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1.
Pharmacy (Basel) ; 12(4)2024 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-39195843

RESUMO

Vaccines have played a significant role in reducing infectious disease burden. However, vaccine hesitancy remains a persistent challenge in public health, including for pharmacists who often interact with patients regarding vaccines. Thus, this study assesses the impact of motivational interviewing (MI) training and the MI-based vaccine hesitancy discussion tools (MOTIVE) on pharmacists' management of vaccine hesitancy. Pharmacists in eight Midwestern pharmacy practices who completed MI and MOTIVE training and engaged with vaccine-hesitant patients participated in this study. The pharmacist participants completed post-encounter surveys identifying the vaccine discussed, the tool utilized, and the outcome of the conversation. Descriptive results from 362 encounters indicated that the primary reasons for hesitancy were safety (39%), care coordination (31.5%), and efficacy (30.4%). Post encounter, 35.4% of patients received vaccines, 26% planned to, 25.1% considered it, and 13.5% were uninterested. The findings highlight the importance of patient-centered communication, such as MI, between patients and pharmacists to identify and address reasons for vaccine hesitancy. Pharmacists, equipped with conversation tools such as the MOTIVE tools, may effectively influence vaccine acceptance. Future research should evaluate the utility of MI and the MOTIVE tools in other settings and regions.

2.
Nurs Clin North Am ; 59(2): 183-188, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38670688

RESUMO

This article explores HIV care for transgender individuals; in particular, the barriers to early diagnosis of HIV, access and engagement in care, and disease complications. The article also examines how Advanced Practice Nurse Practitioners and other health care providers are well-positioned to mitigate these obstacles to wellness.


Assuntos
Infecções por HIV , Pessoas Transgênero , Humanos , Infecções por HIV/enfermagem , Pessoas Transgênero/psicologia , Feminino , Masculino , Acessibilidade aos Serviços de Saúde
3.
Opt Lett ; 49(3): 734-737, 2024 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-38300102

RESUMO

A honeycomb Floquet lattice with helically rotating waveguides and an interface separating two counter-propagating subdomains is analyzed. Two topologically protected localized waves propagate unidirectionally along the interface. Switching can occur when these interface modes reach the edge of the lattice and the light splits into waves traveling in two opposite directions. The incoming mode, traveling along the interface, can be adjusted and routed entirely or partially along either lattice edge with the switching direction based on a suitable mixing of the interface modes.

4.
J Pediatr Pharmacol Ther ; 28(4): 323-328, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37795288

RESUMO

OBJECTIVE: Data evaluating the use of unlicensed cannabidiol (CBD) products for the treatment of -symptoms associated with anxiety and neurodevelopmental disorders in children are limited despite increasing -product availability. The objectives of this study are to quantify the usage of unlicensed CBD products among pediatric patients diagnosed with anxiety and neurodevelopmental disorders and compare the -perceptions of CBD between parents who administer a CBD product to a child and parents who do not. METHODS: A survey containing 31 items was designed after pretesting with pediatric health care professionals. The refined survey was distributed using Qualtrics Panels to a representative sample of US parents of a child 7 to 18 years of age diagnosed with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and/or generalized anxiety disorder (GAD). Responses were analyzed with descriptive -statistics and compared using a χ2 or Mann-Whitney U test. RESULTS: Of the 518 completed surveys, 162 parents (31.3%) reported the administration of an unlicensed CBD product to a child with ADHD, ASD, and/or GAD. The highest prevalence of use was found in the West geographic region and among children diagnosed with GAD or with 2 or more diagnoses (i.e., ADHD, ASD, GAD). Parents who administered CBD products had more positive views of product safety and higher -perceived community support for usage. CONCLUSIONS: Nearly one-third of parents have administered an unlicensed CBD product to a child with ADHD, ASD, and GAD. Health care providers should assess pediatric patients for CBD use and be prepared to engage parents in conversations regarding the safety of these products.

