RESUMO
Smoking and occupational exposure to noise are factors with independent predisposition to sensorineural hearing loss. This is a sinergistic and additive effect. Nevertheless, we have observed that withdrawal of smoking stops the progression on hearing loss in occupational groups with an acoustic exposition lesser than 80 dB SPL. Actually, there is not an unique ethiologic hypothesis.
Assuntos
Perda Auditiva Provocada por Ruído/diagnóstico , Nicotina/efeitos adversos , Doenças Profissionais/diagnóstico , Fumar/efeitos adversos , Síndrome de Abstinência a Substâncias/etiologia , Adulto , Audiometria de Tons Puros , Perda Auditiva Provocada por Ruído/epidemiologia , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/epidemiologia , Humanos , Masculino , Doenças Profissionais/epidemiologia , Índice de Gravidade de Doença , Fumar/epidemiologia , Síndrome de Abstinência a Substâncias/epidemiologiaRESUMO
INTRODUCTION: To evaluate the therapeutic response and the rheologic and immunological characteristics in subjects bearing of rapidly progressive sensorineural hearing loss (RPSHL). PATIENTS AND METHODS: A comparative prospective study on three groups of damaged ears treated with piracetam (n=29), corticosteroids (n=32) and plabcebo (n=25). Hearing loss and recovery level, whole blood filterability (WBF) and a Western-blot (WB) to anticochlear antibodies were evaluated. RESULTS: Recovery average was 20,8 +/- 55,9% in the first group, with progressive of deafness in the rest (p<0,01). WB did not show differences among groups. The higher WBF at the end of therapy was detected on group 1 (20,36 +/- 2,54 Vs 18,42 +/- 3,42 microl/seg on group 3; p<0,05). Moreover, it impaired only on those treated with piracetam, with statistically significative differences over the other two groups. CONCLUSIONS: We detected alterations on WBF in patients with RPSHL that justify the use of rheoactive measures as a pathophysiological therapy.