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1.
J Clin Exp Neuropsychol ; 45(6): 537-552, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38054660

RESUMO

OBJECTIVE: The tendency of people with ADHD to avoid tasks that require mental effort impacts their academic achievement. Findings in the literature suggest that children with ADHD find cognitive tasks more effortful and uncomfortable than their typically developing peers. However, neuropsychological processes contributing to this remain unclear. The present study investigated whether the relationship between prepotent motor response inhibition and avoiding mental effort is mediated by the ability to resist avoidance motivation and whether this proposed mediation mechanism is contingent on ADHD diagnosis. METHOD: 40 children with ADHD and 40 gender and age-matched typically developing peers participated in the study. They completed the Cognitive Effort Avoidance Measure, the Go/No-go Task, and the Reinforcement Sensitivity Theory-Personality Questionnaire-Children. Mediation and moderated mediation analyses were employed to test the hypotheses. RESULTS: Children with ADHD scored lower in response inhibition and resisting avoidance motivation. Poorer scores in these variables were associated with a higher avoidance rate. Moreover, the ability to resist avoidance motivation completely mediated the relationship between response inhibition and avoidance rate only among children with ADHD. CONCLUSION: Findings imply that poorer response inhibition led to an increase in avoidance motivation among children with ADHD, which becomes challenging to regulate effectively due to an impairment in the ability to resist avoidance motivation. Theoretical and clinical implications are discussed.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Motivação , Humanos , Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Inquéritos e Questionários
2.
Personal Neurosci ; 6: e1, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36843660
3.
Early Interv Psychiatry ; 17(11): 1095-1106, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-36669849

RESUMO

AIMS: Schizotypy reflects the vulnerability to schizophrenia in the general population. Different questionnaires have been developed to measure aspects of schizotypy. Higher schizotypy scores have also been linked with depression, anxiety, and stress sensitivity. Here we examine the associations of schizotypy with symptoms of depression and anxiety in a sample of university students, using two different measures (N = 271). METHODS: A series of confirmatory factor analyses was used to examine two distinct and frequently employed measures of schizotypy: the Community Assessment of Psychic Experiences (CAPE), and the Schizotypy Personality Questionnaire (SPQ). We assessed their relationship with each other and their predictive validity for anxiety, depression, and stress sensitivity. RESULTS: Our results indicated the brief 7-factor SPQ (SPQ-BR) factor solution for the SPQ and the 15-item and 3 factor solution for the CAPE (i.e., CAPE-P15) as best fitting models. Particularly the CAPE dimension of persecutory ideation was a strong predictor of anxiety, depression, and stress sensitivity, whereas the SPQ dimensions of no close friends and social anxiety predicted psychological distress and stress in our student sample. CONCLUSIONS: Our findings extend earlier work in general and patient samples and point to the importance of understanding the contribution of particularly positive schizotypy symptoms and different interpersonal aspects to psychological distress.


Assuntos
Angústia Psicológica , Transtorno da Personalidade Esquizotípica , Humanos , Transtorno da Personalidade Esquizotípica/diagnóstico , Transtorno da Personalidade Esquizotípica/psicologia , Universidades , Reprodutibilidade dos Testes , Inquéritos e Questionários , Estudantes/psicologia
4.
Front Psychol ; 13: 1026894, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36478928

RESUMO

This study highlights psychometric properties and evidence of construct validity on parcel-level for questionnaires on the original and revised reinforcement sensitivity theory. Our data (N = 1,076) suggest good to very good psychometric properties and moderate to excellent internal consistencies. Confirmatory factor analysis (CFA) models suggest a very good model fit for the first-order, four factor models of the Carver-White BIS/BAS scales, Reinforcement Sensitivity Theory - Personality Questionnaire (RST-PQ), the two-factor model of revised Reinforcement Sensitivity Theory-Questionnaire (rRST-Q) and for the bifactor model of the Conflict Monitoring Questionnaire (CMQ-44). The CMQ-44 extends the psychometric measurement of previous trait-(r)BIS and trait-BAS scales. Factor scores of CMQ-44 cognitive demand correlate positively with factor scores of Carver-White BIS and all Carver-White BAS subfactors except RST-PQ-Impulsivity suggesting that CMQ-44 cognitive demand addresses Carver-White trait-BIS specifically and more generally the trait-BAS core. CMQ-44 anticipation of negative consequences and response adaptation correlate negatively with trait-BAS, whereas the second-order factor performance monitoring extends the rRST trait-space and correlates positively with trait-BAS.

