RESUMO
Covering 2015. Previous review: Nat. Prod. Rep., 2018, 35, 1294-1329This review covers the isolation and structure determination of triterpenoids reported during 2015 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 320 references are cited.
Assuntos
Triterpenos/química , Cristalografia por Raios X , Fungos/química , Estrutura Molecular , Plantas/química , Triterpenos/farmacologiaRESUMO
Covering 2014. Previous review: Nat. Prod. Rep., 2017, 34, 90-122 This review covers the isolation and structure determination of triterpenoids reported during 2014 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 374 references are cited.
Assuntos
Triterpenos/química , Estrutura Molecular , Ácido Oleanólico/análogos & derivados , Ácido Oleanólico/química , Saponinas/química , Esqualeno/química , DamaranosRESUMO
Covering: 2013. Previous review: Nat. Prod. Rep., 2015, 29, 1028-1065This review covers the isolation and structure determination of triterpenoids reported during 2013 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 350 references are cited.
Assuntos
Triterpenos , Estrutura MolecularRESUMO
This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, isomalabaricanes and saponins; 348 references are cited.
Assuntos
Produtos Biológicos , Triterpenos , Estrutura MolecularRESUMO
Two new aromadendrane sesquiterpenoids (1ß,4ß,5ß,6α,7α,11S)-aromadendr-9-en-13,14-dioic acid (1) and (1ß,4ß,5ß,6α,7α,11S)-13-oxoaromadendr-9-en-14-oic acid (2) have been isolated from the stem bark of Alafia multiflora along with ß-sitosterol and ß-sitosterol glucoside. Their structures were established on the basis of spectroscopic analyses, including 1D and 2D NMR experiments (1H-1H COSY, NOESY, HSQC, HMBC). Compound 1 showed a weak growth inhibitory activity against the murine melanoma line B16F10 MTT.
Assuntos
Apocynaceae/química , Sesquiterpenos/isolamento & purificação , Animais , Linhagem Celular Tumoral , Espectroscopia de Ressonância Magnética , Melanoma Experimental/tratamento farmacológico , Camundongos , Casca de Planta/química , Caules de Planta/química , Sesquiterpenos/química , Sesquiterpenos/farmacologia , Sesquiterpenos de GuaianoRESUMO
This review covers the isolation and structure determination of triterpenoids including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, onoceranes and saponins; 308 references are cited.
Assuntos
Produtos Biológicos , Triterpenos , Produtos Biológicos/química , Produtos Biológicos/isolamento & purificação , Estrutura Molecular , Triterpenos/química , Triterpenos/isolamento & purificaçãoRESUMO
This review covers the isolation and structure determination of triterpenoids, including squalene derivatives, protostanes, lanostanes, holostanes, cycloartanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes and saponins; 305 references are cited.
Assuntos
Produtos Biológicos , Triterpenos , Produtos Biológicos/química , Produtos Biológicos/isolamento & purificação , Estrutura Molecular , Triterpenos/química , Triterpenos/isolamento & purificaçãoRESUMO
This review covers the isolation and structure determination of triterpenoids, including squalene derivatives, protostanes, lanostanes, holostanes, cycloartanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes and saponins; 278 references are cited.
Assuntos
Triterpenos , Estrutura MolecularRESUMO
Friedolanostanes, (22Z,24E)-3ß-acetoxy-9α-hydroxy-17,14-friedolanosta-14,22,24-trien-26-oic acid, (22Z,24E)-3ß,9α-dihydroxy-17,14-friedolanosta-14,22,24-trien-26-oic acid, (22Z,24E)-9α-hydroxy-3-oxo-17,14-friedolanosta-14,22,24-trien-26-oic acid, a friedocycloartane, (22Z,24E)-3α-hydroxy-17,13-friedocycloarta-12,22,24-trien-26-oic acid, and a benzophenone, benthaphenone, together with known compounds (22Z,24E)-3α,9α-dihydroxy-17,13-friedolanosta-12,22,24-trien-26-oic acid, methyl (24E)-3α,23-dihydroxy-17,14-friedolanosta-8,14,24-trien-26-oate, glutinol, lupeol, and stigmasterol, were isolated from leaves and bark of Garcinia benthami. Their structures were elucidated using spectroscopic techniques, mainly 1-D and 2-D NMR spectroscopy, and chemical correlations.
