationship between these factors and childhood PLEs. Using large-scale longitudinal data, we tested the relationships of genetic and environmental factors (such as familial and neighborhood environment) with cognitive intelligence and their relationships with current and future PLEs in children. We leveraged large-scale multimodal data of 6,602 children from the Adolescent Brain and Cognitive Development Study. Linear mixed model and a novel structural equation modeling (SEM) method that allows estimation of both components and factors were used to estimate the joint effects of cognitive phenotypes polygenic scores (PGSs), familial and neighborhood socioeconomic status (SES), and supportive environment on NIH Toolbox cognitive intelligence and PLEs. We adjusted for ethnicity (genetically defined), schizophrenia PGS, and additionally unobserved confounders (using computational confound modeling). Our findings indicate that lower cognitive intelligence and higher PLEs are significantly associated with lower PGSs for cognitive phenotypes, lower familial SES, lower neighborhood SES, and less supportive environments. Specifically, cognitive intelligence mediates the effects of these factors on PLEs, with supportive parenting and positive school environments showing the strongest impact on reducing PLEs. This study underscores the influence of genetic and environmental factors on PLEs through their effects on cognitive intelligence. Our findings have policy implications in that improving school and family environments and promoting local economic development may enhance cognitive and mental health in children.

Childhood is a critical period for brain development. Difficult experiences during this developmental phase may contribute to reduced intelligence and poorer mental health later in life. Genetics and environmental factors also play roles. For example, having family support or a higher family income has been linked to better brain health outcomes for children. Delusions or hallucinations, or other psychotic-like experiences during childhood, are linked with poor mental health later in life. Children who experience psychotic-like episodes between the ages of nine and eleven have a higher risk of developing schizophrenia or related conditions. Environmental circumstances during childhood also appear to play a crucial role in shaping the risk of schizophrenia or related conditions. Park, Lee et al. show that positive parenting and supportive school and neighborhood environments boost child intelligence and mental health. In the experiments, Park, Lee et al. analyzed data on 6,602 children to determine how genetics and environmental factors shaped their intelligence and mental health. The models show that children with higher intelligence have a lower risk of psychosis. Both genetics and supportive environments contribute to higher intelligence. Complex interactions between biology and social factors shape children's intelligence and mental health. Beneficial genetics and coming from a family with more financial resources are helpful. Yet, social environments, such as having parents who use positive child-rearing practices, or having supportive schools or neighborhoods, have protective effects that can offset other disadvantages. Policies that help parents, encourage supportive school environments, and strengthen neighborhoods may boost children's intelligence and mental health later in life.

Generalized Structured Component Analysis Accommodating Convex Components: A Knowledge-Based Multivariate Method with Interpretable Composite Indexes.

Generalized structured component analysis (GSCA) is a multivariate method for examining theory-driven relationships between variables including components. GSCA can provide the deterministic component score for each individual once model parameters are estimated. As the traditional GSCA always standardizes all indicators and components, however, it could not utilize information on the indicators' scale in parameter estimation. Consequently, its component scores could just show the relative standing of each individual for a component, rather than the individual's absolute standing in terms of the original indicators' measurement scales. In the paper, we propose a new version of GSCA, named convex GSCA, which can produce a new type of unstandardized components, termed convex components, which can be intuitively interpreted in terms of the original indicators' scales. We investigate the empirical performance of the proposed method through the analyses of simulated and real data.

A comparative evaluation of factor- and component-based structural equation modelling approaches under (in)correct construct representations.

Structural equation modelling (SEM) has evolved into two domains, factor-based and component-based, dependent on whether constructs are statistically represented as common factors or components. The two SEM domains are conceptually distinct, each assuming their own population models with either of the statistical construct proxies, and statistical SEM approaches should be used for estimating models whose construct representations correspond to what they assume. However, SEM approaches have often been evaluated and compared only under population factor models, providing misleading conclusions about their relative performance. This is partly because population component models and their relationships have not been clearly formulated. Also, it is of fundamental importance to examine how robust SEM approaches can be to potential misrepresentation of constructs because researchers may often lack clear theories to determine whether a factor or component is more representative of a given construct. Addressing these issues, this study begins by clarifying several population component models and their relationships and then provides a comprehensive evaluation of four SEM approaches - the maximum likelihood approach and factor score regression for factor-based SEM as well as generalized structured component analysis (GSCA) and partial least squares path modelling (PLSPM) for component-based SEM - under various experimental conditions. We confirm that the factor-based SEM approaches should be preferred for estimating factor models, whereas the component-based SEM approaches should be chosen for component models. Importantly, the component-based approaches are generally more robust to construct misrepresentation than the factor-based ones. Of the component-based approaches, GSCA should be chosen over PLSPM, regardless of whether or not constructs are misrepresented.