5.
Span J Psychol ; 25: e8, 2022 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-35164894

RESUMO

This study aimed to adapt and validate the Spanish version of the Reinforcement Sensitivity Theory-Personality Questionnaire (RST-PQ; Corr & Cooper, 2016) and to demonstrate how RST constructs are associated with a variety of everyday behaviors. To achieve this goal, three studies have been conducted. In Study 1, a direct translation of the items from English to Spanish was pilot-tested in a sample of 139 students and a descriptive analysis of items was conducted. Moreover, a reverse translation and comparison between the two English versions were carried out by the lead author of the original questionnaire and the items were refined accordingly. In Study 2, the questionnaire's internal structure was assessed using exploratory and confirmatory factor analyses and the predictive validity was assessed using the Criterion Set of Act Clusters in a sample of 1,281 participants. Finally, a study of convergent validity with other measures of personality was performed in Study 3 with 190 participants. The obtained results suggested that the RST-PQ has adequate psychometric properties and the convergent validity results with other personality measures replicate findings from previous research. Having a Spanish language version of the RST-PQ is important, not only to advance RST research but also to demonstrate that this theoretical approach contributes to the prediction and explanation of different behaviors whether they are healthy or pathological ones.


Assuntos
Idioma , Personalidade , Humanos , Psicometria , Reforço Psicológico , Reprodutibilidade dos Testes , Inquéritos e Questionários
6.
Curr Psychol ; : 1-15, 2022 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-35095249

RESUMO

Two studies examined genetic and environmental influences on traits proposed by the revised Reinforcement Sensitivity Theory (rRST) of personality. Both quantitative and molecular behavioral genetic methods were applied considering the effects of COMT, DRD2, HTR1A and TPH2 single nucleotide polymorphisms (SNPs). Study one included 274 monozygotic and 154 dizygotic twins for the quantitative behavioral study; and in study two there were 431 twins for the molecular genetic study. The Reinforcement Sensitivity Questionnaire was used to assess basic personality traits defined by the rRST. Univariate biometric modeling suggested that genetic influences accounted for 34-44% of variance of Behavioral Approach System (BAS), Behavioral Inhibition System (BIS) and Fight-Fligh-Freeze System. Molecular genetic analyses proposed the significant main effect of COMT SNP on the BAS and TPH2 SNP on the BIS, and pointed out epistatic effects of COMT x DRD2 on BAS and HTR1A x TPH2 on Fight. Results demonstrated substantial heritability for all rRST constructs, as well as for differences in the molecular genetic basis of both approach-related and avoidance-related dimensions.

7.
J Pers Assess ; 103(2): 246-257, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32242753

RESUMO

We examine the structural overlap of the Behavioral Inhibition System (BIS) and the Behavioral Approach System (BAS) with Stability and Plasticity, the two higher-order factors encompassing the Big Five. Carver and White's BIS/BAS and the Big Five Inventory were administered to a sample of 330 adults, serving both as targets and informants. Self- and other-ratings were modeled by using the Correlated Trait-Correlated Method model. BIS and BAS correlated highly with metatraits, after method variance and measurement error were partialled out: BIS was positively related to Stability, while BAS was positively related to Plasticity and negatively related to Stability. After the higher-order factors were controlled, the BIS was highly and positively related to Emotional stability, whereas the BAS had a small but significant relationship with Extraversion. Findings are discussed with regard to the most appropriate level of generality/specificity at which the personality correlates of BIS and BAS can be investigated.


