Anastomotic Leakage after Colorectal Surgery in Ovarian Cancer: Drainage, Stoma Utility and Risk Factors.

Objective: to evaluate the incidence of anastomotic leakage (AL), risk factors and utility of drainage and stoma in patients undergoing intestinal surgery for ovarian cancer in a single institution and in a review of the literature. Methods: retrospective study that includes consecutive patients undergoing debulking surgery with en bloc pelvic resection with rectosigmoid colectomy for ovarian cancer between 1 November 2011 and 31 December 2021. Data regarding patient and tumour characteristics, surgical procedure, hospitalisation, complications and follow-up were recorded and analysed. The PubMed database was explored for recent publications on this topic. Results: Seventy-five patients were enrolled in the study. All anastomoses were performed at a distance of >6 cm from the anal margin, with negative leak tests and tension-free anastomosis. Diverting stoma were performed in just three patients (4%). At least one perianastomotic pelvic drain was positioned in 71 patients (94.7%) and was removed on average on postoperative day 7. Four patients (5.3%) experienced AL. In all cases, the drain content was not the only sign of complication, as the clinical signs were also highly suggestive. Just one patient received conservative treatment. Average postoperative hospitalisation was 14.6 days (SD: ±9.7). There were no deaths at 30 and 60 days after surgery. Between the AL and non-AL groups, statistically significant differences were observed for age, Charlson Comorbidity Index, length of the intestinal resection and fitness for chemotherapy at 30 days. In ovarian cancer, rectosigmoid resection is a standardised procedure with comparable results for AL, and risk factors for AL are discretely homogeneous. What is neither homogeneous nor standardised according to the literature is the use of stomas and/or drains. Conclusion: use in the future of protective stoma and/or intra-abdominal drains is to be explored in selected and standardised situations to verify their preventive role.

Noninvasive detection of coronary artery stenosis with 16-slice spiral computed tomography in a population at low to moderate risk for coronary artery disease.

OBJECTIVE: To evaluate the feasibility and accuracy of 16-slice spiral computed tomography (MSCT) in detecting coronary artery lesions in a low to moderate risk population. METHODS: MSCT was performed in 33/78 patients at low to moderate risk for coronary artery disease affected by mitral and/or aortic valve disease and scheduled for conventional coronary angiography for pre-surgery evaluation. The sensitivity (SE), specificity (SP), positive (PPV) and negative predictive values (NPV) to identify >or=50% obstructed lesions were evaluated. Moreover, a discriminant predictive statistical analysis was performed. RESULTS: MSCT visualised 428/479 (89%) segments identified at coronary angiography and the percentage of evaluable segments was 87%. By including all coronary branches, SE, SP, PPV and NPV were 69%, 96%, 58% and 97%, respectively. By excluding the segments with a diameter of