Complementary and Integrative Medicine in academic health education.

OBJECTIVE: To analyze academic education in Complementary and Integrative Medicine (CIM) according to university students from the health area. METHODS: Cross-sectional study with 1399 students from six public and private Brazilian universities, with online and in-person collection of socioeconomic, demographic, educational and academic data, carried out in 2019. The bivariate analysis was applied for the outcome "presence of CIM in academic health education", using the SPSS Statistic program, version 23.0™. RESULTS: The prevalence of the presence of CIM in academic health education was 52.3%, being 31.1% in the compulsory and 8% in the non-compulsory curricular education, 2.0% in scientific research and 4.7% in university extension activities. There was an association of the outcome with knowledge of the national CIM policy (OR = 5.258; p = 0.000), of which knowledge can be indicated and used in one's professional area (OR = 4.836; p = 0.000), interest and/or use of CIM by the teachers/tutors of the course (OR = 3.955; p = 0.000), stimulus by the university to carry out scientific research (OR = 3.277; p = 0.000) and university extension projects with CIM (OR = 3.686; p = 0.000). CONCLUSION: Academic education using CIM in health area courses is not very prevalent in teaching, research and university extension in Brazil, but when present in the curricular and non-curricular educational processes, it shows a significant association with knowledge, skills and their use by university students. The creation of a National Educational Planning in CIM is a vital imperative.

Estudo comparativo de antraciclicos na indução de cardiotoxicidade experimental: parâmetros eletro e ecocardiográficos, marcadores bioquímicos, alterações morfo-funcionais e abordagem farmacológica / Comparative study of anthracycline cardiotoxicity in experimental induction: electro and echocardiographic parameters, biochemical markers, morphological and functional changes and pharmacological approach

A cardiotoxicidade específica, que se desenvolve após doses cumulativas de antraciclinas, é o principal efeito limitante para o tratamento a longo prazo com estes agentes. Vários modelos animais reproduzindo as alterações morfológicas, bioquímicas e funcionais induzidas por doxorubicina, têm sido descritos e usados para testar novos análogos. Em estudos anteriores desenvolvemos um modelo de tratamento "in vivo" para estudo da cardiotoxicidade induzida por antracíclicos em ratos em que, consistentes e significativas alterações da função miocárdica puderam ser observadas e mensuradas em intervalo de tempo relativamente curto. O objetivo do presente estudo foi validar o modelo proposto para avaliação da cardiotoxicidade induzida por doxorubicina em ratos, usando a epirubicina (EPI), idarubicina (IDA) e mitoxantrona (MIT). Além de avaliar o potencial cardioprotetor da talidomida e pentoxifilina. Os parâmetros utilizados nesta avaliação foram: estudo eletro e ecocardiográfico; dosagem sérica dos marcadores bioquímicos (troponina T, CK-MB, LDH); curva ponderal; parâmetros hematológicos, índices cardíaco, hepático, esplênico e análise histopatológica...