Assuntos
Extroversão Psicológica , Inibição Psicológica , Determinação da Personalidade/normas , Personalidade , Adulto , Atenção/fisiologia , Emoções , Feminino , Humanos , Masculino , Transtornos da Personalidade/psicologia , Psicometria , Adulto Jovem
8.
J Pers Assess ; 103(4): 523-534, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32496822

RESUMO

Revised reinforcement sensitivity theory (r-RST) of personality is a major neuropsychological theory of motivation, emotion and personality. This paper presents the results of a study examining: (1) the factor structure of the Reinforcement Sensitivity Theory of Personality Questionnaire (RST-PQ) using confirmatory factor analysis (CFA) and exploratory structural equation modeling (ESEM); and (2) the relationships of the r-RST constructs in the RST-PQ with attention deficit hyperactivity disorder (ADHD) symptom groups of inattention (IA) and hyperactivity/impulsivity (HI). A total of 572 (Sample 1) and 309 (Sample 2) adults completed the RST-PQ. Participants in Sample 2 also completed a questionnaire measuring ADHD symptoms. Results revealed more support for the ESEM model with six factors than the CFA model. For both the ESEM and CFA models, both IA and HI symptom groups were associated positively with the RST-PQ constructs of behavioral inhibition system (BIS) and behavioral approach system (BAS) Impulsivity, with IA also associated negatively with the BAS-Goal-Drive Persistence. The theoretical implications of these findings for understanding the factor structure of the RST-PQ, and for ADHD (IA and HI) in terms of r-RST, are discussed.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Inibição Psicológica , Personalidade , Reforço Psicológico , Adulto , Emoções , Análise Fatorial , Feminino , Humanos , Comportamento Impulsivo , Masculino , Motivação , Transtornos da Personalidade/psicologia , Inquéritos e Questionários
9.
J Pers Assess ; 103(4): 535-546, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32783537

RESUMO

We conducted three studies (total n = 998) aimed at developing and validating a shortened version of the Reinforcement Sensitivity Theory of Personality Questionnaire (i.e., the RST-PQ-S). In Study 1 (n = 341), twenty-two items were selected from the original RST-PQ, based on both theoretical and empirical criteria. Confirmatory factor analysis (CFA) on this short-form supported the six-factor structure comprising: FFFS, BIS, and four BAS components (Reward Interest, Goal Drive-Persistence, Reward Reactivity, and Impulsivity). The six scale scores showed adequate levels of internal consistency. Construct validity was supported by correlations with established personality measures. In Study 2 (n = 340), CFA results were cross-validated in an independent sample and construct validity was supported by correlations with BIS/BAS scales. In Study 3 (n = 317) test-retest correlations showed acceptable-to-good levels of temporal stability over a four-week interval. Results revealed a substantial overlap with original, full-length RST-PQ, providing evidence for the comparability of the two versions. Latent State-Trait analyses showed that the items of the RST-PQ-S mostly capture interindividual differences that are stable across situations. Taken together, findings indicate that the RST-PQ-S provides an efficient, valid and reliable alterative to the longer RST-PQ.


Assuntos
Comportamento Impulsivo , Personalidade , Reforço Psicológico , Inquéritos e Questionários/normas , Adulto , Análise Fatorial , Humanos , Masculino , Motivação , Inventário de Personalidade , Psicometria , Reprodutibilidade dos Testes , Adulto Jovem
10.
Front Psychol ; 11: 566237, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33324279

