Comparison of spasmolytic regimen for prevention of radial artery spasm during the distal radial approach: A single-center, randomized study.

Background: The distal radial approach (DRA) for coronary catheterization is increasingly being used worldwide yet the optimal medication regimen to prevent radial artery spasm (RAS), an important factor for the success of the procedure, remains unclear. The aim of this study is to examine the effectiveness of medication for preventing RAS via the DRA. Methods: This was a prospective, comparative randomized study including 400 patients who underwent coronary catheterization via DRA in single center by three experienced DRA operators. Patients were randomized to either nitroglycerin (NTG) injection (N = 200) or NTG plus verapamil (N = 200) to compare the effectiveness and safety of these regimens. Results: There were no differences between the groups in the changes in radial artery diameter at most spastic area (0.34 ± 0.20 in the NTG group, 0.35 ± 0.20 in the NTG plus verapamil group; P = 0.73). There was no difference between the groups in the ratio of patients without arm pain during the procedure (95.0% in the NTG group, 93.5% in the NTG plus verapamil group; P = 0.67). However, there was a greater reduction in diastolic blood pressure in the NTG plus verapamil group (-8.3 ± 7.9 mmHg) than in the NTG group (-6.6 ± 7.6 mmHg) (P = 0.03). Conclusion: Intra-arterial injection of NTG as a single agent is effective and safe in the prevention of RAS during coronary catheterization via the DRA compared with a cocktail regimen of NTG plus verapamil. Clinical trial registration: https://cris.nih.go.kr, identifier KCT0005177.

Effects of Desk Pedaling Work Rate on Concurrent Work Performance among Physically Inactive Adults: A Randomized Experiment.

PURPOSE: Under-desk pedaling devices could help reduce health risks associated with the global decline in work-related energy expenditure. However, the optimal pedaling work rate to facilitate concurrent work performance among physically inactive adults is unclear. We examined the effects of two light-intensity pedaling work rates on physically inactive adults' work performance. METHODS: We recruited equal numbers of older (45-65 yr) versus younger (20-44 yr), male versus female, and overweight/obese (body mass index [BMI], 25-35 kg·m -2 ) versus normal weight (BMI, 18.5-24.9 kg·m -2 ) participants. Using a Graeco-Latin square design, participants ( n = 96) completed a laboratory experiment to evaluate the effects of using an under-desk pedaling device at two seated light-intensity work rates (17 and 25 W), relative to a seated nonpedaling condition on objectively measured typing, reading, logical reasoning, and phone task performance. Ergonomic comfort under each pedaling work rate was also assessed. Equivalence tests were used to compare work performance under the pedaling versus nonpedaling conditions. RESULTS: Treatment fidelity to the 17- and 25-W pedaling work rates exceeded 95%. Mean work performance scores for each pedaling and nonpedaling condition were equivalent under alpha = 0.025. Age, sex, and BMI did not significantly moderate the effect of pedaling on work performance. Participants reported greater ergonomic comfort while completing work tasks at the 17-W relative to the 25-W work rate. CONCLUSIONS: Physically inactive adults obtained similar work performance scores under the 17- and 25-W pedaling and the nonpedaling conditions, suggesting that either pedaling work rate could help reduce health risks of sedentary work time. The 17-W work rate yielded greater ergonomic comfort and may be an appropriate starting point for introducing diverse inactive workers to under-desk pedaling.

Utilizing anthropometric data to improve the usability of desk bikes, and influence of desk bikes on reading and typing performance.

This study investigated the feasibility of using a desk bike in an office setting. Workstation measurements were introduced to accommodate 95% of the general U.S. population in using desk bikes. Reading and typing performances were compared at three different cycling conditions (no cycling, 10 and 25 W). Thirty healthy individuals (15 female and 15 male; Age mean: 23.1, σ: 4.19) were recruited based on 5/50/95th percentile stature. Participants were required to select preferred workstation settings and perform reading and typing tasks while pedaling. According to anthropometric measurements and variability from user preference, recommended adjustable ranges of workstation settings for the general U.S. population were derived. Repeated measures ANOVA showed that pedaling had no significant effect on reading comprehension (p > 0.05), but had significant effect on typing performance (p < 0.001). A preferred level of cycling intensity was determined (mean 17.3 W, σ: 3.69).

Biodegradation of alkylates under less agitated aquifer conditions.

The biodegradability of three alkylates (2,3-dimethylpentane, 2,4-dimethylpentane and 2,2,4-trimethylpentane) under less agitated aquifer conditions was investigated in this study. All three alkylates biodegraded completely under these conditions regardless of the presence or absence of ethanol or benzene, toluene, ethylbenzene, and xylenes (BTEX) in the feed. In the presence of ethanol, alkylates degradation was not inhibited by ethanol. However, alkylates degraded more slowly in the presence of BTEX suggesting competitive inhibition to microbial utilization of alkylates. In the sterile controls, alkylates concentrations remained unchanged throughout the experiments.

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia.

Mutations of fibroblast growth factor receptor 3 (FGFR3) are responsible for achondroplasia (ACH) and related dwarfing conditions in humans. The pathogenesis involves constitutive activation of FGFR3, which inhibits proliferation and differentiation of growth plate chondrocytes. Here we report that activating mutations in FGFR3 increase the stability of the receptor. Our results suggest that the mutations disrupt c-Cbl-mediated ubiquitination that serves as a targeting signal for lysosomal degradation and termination of receptor signaling. The defect allows diversion of actively signaling receptors from lysosomes to a recycling pathway where their survival is prolonged, and, as a result, their signaling capacity is increased. The lysosomal targeting defect is additive to other mechanisms proposed to explain the pathogenesis of ACH.