5.
Am J Pharm Educ ; 87(8): 100090, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37597914

RESUMO

OBJECTIVE: The objective of this study was to determine if peer instruction (PI) is a useful active learning pedagogy to increase correct responses to pharmacotherapy concepts throughout didactic education in a Doctor of Pharmacy curriculum. METHODS: Peer instruction was implemented into 3 pharmacy practice courses spanning 3 years of didactic pharmacy education at Cedarville University: Introduction to Self-Care (PHAR 6112) in the first professional year, Respiratory Module (PHAR 6261) in the second professional year, and Special Populations Module (PHAR 7343) in the third professional year. ConcepTests, which are multiple-choice questions written to help students apply previous knowledge to new scenarios, were re-polled based on a PI algorithm after peer discussion. Changes in students paired before and after peer discussion ConcepTest responses were analyzed using a McNemar test and descriptive statistics. RESULTS: A total of 52 first-year students, 43 second-year students, and 49 third-year students participated in each respective course. Across all courses, an increase in the percentage of correct responses to ConceptTests after peer discussion was observed from the first polling (51.2%) to the second polling (90.4%). This increase in the percentage of correct responses was observed across all years of the curriculum, with greater increases in cohorts with previous participation in PI-based sessions. CONCLUSION: The use of PI fostered improvement in the percentage of correct responses to ConcepTests focused on pharmacotherapy concepts throughout the first 3 years of didactic education. This pedagogy may be an effective and useful active learning strategy in pharmacy education that does not require significant classroom infrastructure changes.


Assuntos
Educação em Farmácia , Assistência Farmacêutica , Farmácia , Humanos , Currículo , Aprendizagem Baseada em Problemas
6.
Am J Health Syst Pharm ; 80(2): 68-74, 2023 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-36094556

RESUMO

PURPOSE: To describe the development and implementation of an electronic pharmacy scoring tool (PST) to prioritize patients requiring clinical pharmacy intervention and assist in workload management in a freestanding pediatric hospital using quality improvement methodology. SUMMARY: The department of pharmacy at Nationwide Children's Hospital developed a pediatric-specific PST within the electronic medical record to aid in patient prioritization and ensuring proficient daily workflow and qualifying workload for clinical pharmacists. The PST identifies patients for monitoring of high-risk medications, complex medication regimens, or abnormal laboratory values related to medication management. Application of the scoring tool ensures each patient is reviewed by clinical pharmacy staff each day, with initial efforts focused on patients with significant clinical pharmacy needs. This tool reduces the need for time-intensive manual chart review for identification of patients whose medication use and/or laboratory values afford greater opportunity for pharmacist intervention. Additionally, clinical pharmacist productivity metrics and workloads are considered, with the qualifying of patient care activities and quantification of time spent on patient review. CONCLUSION: A PST enhances pediatric patient prioritization for clinical pharmacists by identifying patients most likely to require intervention in real time. The scoring tool enables future assessment of clinical pharmacists' workload assignments and better quantifies time spent on patient care activities.


Assuntos
Serviço de Farmácia Hospitalar , Farmácia , Humanos , Criança , Farmacêuticos , Fluxo de Trabalho , Eletrônica
9.
J Interv Cardiol ; 2022: 1098429, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35685430

RESUMO

Aim: In this randomized pilot trial, we aimed to assess the anti-inflammatory effect of preprocedural colchicine on coronary microvascular physiology measurements before and after PCI. Methods: Patients undergoing PCI for stable angina (SA) or non-ST-elevation myocardial infarction (NSTEMI) were randomized to oral colchicine or placebo, 6- to 24-hours before the procedure. Strict prespecified inclusion/exclusion criteria were set to ensure all patients were given the study medication, had a PCI, and had pre- and post-PCI culprit vessel invasive coronary physiology measurements. Fractional flow reserve (FFR), Index of Microvascular Resistance (IMR), Coronary Flow Reserve (CFR), and Resistive Reserve Ratio (RRR) were measured immediately before and after PCI. CMVD was defined as any one of post-PCI IMR >32 or CFR <2 or RRR <2. High-sensitive-(hs)-troponin-I, hsCRP, and leucocyte count were measured before and 24 hours after PCI. Results: A total of 50 patients were randomized and met the strict prespecified inclusion/exclusion criteria: 24-colchicine and 26-placebo. Pre-PCI coronary physiology measurements, hs-troponin-I, and hsCRP were similar between groups. Although numerically lower in patients given colchicine, the proportion of patients who developed CMVD was not significantly different between groups (colchicine: 10 (42%) vs placebo: 16 (62%), p=0.16). Colchicine patients had higher post-PCI CFR and RRR vs placebo (respectively: 3.25 vs 2.00, p=0.03 & 4.25 vs 2.75, p < 0.01). Neutrophil count was lower after PCI in the colchicine arm (p=0.02), and hsCRP post-PCI remained low in both treatment arms (1.0 mg/L vs 1.7 mg/L, p=0.97). Patients randomized to colchicine had significantly less PCI-related absolute hs-troponin-I change (46 ng/L vs 152 ng/L, p=0.01). Conclusion: In this pilot randomized substudy, colchicine given 6 to 24 hours before PCI did not statistically impact the post-PCI CMVD definition used in this study, yet it did improve post-PCI RRR and CFR measurements, with less procedure-related troponin release and less inflammation.


