RESUMO
Schwannoma of cervical sympathetic chain is a rare cause of neck swelling. We report a 73- year-old male presented with anterior neck triangle swelling mimicking a carotid body tumour. Surgical excision was done, and the histopathological examination reported as ancient schwannoma. We would like to discuss the important differential diagnoses and highlight the possibility of an ancient schwannoma of cervical sympathetic chain masquerading as carotid body tumour. Also, to emphasise the importance of imaging for pre-operative planning and counselling.
Assuntos
Tumor do Corpo Carotídeo/diagnóstico , Gânglios Simpáticos , Neoplasias de Cabeça e Pescoço/diagnóstico , Neurilemoma/diagnóstico , Idoso , Diagnóstico Diferencial , Gânglios Simpáticos/cirurgia , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Masculino , Neurilemoma/cirurgiaRESUMO
Two DTPA derivatives (PIP-DTPA and AZEP-DTPA) as potential contrast enhancement agents in MRI are synthesized. The T1 and T2 relaxivities of their corresponding Gd(III) complexes are reported. At clinically relevant field strengths, the relaxivities of the complexes are comparable to that of the contrast agent, Gd(DTPA) which is in clinical use. The serum stability of the (153)Gd-labeled complexes is assessed by measuring the release of (153)Gd from the ligands. The radiolabeled Gd chelates are found to be kinetically stable in human serum for up to at least 14 days without any measurable loss of radioactivity.
Assuntos
Meios de Contraste/química , Compostos Heterocíclicos/química , Ácido Pentético/análogos & derivados , Ácido Pentético/química , Piperidinas/química , Gadolínio/sangue , Gadolínio/química , Gadolínio DTPA/sangue , Gadolínio DTPA/química , Compostos Heterocíclicos/sangue , Imageamento por Ressonância Magnética/métodos , Ressonância Magnética Nuclear Biomolecular , Ácido Pentético/sangue , Piperidinas/sangue , Radioisótopos/sangue , Radioisótopos/químicaRESUMO
1. The metabolism of 7,8-benzoflavone (ANF) was studied in human liver microsomal fractions. Five metabolites were generated and tentatively identified as ANF 5,6-oxide, 5,6-dihydrodiol, 7,8-dihydrodiol, 6-hydroxy ANF, and 7-hydroxy ANF based on UV and mass spectral analysis. 2. The involvement of P4503A in the metabolism of ANF was confirmed by the following observations: (1) correlation of ANF 5,6-oxide formation was noted with testosterone 6 beta-hydroxylation, an indicator of P4503A, in human liver microsomal fractions; (2) metabolism of ANF was inhibited by various selective P4503A enzyme inhibitors; (3) rabbit antibody raised against P4503A4 inhibited the ANF metabolism by > 80%; and (4) microsomal fractions that specifically expressed P4503A4 metabolized ANF to oxidized metabolites. 3. These results indicate that P4503A isoform(s) mainly metabolize ANF to oxidized derivatives in human liver microsomal fractions.