Assuntos
Benzofenonas/isolamento & purificação , Garcinia/química , Lanosterol/análogos & derivados , Lanosterol/isolamento & purificação , Triterpenos/isolamento & purificação , Benzofenonas/química , Lanosterol/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Casca de Planta/química , Folhas de Planta/química , Estereoisomerismo , Triterpenos/química , Triterpenos/farmacologia , VietnãRESUMO
This review covers the isolation and structure determination of triterpenoids including squalene derivatives, protostanes, lanostanes, holostanes, cycloartanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, lupanes, oleananes, friedelanes, ursanes, hopanes, isomalabaricanes and saponins; 574 references are cited.
Assuntos
Plantas Medicinais/química , Triterpenos , Estrutura Molecular , Relação Estrutura-Atividade , Triterpenos/química , Triterpenos/classificação , Triterpenos/isolamento & purificação , Triterpenos/farmacologiaRESUMO
Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.
Assuntos
Antimaláricos/isolamento & purificação , Antimaláricos/farmacologia , Cyperaceae/química , Plantas Medicinais/química , Sesquiterpenos/isolamento & purificação , Sesquiterpenos/farmacologia , Antimaláricos/química , Cloroquina/farmacologia , Resistência a Medicamentos/efeitos dos fármacos , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Raízes de Plantas/química , Plasmodium falciparum/efeitos dos fármacos , Sesquiterpenos/química , EstereoisomerismoRESUMO
This review covers the isolation and structure determination of triterpenoids including squalene derivatives, protostanes, lanostanes, holostanes, cycloartanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, isomalabaricanes and saponins. The literature from January 2005 to December 2006 is reviewed and 478 references are cited.
Assuntos
Plantas Medicinais/química , Triterpenos , Estrutura Molecular , Relação Estrutura-Atividade , Triterpenos/química , Triterpenos/classificação , Triterpenos/farmacologiaRESUMO
A new rearranged nor-secoiridoid, anthocleistenolide ( 1), along with the known 1-hydroxy-3,7-dimethoxyxanthone ( 2), 1-hydroxy-3,7,8-trimethoxyxanthone ( 3), 7 alpha-hydroxysitosterol ( 4) and sitosterol 3- O-beta- D-glucopyranoside ( 5), were isolated from the stem back of Anthocleista vogelii. Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1 - 3 and 5 were evaluated for their antibacterial and antifungal activities. Relatively low anti-staphylococcal (MIC = 200 microg/mL against Staphylococcus aureus) and anti-enterococcal (MIC = 100 microg/mL against Enterococcus faecalis) activities were observed for 1, while compounds 2 and 3 were active against Candida parapsilosis (MIC = 200 microg/mL for 2 and 25 microg/mL for 3). Compound 5 was inactive against all the bacterial and fungal species used.
Assuntos
Anti-Infecciosos/farmacologia , Gentianaceae , Iridoides/farmacologia , Fitoterapia , Extratos Vegetais/farmacologia , Anti-Infecciosos/administração & dosagem , Anti-Infecciosos/uso terapêutico , Candida/efeitos dos fármacos , Enterococcus faecalis/efeitos dos fármacos , Humanos , Iridoides/administração & dosagem , Iridoides/química , Iridoides/uso terapêutico , Testes de Sensibilidade Microbiana , Extratos Vegetais/administração & dosagem , Extratos Vegetais/química , Extratos Vegetais/uso terapêutico , Caules de Planta , Staphylococcus aureus/efeitos dos fármacosRESUMO
This review covers the isolation and structure determination of triterpenoids including squalene derivatives, lanostanes, cycloartanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, uranes, hopanes, isomalabaricanes and saponins. The literature from January to December 2004 is reviewed and 243 references are cited.
Assuntos
Plantas Medicinais/química , Triterpenos , Estrutura Molecular , Relação Estrutura-Atividade , Triterpenos/química , Triterpenos/classificação , Triterpenos/farmacologiaRESUMO
A new compound containing a unique terpenoid-quinone skeleton, pycnanthuquinone C (1) along with the known sargachromenol (2), prunetin (3), biochanin A (4), calopiptin (5), (12 S,13 S)-12,13-dihydroxylabda-8(17),14-dien-18-oic acid (6), (12 R,13 S)-12,13-dihydroxylabda-8(17),14-dien-18-oic acid (7), and sitosterol 3- O-beta- D-glucopyranoside (8), were isolated from the stem bark of Pycnanthus angolensis. Their structures were elucidated by spectroscopic means and comparison with published data. The antifungal activity of compounds 1, 2 and 3 was evaluated. Compound 1 was active against Trichophyton soudanense. Compound 2 was active against Trichophyton mentagrophytes while compound 3 was active against Microsporum audouinii and Trichophyton mentagrophytes.