Assuntos
Reserva Fracionada de Fluxo Miocárdico , Intervenção Coronária Percutânea , Proteína C-Reativa , Colchicina/farmacologia , Colchicina/uso terapêutico , Angiografia Coronária , Humanos , Microcirculação , Resultado do Tratamento , Troponina I , Resistência Vascular
10.
Nat Biotechnol ; 40(6): 829-831, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35705703
12.
Vaccine ; 40(12): 1846-1854, 2022 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-35153096

RESUMO

BACKGROUND AND OBJECTIVE: Vaccine coverage have been less than desired in young children in part due to parental vaccine hesitancy. Addressing health beliefs through patient-centered communication approaches such as motivational interviewing (MI) may improve vaccine confidence. Thus, the objective of this study was to determine the difference in paediatric vaccination coverage rates based on the Advisory Committee on Immunization Practices (ACIP) and Centers for Disease Control and Prevention (CDC) recommended schedule in children 0-6 years of age after an educational intervention for providers and integration of an MI-based communication tool, MOTIVE (MOtivational Interviewing Tool to Improve Vaccine AcceptancE). METHODS: Paediatric and family practice providers in a federally qualified health center in the United States completed an educational intervention regarding vaccine hesitancy and use of the MOTIVE tool. Providers then implemented the MOTIVE tool to address common health beliefs using strong, presumptive vaccine recommendations and an MI framework during encounters with patients 0-6 years of age. Data were collected from 1-year pre-educational intervention (July 2018-June 2019, N = 2504) and post-intervention (July 2019-March 2020, N = 1954) to examine differences in vaccination coverage rates and documented vaccine refusals. RESULTS: Use of the MOTIVE tool was associated with a statistically significant increase in IIV vaccination coverage rate in children 6 months to 6 years of age (32.4% versus 43.9%, p < 0.01). A significantly increased Hib vaccination coverage rate was observed in children 0-18 months of age. Patients with commercial insurance also had significantly higher vaccination coverage rates for the DTaP, IPV, and VAR vaccines during the intervention period. Use of the MOTIVE tool was associated with a decrease in documented vaccine refusals per 100 patients in children 0-6 years of age (31.5 versus 17.6, p < 0.01). CONCLUSION: Use of an MI-based communication tool may decrease vaccine refusals and improve childhood vaccination coverage rates, particularly for IIV. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT03934008, https://clinicaltrials.gov/ct2/show/NCT03934008, deidentified individual participant data will not be made available.


Assuntos
Entrevista Motivacional , Vacinas , Criança , Pré-Escolar , Humanos , Esquemas de Imunização , Lactente , Motivação , Estados Unidos , Vacinação , Cobertura Vacinal
13.
Res Social Adm Pharm ; 18(7): 3199-3203, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-34400110

RESUMO

Opioid use disorder (OUD) in women of child-bearing potential is problematic in the United States. This has resulted in increasing risk for adverse maternal outcomes, neonatal abstinence syndrome, fetal and neonatal harm, prolonged hospitalizations, and increased health care costs. Pharmacists in all practice settings have opportunities to provide preconception and pregnancy care to prevent and manage OUD. Given pharmacists' scope of practice and expertise, key roles include assessing patients for OUD; mitigating exposure; educating patients regarding potential infant effects; recommending contraceptive methods and counseling on proper use; ensuring safe breastfeeding with concurrent medications; and linking patients to needed services. Through patient counseling, medication management, and harm reduction interventions, pharmacists can work to combat this public health crisis. To encourage increased uptake of pharmacists into these roles, more needs to be done to reimburse pharmacists for these important services and quantify their impact on patient and population health outcomes.


