1.
J Org Chem
; 86(17): 12354-12366, 2021 09 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34402303
RESUMO
This article reports diastereoselective cyclization with chiral sulfinamides as nucleophiles in two reaction pathways: (1) intramolecular allylic substitution and (2) sequential aerobic oxidation with aza-Michael addition. These reactions were enabled by synergistic palladium and Brønsted acid catalysis and produced chiral isoindolines with good yields of 55-92% and high diastereoselectivities of 10:1 to >20:1 dr.