1.
Genes (Basel)
; 12(10)2021 09 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34680910
RESUMO
Our understanding of the molecular basis of colorectal neoplasia is derived from Mendelian genetics, with tumor suppressor genes contributing more to the deregulation of growth than oncogenes. In patients with hereditary syndromes, expression of one allele of a key tumor suppressor gene is absent at birth. The loss of the expression of the second allele precipitates tumorigenesis. However, there are multiple ways in which the expression of the second allele of a tumor suppressor gene is lost. Here, we review these ways and their possible effect on phenotype.
Assuntos
Polipose Adenomatosa do Colo/genética , Carcinogênese/genética , Perda de Heterozigosidade , Polipose Adenomatosa do Colo/metabolismo , Polipose Adenomatosa do Colo/patologia , Proteína da Polipose Adenomatosa do Colo/genética , Proteína da Polipose Adenomatosa do Colo/metabolismo , Animais , Humanos
2.
Dis Colon Rectum
; 60(7): e595-e596, 2017 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28594729