Assuntos
Transtornos Relacionados ao Uso de Opioides , Farmacêuticos , Analgésicos Opioides/uso terapêutico , Anticoncepção , Feminino , Redução do Dano , Humanos , Lactente , Recém-Nascido , Transtornos Relacionados ao Uso de Opioides/tratamento farmacológico , Gravidez , Saúde Pública , Estados Unidos
14.
Emerg Med J ; 39(9): 701-707, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34937708

RESUMO

BACKGROUND: Access to individual percutaneous coronary intervention (PCI) centres has traditionally been determined by historical referral patterns along arbitrarily defined geographic boundaries. We set out to produce predictive models of ST-elevation myocardial infarction (STEMI) demand and time-efficient access to PCI centres. METHODS: Travel times from random addresses to PCI centres in Melbourne, Australia, were estimated using Google map application programming interface (API). Departures at 08:15 and 17:15 were compared with 23:00 to determine the effect of peak hour traffic congestion. Real-world ambulance travel times were compared with estimated travel times using Google map developer software. STEMI incidence per postcode was estimated by merging STEMI incidence per age group data with age group per postcode census data. PCI centre network configuration changes were assessed for their effect on hospital STEMI loading, catchment size, travel times and the number of STEMI cases within 30 min of a PCI centre. RESULTS: Nearly 10% of STEMI cases travelled more than 30 min to a PCI centre, increasing to 20% by modelling the removal of large outer metropolitan PCI centres (p<0.05). A model of 7 PCI centres compared favourably to the current existing network of 11 PCI centres (p=0.18 (afternoon), p=0.5 (morning and night)). The intraclass correlation between estimated travel times and ambulance travel times was 0.82, p<0.001. CONCLUSION: This paper provides a framework to integrate prehospital environmental variables, existing or altered healthcare resources and health statistics to objectively model STEMI demand and consequent access to PCI. Our methodology can be modified to incorporate other inputs to compute optimum healthcare efficiencies.


Assuntos
Intervenção Coronária Percutânea , Infarto do Miocárdio com Supradesnível do Segmento ST , Austrália , Humanos , Estudo de Prova de Conceito , Infarto do Miocárdio com Supradesnível do Segmento ST/terapia , Fatores de Tempo , Resultado do Tratamento
15.
Cardiovasc Revasc Med ; 39: 84-89, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-34686461

RESUMO

BACKGROUND: High levels of inflammation pre- and post-percutaneous coronary intervention (PCI) are associated with worse outcomes. Recent trials have suggested a benefit from treating inflammation with colchicine in coronary artery disease. In this randomised pilot COPE-PCI sub-study, we aimed to determine if administration of colchicine pre-PCI, would attenuate the inflammatory effect of PCI. METHODS: PCI patients were randomised to colchicine or placebo, 6 to 24-hours pre-procedure. Study blood samples were taken immediately pre-PCI, and 24-hours post-procedure. Samples were tested for a broad array of inflammatory biomarkers including high-sensitive(hs)-CRP, leucocyte counts, and hs-troponin-. Periprocedural Myocardial Injury (PM-Injury) was defined as per the ESC Third Universal Definitions of Myocardial Infarction. RESULTS: Thirty-six were randomised to colchicine and 39 to placebo. Treatment groups were similar for baseline variables. The median time from drug administration to pre-PCI blood sampling was 18-hours. Overall inflammation was low across the patient population, pre- & post-PCI hsCRP was <1.4 mg/L. Colchicine patients had numerically lower levels of pre-PCI cytokines: IL-1ß (p = 0.01), IL-6 (p = 0.02), IL-10 (p = 0.01), IFNγ (p = 0.01), TNFα (p = 0.02) and WBC-count (p = 0.04). Post-PCI (38-hours post-drug) measures of inflammation were similar between treatment arms. Absolute troponin change (post-PCI - pre-PCI levels) was less in colchicine patients (p = 0.02). CONCLUSION: The reduction in PCI-related myocardial injury that resulted from colchicine given on median 18 h pre-PCI, was associated with numerically lower levels of inflammation pre-PCI but no difference one day post-PCI in the colchicine vs placebo groups. CLINICAL TRIAL REGISTRATION: The trial was publicly registered at www.anzctr.org.au, Trial ID: ACTRN12615000485538.