Assuntos
Antifúngicos/isolamento & purificação , Myristicaceae/química , Quinonas/isolamento & purificação , Terpenos/isolamento & purificação , Antifúngicos/química , Antifúngicos/farmacologia , Microsporum/efeitos dos fármacos , Ressonância Magnética Nuclear Biomolecular , Casca de Planta/química , Quinonas/química , Quinonas/farmacologia , Terpenos/química , Terpenos/farmacologia , Trichophyton/efeitos dos fármacosRESUMO
A xanthone derivative, named gaboxanthone (1), has been isolated from the seed shells of Symphonia globulifera, together with known compounds, symphonin (2), globuliferin (3), guttiferone A (4), sistosterol, oleanolic acid and methyl citrate. The structure of the compound was assigned as 5,10-dihydroxy-8,9-dimethoxy-2,2-dimethyl-12-(3-methylbut-2-enyl) pyrano [3,2-b]xanthen-6(2H)-one, by means of spectroscopic analysis. The anti-plasmodial and antioxidant activities of the phenolic compounds were evaluated, respectively, in culture against W2 strain of Plasmodium falciparum and using the free radical scavenging activity of the DPPH radical, respectively. Compounds 1-4 were found to be active against the Plasmodium parasites (IC(50) of 3.53, 1.29, 3.86 and 3.17 microM, respectively). Guttiferone A (4) showed a potent free radical scavenging activity compared to the well-known antioxidant caffeic acid.
Assuntos
Antimaláricos/farmacologia , Antioxidantes/farmacologia , Clusiaceae/química , Xantonas/farmacologia , Animais , Antimaláricos/química , Antimaláricos/isolamento & purificação , Antioxidantes/química , Antioxidantes/isolamento & purificação , Clusiaceae/embriologia , Ácido Oleanólico/química , Ácido Oleanólico/isolamento & purificação , Plasmodium falciparum/efeitos dos fármacos , Sementes/química , Xantonas/química , Xantonas/isolamento & purificaçãoRESUMO
Microbial transformation of the sesquiterpenoid (-)-maalioxide by the fungus Mucor plumbeus gave three metabolites, 9beta-hydroxymaalioxide, 1beta-hydroxymaalioxide and 7beta-hydroxymaalioxide. 9beta-hydroxymaalioxide and its structure was established on the basis of its spectroscopic properties and chemical reactions.
Assuntos
Mucor/metabolismo , Sesquiterpenos/metabolismo , Biotransformação , Cristalografia por Raios X , Espectroscopia de Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética/normas , Modelos Moleculares , Conformação Molecular , Mucor/química , Padrões de Referência , Sesquiterpenos/química , Especificidade da Espécie , EstereoisomerismoRESUMO
A new benzophenanthridine alkaloid, 6-[2'-ethoxy-2'-(2'',4'',5''-trimethoxyphenyl)] ethyl-7,8-dimethoxy-5-methyl-2,3-methylenedioxy-5,6-dihydrobenzo[c]phenanthridine named buesgeniine (1), as well as the known decarine, were isolated from the extract of the stem bark of Zanthoxylum buesgenii. In addition, three known lignans, sesamine, matairesinol dimethylether, and methylpluviatilol, were also identified. The structure of 1 was elucidated using spectroscopic methods.
Assuntos
Alcaloides/química , Alcaloides/isolamento & purificação , Fenantridinas/química , Zanthoxylum/química , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Casca de Planta/químicaRESUMO
A xanthone derivative, 3,6,7-trihydroxy-1-methoxyxanthone has been isolated from the stem bark of Allanblackia monticola together with other known compounds, 2,6-dihydroxy-1-methoxyxanthone, allanxanthone A, epicathechin and oleanolic acid acetate. The structure of the new compound was elucidated by spectroscopic methods.