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1.
J Clin Pathol ; 57(4): 369-73, 2004 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15047739

RESUMO

AIMS: To determine the agreement between clinical and necropsy diagnoses of the basic cause of death, and to compare the results with those obtained in a previous study carried out at the same university hospital. METHODS: In total, 4828 necropsies, performed between 1990 and 1995 in the University Hospital of the Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil, were reviewed. Examinations were concluded at the macroscopic part of the necropsy in nearly 35% of the cases. Statistical analysis was carried out using the kappa coefficient comparing the clinical diagnosis and the diagnosis obtained after necropsy. The jackknife method was used to identify comparable kappa values for the comparison of the two periods. RESULTS: Compared with the 1978-80 period, a significant increase in diagnostic agreement was seen for the group submitted to complete necropsy, whereas no similar increase was detected when only the macroscopic step was analysed. CONCLUSIONS: There was a discrete tendency to an improved correlation between clinical and postmortem data stated by full necropsy analysis. The findings show that microscopic analysis remains important to confirm the cause of death in many cases. Diagnostic discrepancies remained high, and therefore complete necropsy continues to be an essential instrument for the assessment of clinical diagnosis.


Assuntos
Causas de Morte , Diagnóstico , Autopsia/métodos , Hospitais Universitários , Humanos , Sensibilidade e Especificidade , Estatística como Assunto
2.
Braz J Med Biol Res ; 27(1): 91-4, 1994 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-8173534

RESUMO

Rhodium (II) trifluoroacetate (TFARh), rhodium (II) trifluoroacetate adduct with sulfadiazine (TFARh.Sd) and rhodium (II) acetate adduct with sulfisoxazole (RhSx) were tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and for viability of Ehrlich tumor cells in culture. At ip doses up to 60 mumol/kg (40-70 and 59 mg/kg, respectively), these compounds had no toxic effects up to 14 days. At ip doses of 10 mumol kg-1 day-1 for 5 days, TFARh and TFARh.Sd significantly increased the survival rate of mice bearing Ehrlich ascites cells (probability of survival to the end of 34th day, controls = 0.23, TFARh = 0.85, TFARh.Sd = 0.74). No significant effect was observed for RhSx. In vitro, these rhodium complexes at 40 microM significantly increased the number of dead cells in cultured Ehrlich tumor cells.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia , Carcinoma de Ehrlich/tratamento farmacológico , Ródio/farmacologia , Acetatos/administração & dosagem , Animais , Carcinoma de Ehrlich/mortalidade , Ensaios de Seleção de Medicamentos Antitumorais , Camundongos , Camundongos Endogâmicos BALB C , Sulfadiazina/administração & dosagem , Sulfisoxazol/administração & dosagem , Taxa de Sobrevida , Fatores de Tempo , Ácido Trifluoracético/administração & dosagem
3.
Braz. j. med. biol. res ; 27(1): 91-4, jan. 1994. tab
Artigo em Inglês | LILACS | ID: lil-136497

RESUMO

Rhodium (II) trifluoracetate (TFARh), rhodium (II) trifluoracetate adduct with sulfadiazine (TFARh.Sd) and rhodium (II) acetate adduct with sulfisoxazole (RhSx) were tested in mice for acute toxicity, antitumoral activity against Ehrlich ascites carcinoma and for viability of Ehrlich tumor cells in culture. At ip doses up to 60 µmg/kg (40-70 and 59 mg/kg, respectively), these coumpounds had no toxic effects up to 14 days. At ip doses of 10 µmol Kg-1 day-1 for 5 days, TFARh and TFARh.Sd significantly increased the survival rate of mice bearing Ehrlich ascites cells (probability of survival to the end of 34th day, controls = 0.23, TFARh = 0.85, TFARh.Sd = 0.74). No significant effect was observed for RhSx. In vitro, these rhodium complexes at 40 µM significantly increased the number of dead cells in cultured Ehrlich tumor cells


Assuntos
Camundongos , Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia , Carcinoma de Ehrlich/tratamento farmacológico , Técnicas In Vitro , Ródio/farmacologia , Acetatos/administração & dosagem , Carcinoma de Ehrlich/mortalidade , Camundongos Endogâmicos BALB C , Sulfadiazina/administração & dosagem , Sulfisoxazol/administração & dosagem , Fatores de Tempo , Ácido Trifluoracético/administração & dosagem
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