Assuntos
Traumatismos Cardíacos , Intervenção Coronária Percutânea , Biomarcadores , Proteína C-Reativa , Colchicina/efeitos adversos , Citocinas , Traumatismos Cardíacos/etiologia , Humanos , Inflamação/diagnóstico , Inflamação/etiologia , Inflamação/prevenção & controle , Intervenção Coronária Percutânea/efeitos adversos , Intervenção Coronária Percutânea/métodos , Projetos Piloto , Troponina
16.
Phys Rev Lett ; 127(10): 104101, 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34533341

RESUMO

Rogue waves are abnormally large waves which appear unexpectedly and have attracted considerable attention, particularly in recent years. The one space, one time (1+1) nonlinear Schrödinger equation is often used to model rogue waves; it is an envelope description of plane waves and admits the so-called Pergerine and Kuznetov-Ma soliton solutions. However, in deep water waves and certain electromagnetic systems where there are two significant transverse dimensions, the 2+1 hyperbolic nonlinear Schrödinger equation is the appropriate wave envelope description. Here we show that these rogue wave solutions suffer from strong transverse instability at long and short frequencies. Moreover, the stability of the Peregrine soliton is found to coincide with that of the background plane wave. These results indicate that, when applicable, transverse dimensions must be taken into account when investigating rogue wave pheneomena.

17.
Macromolecules ; 54(10): 4507-4516, 2021 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-34483366

RESUMO

Photoinduced organocatalyzed atom transfer radical polymerization (O-ATRP) is a controlled radical polymerization methodology catalyzed by organic photoredox catalysts (PCs). In an efficient O-ATRP system, good control over molecular weight with an initiator efficiency (I* = M n,theo/M n,exp × 100%) near unity is achieved, and the synthesized polymers possess a low dispersity (D). N,N-Diaryl dihydrophenazine catalysts typically produce polymers with low dispersity (D < 1.3) but with less than unity molecular weight control (I* ~ 60-80%). This work explores the termination reactions that lead to decreased control over polymer molecular weight and identifies a reaction leading to radical addition to the phenazine core. This reaction can occur with radicals generated through reduction of the ATRP initiator or the polymer chain end. In addition to causing a decrease in I*, this reactivity modifies the properties of the PC, ultimately impacting polymerization control in O-ATRP. With this insight in mind, a new family of core-substituted N,N-diaryl dihydrophenazines is synthesized from commercially available ATRP initiators and employed in O-ATRP. These new core-substituted PCs improve both I* and D in the O-ATRP of MMA, while minimizing undesired side reactions during the polymerization. Further, the ability of one core-substituted PC to operate at low catalyst loadings is demonstrated, with minimal loss of polymerization control down to 100 ppm (weight average molecular weight [M w] = 10.8 kDa, D = 1.17, I* = 104% vs M w = 8.26, D = 1.10, I* = 107% at 1000 ppm) and signs of a controlled polymerization down to 10 ppm of the catalyst (M w = 12.1 kDa, D = 1.36, I* = 107%).

18.
J Pediatr Pharmacol Ther ; 26(6): 556-564, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34421404

RESUMO

Sudden unexpected death in epilepsy (SUDEP) is a serious and devastating, yet poorly understood outcome in epilepsy. This review discusses the current knowledge and understanding of SUDEP in children and adolescents. Established risk factors for SUDEP include history of generalized tonic-clonic seizures and nocturnal seizures. Other proposed risk factors include the use of multiple antiseizure medications and poor medication adherence. Possible prevention strategies for SUDEP include improved medication adherence, surgical interventions, nighttime safety, seizure detection devices, and diet. Pediatric providers have a great opportunity to educate families about SUDEP, assess medication adherence, and provide families with tools to improve medication adherence and learn about SUDEP in children and adolescents with epilepsy. Future research in SUDEP aims to further understand the etiology and risk factors of SUDEP, while developing more intervention strategies to prevent SUDEP.