RESUMO

Behavioral immune system (BIS) describes psychological mechanisms that detect cues to infectious pathogens in the immediate environment, trigger disease-relevant responses and facilitate behavioral avoidance/escape. BIS activation elicits a perceived vulnerability to disease (PVD) which can result in conformity with social norms. However, a response to superficial cues can result in aversive responses to people that pose no actual threat, leading to an aversion to unfamiliar others, and likelihood of prejudice. Pathogen-neutralizing behaviors, therefore, have implications for social interaction as well as illness behaviors and responses to health communications. In this study, we investigate how PVD influences conformity, attitudes to other people and to lockdown regulations through the lens of the Reinforcement Sensitivity Theory (RST). RST describes personality in terms of biologically-driven approach and avoidance motivations which support personal goals. Participants from the United Kingdom public (N = 605) completed an RST personality questionnaire and then read either (a) coronavirus morbidity-mortality statistics and current United Kingdom government lifestyle regulations, (b) just the regulations (as presented in most government publicity materials), or (c) no information at all. They all completed the Perceived Vulnerability to Disease scale to assess BIS-relevant Germ Aversion and Perceived Infectability, followed by questions measuring social conformity, warmth toward others and attitudes toward lockdown measures. Significantly lower PVD scores were observed in the no-information condition, with the other conditions showing no difference. In terms of RST, approach behaviors related to goal-drive persistence work alongside fear in explaining conformity to social norms. Reward related approach behaviors partially explained warmth toward others, indicating that social rewards gained through interaction continue to be strong drivers of behavior. We found no role for RST traits in attitudes toward lockdown. Overall, coronavirus-related behavior is not driven purely by fear, but also by social and/or protection goals regulated by approach motivation. This study presents new insights into public perceptions of coronavirus and government regulated lifestyle restrictions, helping to explain social behaviors in terms of biologically driven mechanisms. Such understanding is vital if we are to successfully motivate public behavior to constrain spread of the virus.

11.
Personal Neurosci ; 3: e6, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32596627

RESUMO

Gray's theory of personality postulates that fear and anxiety are distinct emotional systems with only the latter being sensitive to anxiolytic drugs. His work was mainly based on animal research, and translational studies validating his theory are scarce. Previous work in humans showed an influence of the benzodiazepine lorazepam on both systems, however, dependent on dosage (1 and 2 mg) and personality differences in negative emotionality. The present study aims to replicate these findings, and in addition tests the drug threshold effect by introducing a lower dosage of 0.5 mg lorazepam. Fifty healthy adults (23 males, agemean 22.40, SD ± 3.68) participated in an experimental threat-avoidance paradigm designed to dissociate risk assessment intensity (RAI, reflecting anxiety) and flight intensity (FI, reflecting fear) and completed two self-report questionnaires assessing facets of negative emotionality (Spielberger State Trait Anxiety Inventory and Fear Survey Schedule). In a randomized placebo-controlled within-subjects design, 0.5 and 1 mg of lorazepam were applied per os. Saccadic peak velocity was assessed by means of eye-tracking in order to control for sedating drug effects. Results showed the expected and specific anxiolytic effect of lorazepam on RAI, however, only in the 0.5 mg condition. FI was not influenced by lorazepam, and previous findings of interaction effects of lorazepam with self-reported negative emotionality could not be corroborated. Overall, this study demonstrates anxiolytic effects of lorazepam in dosages ≤1 mg in the absence of a drug effect on fear using a translational behavioural task. However, a putative moderating role of personality on defensive behaviour has to be clarified in future research.

12.
Br J Health Psychol ; 25(4): 839-848, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32348015

RESUMO

Objectives Public behaviour change is necessary to contain the spread of coronavirus (COVID-19). Based on the reinforcement sensitivity theory (RST) framework, this study presents an examination of individual differences in some relevant psychological factors. Design Cross-sectional psychometric. Methods UK respondents (N = 202) completed a personality questionnaire (RST-PQ), measures of illness attitudes, concerns about the impact of coronavirus on health services and socio-economic infrastructures, personal safety, and likelihood of voluntary self-isolation. Results Respondents most concerned were older, had negative illness attitudes, and scored higher on reward reactivity (RR), indicating the motivation to take positive approach action despite prevailing worry/anxiety. Personal safety concerns were highest in those with negative illness attitudes and higher fight-flight-freeze system (FFFS, reflecting fear/avoidance) scores. Results suggest people are experiencing psychological conflict: between the urge to stay safe (FFFF-related) and the desire to maintain a normal, pleasurable (RR-related) life. Ways of ameliorating conflict may include maladaptive behaviours (panic buying), reflecting reward-related displacement activity. Intended self-isolation related to FFFS, but also low behavioural inhibition system (related to anxiety) scores. Older people reported themselves less likely to self-isolate. Conclusions Interventions need to consider individual differences in psychological factors in behaviour change, and we discuss relevant literature to inform policy makers and communicators. Statement of contribution What is already known on this subject? Reinforcement sensitivity theory (RST) personality systems can influence perception of persuasive health messages. However, there is limited evidence for their direct effects on health concerns and behaviours, and none relating to specific infectious diseases. What does this study add? Reward reactivity (RR) is associated with concern about impact of coronavirus on the NHS and other social infrastructures, indicating the motivation to take positive-approach action despite worry/anxiety. Personal safety concerns are related to fight-flight-freeze system traits (FFFS, reflecting fear/avoidance). Intended self-isolation related to FFFS, but also low behavioural inhibition system (related to anxiety) scores. Older people reported themselves less likely to self-isolate. Results suggest psychological conflict: between the urge to stay safe (FFFF-related) and the desire to maintain a normal, pleasurable life (RR-related). Ways of ameliorating conflict may include maladaptive behaviours (panic buying), reflecting reward-related displacement activity.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Intenção , Pandemias , Pneumonia Viral , COVID-19 , Estudos Transversais , Humanos , Personalidade , SARS-CoV-2 , Reino Unido
13.
J Affect Disord ; 266: 595-602, 2020 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-32056932

