RESUMO
The authors study the reactivation of B hepatitis virus in three HIV infected patients, correlating the moment of reactivation of and the CD4 and CD8 lymphocytes. Prior to the B viral reactivation, the three patients were with Ac HBc IgG (+) in serum, assessing that the presence of AC HBc IgG is insufficient to prevent the reactivation and to consider a B hepatitis cured. In two patients, prior to the B virus reactivation, AgHBs was (-) in the serum. It is considered that the predominant hepatocytolysis mechanism is the viral one, in the stage of B virus reactivation in patients with AIDS, the cell immunity mechanism being depressed.
Assuntos
Infecções por HIV/virologia , HIV-1 , Vírus da Hepatite B/crescimento & desenvolvimento , Hepatite B/virologia , Ativação Viral , Biomarcadores/sangue , Relação CD4-CD8 , DNA Viral/sangue , Infecções por HIV/imunologia , Hepatite B/imunologia , Anticorpos Anti-Hepatite B/sangue , Antígenos da Hepatite B/sangue , Vírus da Hepatite B/genética , Vírus da Hepatite B/imunologia , Humanos , Imunoglobulina G/sangue , Masculino , RecidivaRESUMO
The authors present 4 cases of chronic AgHBs positive hepatitis, with reactivations of hepatitis B virus. The reactivations occurred spontaneously, as mentioned in references. The authors appreciate that the cause of B virus reactivation bases upon factors which modify the immune status of the host. Alcohol is one of these factors, not yet mentioned in references as cause of virus B reactivation. Are also presented data about the existence of virus B mutants, in the studied patients, which could play a role in the reactivation of chronic hepatitis B.