1.
Org Lett
; 6(22): 4069-72, 2004 Oct 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15496101
RESUMO
[reaction: see text] Chiral 1-aryl-6-(hydroxymethyl)-2-ketopiperazines can be prepared via an operationally simple, 6-exo epoxide ring-opening cyclization to form the ketopiperazine C6-N1 bond in high yields and with excellent enantiomeric purity.