19.
Phys Rev E ; 103(4-1): 042214, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34005978

RESUMO

The Peierls-Nabarro barrier is a discrete effect that frequently occurs in discrete nonlinear systems. A signature of the barrier is the slowing and eventual stopping of discrete solitary waves. This work examines intense electromagnetic waves propagating through a periodic honeycomb lattice of helically driven waveguides, which serves as a paradigmatic Floquet topological insulator. Here it is shown that discrete topologically protected edge modes do not suffer from the typical slowdown associated with the Peierls-Nabarro barrier. Instead, as a result of their topological nature, the modes always move forward and redistribute their energy: a narrow (discrete) mode transforms into a wide effectively continuous mode. On the other hand, a discrete edge mode that is not topologically protected does eventually slow down and stop propagating. Topological modes that are initially narrow naturally tend to wide envelope states that are described by a generalized nonlinear Schrödinger equation. These results provide insight into the nature of nonlinear topological insulators and their application.

20.
Circ Cardiovasc Interv ; 14(5): e009992, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-34003667

RESUMO

BACKGROUND: Periprocedural myocardial infarction and injury (PM-injury) are the most common complications of percutaneous coronary intervention (PCI) and are associated with future adverse cardiac events. Inflammation plays a pivotal role in the development of PM-injury. In this randomized pilot trial, we assessed the effect of an anti-inflammatory medication colchicine on periprocedural myocardial injury. METHODS: Patients undergoing PCI for stable angina or non­ST-segment­elevation myocardial infarction were randomized to oral colchicine (1 mg followed by 0.5 mg 1 hour later) or placebo, 6 to 24 hours preprocedure. Blood samples were taken immediately pre- and 24-hours post-PCI. The primary outcome, periprocedural myocardial infarction, was defined by an increase in post-PCI troponin >5×99th% upper reference limit when the pre-PCI troponin was normal, or >20% increase in post-PCI troponin when the pre-PCI troponin was raised, including supporting evidence of new myocardial ischemia. Major PM-injury was defined as per periprocedural myocardial infarction without supporting evidence of new myocardial ischemia. Minor PM-injury was defined by post-PCI troponin increase >99th% upper reference limit but ≤5×99th% upper reference limit. RESULTS: A total of 196 patients met inclusion criteria and were randomized. One hundred twenty-one patients were excluded (no PCI, unstable troponin before PCI, or poor-quality measurements) leaving a study population of 75 patients. Thirty-six patients were randomized to colchicine and 39 to placebo preprocedure. Forty-four presented with non­ST-segment­elevation myocardial infarction and 31 with stable angina. High-sensitive (hs) troponin-I pre-PCI was similar between treatment groups (colchicine: 79 ng/L [4­1336] versus placebo: 35 [5­448], P=0.42). Absolute change in hs-troponin-I (calculated as 24-hour post-PCI minus pre-PCI measurements) was significantly lower in the colchicine group: 59 (1­221) versus placebo: 166 (53­530), P=0.02. No patients developed periprocedural myocardial infarction in either group. Significantly fewer patients developed major PM-injury: 11 (31%) versus 21 (54%), P=0.04 or minor PM-injury: 21 (58%) versus 33 (85%), P=0.01, if given colchicine pre-PCI. CONCLUSIONS: In this randomized pilot trial, colchicine given 6 to 24 hours pre-PCI reduces periprocedural myocardial injury.


Assuntos
Infarto do Miocárdio , Intervenção Coronária Percutânea , Colchicina/efeitos adversos , Humanos , Infarto do Miocárdio/prevenção & controle , Intervenção Coronária Percutânea/efeitos adversos , Projetos Piloto , Resultado do Tratamento , Troponina I
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