A knowledge-based multivariate statistical method for examining gene-brain-behavioral/cognitive relationships: Imaging genetics generalized structured component analysis.

With advances in neuroimaging and genetics, imaging genetics is a naturally emerging field that combines genetic and neuroimaging data with behavioral or cognitive outcomes to examine genetic influence on altered brain functions associated with behavioral or cognitive variation. We propose a statistical approach, termed imaging genetics generalized structured component analysis (IG-GSCA), which allows researchers to investigate such gene-brain-behavior/cognitive associations, taking into account well-documented biological characteristics (e.g., genetic pathways, gene-environment interactions, etc.) and methodological complexities (e.g., multicollinearity) in imaging genetic studies. We begin by describing the conceptual and technical underpinnings of IG-GSCA. We then apply the approach for investigating how nine depression-related genes and their interactions with an environmental variable (experience of potentially traumatic events) influence the thickness variations of 53 brain regions, which in turn affect depression severity in a sample of Korean participants. Our analysis shows that a dopamine receptor gene and an interaction between a serotonin transporter gene and the environment variable have statistically significant effects on a few brain regions' variations that have statistically significant negative impacts on depression severity. These relationships are largely supported by previous studies. We also conduct a simulation study to safeguard whether IG-GSCA can recover parameters as expected in a similar situation.

An approach to structural equation modeling with both factors and components: Integrated generalized structured component analysis.

In this article, we propose integrated generalized structured component analysis (IGSCA), which is a general statistical approach for analyzing data with both components and factors in the same model, simultaneously. This approach combines generalized structured component analysis (GSCA) and generalized structured component analysis with measurement errors incorporated (GSCAM) in a unified manner and can estimate both factor- and component-model parameters, including component and factor loadings, component and factor path coefficients, and path coefficients connecting factors and components. We conduct 2 simulation studies to investigate the performance of IGSCA under models with both factors and components. The first simulation study assesses how existing approaches for structural equation modeling and IGSCA recover parameters. This study shows that only consistent partial least squares (PLSc) and IGSCA yield unbiased estimates of all parameters, whereas the other approaches always provided biased estimates of several parameters. As such, we conduct a second, extensive simulation study to evaluate the relative performance of the 2 competitors (PLSc and IGSCA), considering a variety of experimental factors (model specification, sample size, the number of indicators per factor/component, and exogenous factor/component correlation). IGSCA exhibits better performance than PLSc under most conditions. We also present a real data application of IGSCA to the study of genes and their influence on depression. Finally, we discuss the implications and limitations of this approach, and recommendations for future research. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Global Least Squares Path Modeling: A Full-Information Alternative to Partial Least Squares Path Modeling.

Partial least squares path modeling has been widely used for component-based structural equation modeling, where constructs are represented by weighted composites or components of observed variables. This approach remains a limited-information method that carries out two separate stages sequentially to estimate parameters (component weights, loadings, and path coefficients), indicating that it has no single optimization criterion for estimating the parameters at once. In general, limited-information methods are known to provide less efficient parameter estimates than full-information ones. To address this enduring issue, we propose a full-information method for partial least squares path modeling, termed global least squares path modeling, where a single least squares criterion is consistently minimized via a simple iterative algorithm to estimate all the parameters simultaneously. We evaluate the relative performance of the proposed method through the analyses of simulated and real data. We also show that from algorithmic perspectives, the proposed method can be seen as a block-wise special case of another full-information method for component-based structural equation modeling-generalized structured component analysis.

Comparison of Bootstrap Confidence Interval Methods for GSCA Using a Monte Carlo Simulation.