RESUMO

BACKGROUND: Anxiety disorders are highly comorbid with major depression but differ in their symptom profiles and pharmacological responses. Threat-sensitivity may explain such differences, yet research on its relationship to specific disorders is lacking. METHODS: One-hundred patients (71 women) and 35 healthy controls (23 women) were recruited. Thirty-five had Panic Disorder (PD), 32 had Generalized Anxiety Disorder (GAD) and 33 Major Depressive Disorder (MDD). Threat-sensitivity was measured via behaviour (Joystick Operated Runway Task; JORT) and self-report (Fear Survey Schedule; FSS). RESULTS: Behavioural sensitivity to simple threat was higher in females compared to males (p = .03). Self-reported sensitivity to simple threat (FSS Tissue Damage Fear) was higher in PD patients compared to other groups (p ≤ .007) and in GAD patients compared to controls (p = .02). Behavioural sensitivity to complex threat was higher in females than males (p = .03) and a group by sex interaction (p = .01) indicated that this difference was largest in PD patients. Self-reported sensitivity to complex threat (FSS Social Fear) was higher in all patients compared to controls (p ≤ .001). Females scored higher than males on FSS Tissue Damage Fear and FSS Social Fear). CONCLUSIONS: Our findings oppose the simple/complex threat dichotomy, instead suggesting elevated sensitivity to physical threat differentiates anxiety disorders from MDD, whereas elevated sensitivity to social threat is associated with both anxiety disorders and MDD.


Assuntos
Transtorno Depressivo Maior , Transtorno de Pânico , Transtornos de Ansiedade/epidemiologia , Estudos de Casos e Controles , Transtorno Depressivo Maior/epidemiologia , Medo , Feminino , Humanos , Masculino , Transtorno de Pânico/epidemiologia
14.
Br J Educ Psychol ; 90(1): 152-166, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30741407

RESUMO

BACKGROUND: Academic dishonesty (AD) is an increasing challenge for universities worldwide. The rise of the Internet has further increased opportunities for students to cheat. AIMS: In this study, we investigate the role of personality traits defined within Reinforcement Sensitivity Theory (RST) as potential determinants of AD. RST defines behaviour as resulting from approach (Reward Interest/reactivity, goal-drive, and Impulsivity) and avoidance (behavioural inhibition and Fight-Flight-Freeze) motivations. We further consider the role of deep, surface, or achieving study motivations in mediating/moderating the relationship between personality and AD. SAMPLE: A sample of UK undergraduates (N = 240). METHOD: All participants completed the RST Personality Questionnaire, a short-form version of the study process questionnaire and a measure of engagement in AD, its perceived prevalence, and seriousness. RESULTS: Results showed that RST traits account for additional variance in AD. Mediation analysis suggested that GDP predicted dishonesty indirectly via a surface study approach while the indirect effect via deep study processes suggested dishonesty was not likely. Likelihood of engagement in AD was positively associated with personality traits reflecting Impulsivity and Fight-Flight-Freeze behaviours. Surface study motivation moderated the Impulsivity effect and achieving motivation the FFFS effect such that cheating was even more likely when high levels of these processes were used. CONCLUSIONS: The findings suggest that motivational personality traits defined within RST can explain variance in the likelihood of engaging in dishonest academic behaviours.


