RESUMO
This case was the subject of a Grand Round Presentation at the Royal Marsden Hospital, Sutton, UK on 8 June 2004. A case of metachronous, bilateral testicular germ-cell tumours (TGCTs) arising in a patient with a family history of this disease was presented. The second primary was managed conservatively. The rationale and outcome of this approach was presented, along with a discussion of the management of early stage TGCTs and the genetics of familial and bilateral disease.
Assuntos
Germinoma/terapia , Segunda Neoplasia Primária/terapia , Neoplasias Testiculares/terapia , Adulto , Terapia Combinada , Germinoma/patologia , Humanos , Masculino , Estadiamento de Neoplasias , Segunda Neoplasia Primária/patologia , Neoplasias Testiculares/patologiaRESUMO
Central nervous system (CNS) presentation of adult T-cell lymphoma/leukaemia is rare, and almost invariably associated with systemic disease. We report an unusual manifestation of adult T-cell lymphoma/leukaemia, with isolated CNS involvement and unusual imaging findings. We also describe objective response to antiviral therapy. To our knowledge, this is the first report of such presentation and response.