Generalized structured component analysis (GSCA) is a theoretically well-founded approach to component-based structural equation modeling (SEM). This approach utilizes the bootstrap method to estimate the confidence intervals of its parameter estimates without recourse to distributional assumptions, such as multivariate normality. It currently provides the bootstrap percentile confidence intervals only. Recently, the potential usefulness of the bias-corrected and accelerated bootstrap (BCa) confidence intervals (CIs) over the percentile method has attracted attention for another component-based SEM approach-partial least squares path modeling. Thus, in this study, we implemented the BCa CI method into GSCA and conducted a rigorous simulation to evaluate the performance of three bootstrap CI methods, including percentile, BCa, and Student's t methods, in terms of coverage and balance. We found that the percentile method produced CIs closer to the desired level of coverage than the other methods, while the BCa method was less prone to imbalance than the other two methods. Study findings and implications are discussed, as well as limitations and directions for future research.

Review of Machine Learning Algorithms for Diagnosing Mental Illness.

OBJECTIVE: Enhanced technology in computer and internet has driven scale and quality of data to be improved in various areas including healthcare sectors. Machine Learning (ML) has played a pivotal role in efficiently analyzing those big data, but a general misunderstanding of ML algorithms still exists in applying them (e.g., ML techniques can settle a problem of small sample size, or deep learning is the ML algorithm). This paper reviewed the research of diagnosing mental illness using ML algorithm and suggests how ML techniques can be employed and worked in practice. METHODS: Researches about mental illness diagnostic using ML techniques were carefully reviewed. Five traditional ML algorithms-Support Vector Machines (SVM), Gradient Boosting Machine (GBM), Random Forest, Naïve Bayes, and K-Nearest Neighborhood (KNN)-frequently used for mental health area researches were systematically organized and summarized. RESULTS: Based on literature review, it turned out that Support Vector Machines (SVM), Gradient Boosting Machine (GBM), Random Forest, Naïve Bayes, and K-Nearest Neighborhood (KNN) were frequently employed in mental health area, but many researchers did not clarify the reason for using their ML algorithm though every ML algorithm has its own advantages. In addition, there were several studies to apply ML algorithms without fully understanding the data characteristics. CONCLUSION: Researchers using ML algorithms should be aware of the properties of their ML algorithms and the limitation of the results they obtained under restricted data conditions. This paper provides useful information of the properties and limitation of each ML algorithm in the practice of mental health.

Out-of-bag Prediction Error: A Cross Validation Index for Generalized Structured Component Analysis.

Cross validation is a useful way of comparing predictive generalizability of theoretically plausible a priori models in structural equation modeling (SEM). A number of overall or local cross validation indices have been proposed for existing factor-based and component-based approaches to SEM, including covariance structure analysis and partial least squares path modeling. However, there is no such cross validation index available for generalized structured component analysis (GSCA) which is another component-based approach. We thus propose a cross validation index for GSCA, called Out-of-bag Prediction Error (OPE), which estimates the expected prediction error of a model over replications of so-called in-bag and out-of-bag samples constructed through the implementation of the bootstrap method. The calculation of this index is well-suited to the estimation procedure of GSCA, which uses the bootstrap method to obtain the standard errors or confidence intervals of parameter estimates. We empirically evaluate the performance of the proposed index through the analyses of both simulated and real data.

Screening Tool for Anxiety Disorders: Development and Validation of the Korean Anxiety Screening Assessment.

OBJECTIVE: This study evaluated the psychometric properties of the Korean Anxiety Screening Assessment (K-ANX) developed for screening anxiety disorders. METHODS: Data from 613 participants were analyzed. The K-ANX was evaluated for reliability using Cronbach's alpha, item-total correlation, and test information curve, and for validity using focus group interviews, factor analysis, correlational analysis, and item characteristics based on item response theory (IRT). The diagnostic sensitivity and specificity of the K-ANX were compared with those of the Beck Anxiety Inventory (BAI) and Generalized Anxiety Disorder 7-item scale (GAD-7). RESULTS: The K-ANX showed excellent internal consistency (α=0.97) and item-total coefficients (0.92-0.97), and a one-factor structure was suggested. All items were highly correlated with the total scores of the BAI, GAD-7, and Penn State Worry Questionnaire. IRT analysis indicated the K-ANX was most informative as a screening tool for anxiety disorders at the range between 0.8 and 1.6 (i.e., top 21.2 to 5.5 percentiles). Higher sensitivity (0.795) and specificity (0.937) for identifying anxiety disorders were observed in the K-ANX compared to the BAI and GAD-7. CONCLUSION: The K-ANX is a reliable and valid measure to screen anxiety disorders in a Korean sample, with greater sensitivity and specificity than current measures of anxiety symptoms.