Assuntos
Sucesso Acadêmico , Enganação , Personalidade/fisiologia , Comportamento Social , Estudantes , Adulto , Feminino , Humanos , Masculino , Técnicas Psicológicas , Reforço Psicológico , Reino Unido , Universidades , Adulto Jovem
15.
Behav Brain Sci ; 42: e132, 2019 08 13.
Artigo em Inglês | MEDLINE | ID: mdl-31407998

RESUMO

Gain or omission/termination of loss produces approach; while loss or omission/termination of gain produces withdrawal. Control of approach/withdrawal motivation is distinct from valuation of gain/loss and does not entail learning - making "reward" and "punishment" ambiguous. Approach-withdrawal goal conflict engages a neurally distinct Behavioural Inhibition System, which controls "anxiety" (conflict/passive avoidance) but not "fear" (withdrawal/active avoidance).


Assuntos
Aprendizagem da Esquiva , Inibição Psicológica , Motivação , Punição , Recompensa
16.
Personal Neurosci ; 2: e4, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-32435739

RESUMO

As demonstrated by neuroimaging data, the human brain contains systems that control responses to threat. The revised Reinforcement Sensitivity Theory of personality predicts that individual differences in the reactivity of these brain systems produce anxiety and fear-related personality traits. Here we discuss some of the challenges in testing this theory and, as an example, present a pilot study that aimed to dissociate brain activity during pursuit by threat and goal conflict. We did this by translating the Mouse Defense Test Battery for human fMRI use. In this version, dubbed the Joystick Operated Runway Task (JORT), we repeatedly exposed 24 participants to pursuit and goal conflict, with and without threat of electric shock. The runway design of JORT allowed the effect of threat distance on brain activation to be evaluated independently of context. Goal conflict plus threat of electric shock caused deactivation in a network of brain areas that included the fusiform and middle temporal gyri, as well as the default mode network core, including medial frontal regions, precuneus and posterior cingulate gyrus, and laterally the inferior parietal and angular gyri. Consistent with earlier research, we also found that imminent threat activated the midbrain and that this effect was significantly stronger during the simple pursuit condition than during goal conflict. Also consistent with earlier research, we found significantly greater hippocampal activation during goal conflict than pursuit by imminent threat. In conclusion, our results contribute knowledge to theories linking anxiety disorders to altered functioning in defensive brain systems and also highlight challenges in this research domain.

17.
Personal Neurosci ; 2: e12, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-32435747

RESUMO

Using electroencephalography (EEG) power measures within conventional delta, theta, alpha, beta, and gamma bands, the aims of the current study were to highlight cortical correlates of subjective perception of cold pain (CP) and the associations of these measures with behavioral inhibition system (BIS), fight-flight-freeze system (FFFS), and behavioral approach system personality traits. EEG was recorded in 55 healthy right-handed women under (i) a white noise interruption detection condition (Baseline); (ii) enduring CP induced by the cold cup test. CP and Baseline EEG band power scores within conventional frequency bands served for covariance analyses. We found that: (1) higher Pain scorers had higher EEG beta power changes at left frontal, midline central, posterior temporal leads; (2) higher BIS was associated with greater EEG delta activity changes at parietal scalp regions; (3) higher FFFS was associated with higher EEG delta activity changes at temporal and left-parietal regions, and with lower EEG gamma activity changes at right parietal regions. High FFFS, compared to Low FFFS scorers, also showed a lower gamma power across the midline, posterior temporal, and parietal regions. Results suggest a functional role of higher EEG beta activity in the subjective perception of tonic pain. EEG delta activity underpins conflict resolution system responsible for passive avoidance control of pain, while higher EEG delta and lower EEG gamma activity changes, taken together, underpin active avoidance system responsible for pain escape behavior.

18.
J Psychopharmacol ; 32(6): 678-690, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29783905

RESUMO

BACKGROUND: Saccadic eye movements are controlled by a network of parietal, frontal, striatal, cerebellar and brainstem regions. The saccadic peak velocity is an established biomarker of benzodiazepine effects, with benzodiazepines reliably reducing the peak velocity. AIMS: In this study, we aimed to replicate the effects of benzodiazepines on peak velocity and we investigated effects on previously less studied measures of saccades. We also explored the roles of sex, task characteristics and the baseline variables age, intelligence and trait anxiety in these effects. METHOD: Healthy adults ( N = 34) performed a horizontal step prosaccade task under 1 mg lorazepam, 2 mg lorazepam and placebo in a double-blind, within-subjects design. RESULTS: We replicated the dose-dependent reduction in peak velocity with lorazepam and showed that this effect is stronger for saccades to targets at smaller eccentricities. We also demonstrated that this effect is independent of sex and other baseline variables. Lorazepam effects were widespread, however, occurring on mean and variability measures of most saccadic variables. Additionally, there were sex-dependent lorazepam effects on spatial consistency of saccades, indicating more adverse effects in females. CONCLUSIONS: We conclude that saccadic peak velocity is a sensitive and robust biomarker of benzodiazepine effects. However, lorazepam has pronounced effects also on other parameters of horizontal saccades. Sex-dependent drug effects on spatial consistency may reflect cerebellar mechanisms, given the role of the cerebellum in saccadic spatial accuracy.


Assuntos
Ansiolíticos/administração & dosagem , Benzodiazepinas/administração & dosagem , Lorazepam/administração & dosagem , Movimentos Sacádicos/efeitos dos fármacos , Adulto , Ansiolíticos/efeitos adversos , Ansiolíticos/farmacologia , Benzodiazepinas/efeitos adversos , Benzodiazepinas/farmacologia , Relação Dose-Resposta a Droga , Método Duplo-Cego , Feminino , Humanos , Lorazepam/efeitos adversos , Lorazepam/farmacologia , Masculino , Fatores Sexuais , Adulto Jovem
19.
20.
Int J Psychophysiol ; 120: 108-117, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-28739481

RESUMO

Band power linked to lower and upper alpha (i.e. 8-10Hz; 10-12Hz) and lower and upper beta (i.e. 12-20Hz; 20-30Hz) were examined during response related stages, including anticipation, response execution (RE), response inhibition (RI) and post response recovery (PRR). Group and individual data from 34 participants were considered. The participant's objective was to press a response key immediately following 4 non-repeating, single integer odd digits. These were presented amongst a continuous stream of digits and Xs. Electroencephalogram (EEG) signals were recorded from 32 electrodes (pooled to 12 regions). In the group analyses, participant EEG response was compared to baseline revealing that upper alpha desynchronised during anticipation, RE and RI; lower beta during anticipation and RE; and upper beta just RE. Upper alpha desynchronisation during rapid, unplanned RI is novel. Also, upper alpha and lower/upper beta synchronised during PRR. For upper alpha, we speculate this indexes brief cortical deactivation; for beta we propose this indexes response set maintenance. Lastly, lower alpha fluctuations correlated negatively with RT, indexing neural efficiency. Individual analyses involved calculation of the proportion of individuals displaying the typical RE and PRR trends; these were not reflected by all participants. The former was displayed individually by the largest proportion in upper alpha recorded left fronto-centrally; the latter was most reliably displayed individually in lower beta recorded mid centro-parietally. Therefore, group analyses identified typical alpha and beta synchronisation/desynchronisation trends, whilst individual analyses identified their degree of representation in single participants. Attention is drawn to the clinical relevance of this issue.


Assuntos
Ritmo alfa/fisiologia , Ritmo beta/fisiologia , Ondas Encefálicas/fisiologia , Córtex Cerebral/fisiologia , Movimento/fisiologia , Adolescente , Adulto , Análise de Variância , Mapeamento Encefálico , Eletroencefalografia , Feminino , Seguimentos , Humanos , Inibição Psicológica , Masculino , Pessoa de Meia-Idade , Desempenho Psicomotor/fisiologia , Tempo de Reação/fisiologia , Adulto Jovem
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