Hot flushes, hypertension and haemodialysis.

Hypertension is common in patients with end stage renal disease. However, in patients non-responsive to standard measures to control the blood pressure, non-renal causes should be considered. We present the case of a patient on haemodialysis with difficult to control blood pressure.

Micrometastases in thyroid cancer. An important finding?

Differentiated thyroid cancer is a cancer with a good prognosis but the presence of lymph node metastases is associated with increased rates of loco-regional recurrence and in some reports decreased survival. This has led to an increased interest in the lymph node status with guidelines calling for routine central node dissection and increased interest in lateral compartment node sampling and sentinel node biopsy. We know from studies in regions where routine central and ipsilateral node dissection is the preferred surgical management of differentiated thyroid cancer that lymph node metastases are present in the majority of cases and that many of these are micrometastatic deposits. However, where routine node dissection is not performed recurrence rates are relatively low suggesting that not all micrometastatic disease progresses to a loco-regional recurrence or that the majority of disease is mopped up by adjuvant radioactive iodine. This review examines the available evidence for the significance of micrometastatic disease in differentiated thyroid cancer and suggests that it is probably of little clinical significance and does not warrant further aggressive surgical intervention. We would expect a conservative surgical approach combined with adjuvant radioactive iodine to lead to durable disease control.

Intraoperative parathormone measurement from the internal jugular vein predicts post-thyroidectomy hypocalcaemia.

BACKGROUND: The most common significant complication of total thyroidectomy is hypoparathyroidism. Intraoperative prediction of which patients are likely to be affected would allow both intraoperative and postoperative interventions to be utilised in these patients. Selection of these patients is essential if we are to be successful at discharging total thyroidectomy patients on the first postoperative day. We investigated the utility of intraoperative parathormone measurement from the internal jugular vein at predicting postoperative hypocalcaemia. MATERIALS AND METHODS: Prospective collection of data was done on 45 consecutive total thyroidectomy patients. Preoperative calcium, intraoperative parathormone and postoperative calcium and parathormone were collected. The accuracy of intraoperative parathormone in predicting those with postoperative hypocalcaemia was assessed. RESULTS: Intraoperative parathormone of less than 2 pmol l(-1) had a sensitivity of 100% and a specificity of 95% in predicting those with postoperative hypocalcaemia. An intraoperative sample less than 2 pmol l(-1) was a highly significant predictor (p < 0.0001) of postoperative hypocalcaemia. CONCLUSION: Intraoperative assessment of parathormone is an accurate predictor of those patients who will become hypoparathyroid in the postoperative period. Intraoperative prediction allows for targeted autotransplantation of glands in those at risk and selected early institution of postoperative supplementation in these patients. Patients not identified as at risk can be safely discharged.

Aortic aneurysm repair in a peripheral setting: audit 100 consecutive cases.

BACKGROUND: Subspecialization of vascular surgery and the advent of endovascular techniques for aortic aneurysm repair have had a large impact on the approach to aortic surgery in main centres. Centralization of vascular surgery has been proposed to lower mortality and morbidity rates. More recently, clinical governance standards have been set by professional bodies for acceptable adverse outcome rates in aortic surgery. A peripheral general surgeon's experience with aortic surgery is reviewed in the present report in order to identify the local adverse outcome rates, and to relate them to case data and governance recommendations. METHODS: A retrospective audit of 100 cases of elective and emergency aortic aneurysm repair (performed by the senior author over a 10-year period) was undergone for the present review. Demographic and outcome data were recorded, and a data analysis was performed to identify factors related to mortality. Significance was tested using chi-squared analysis. RESULTS: Postoperative mortality rates were 1.7% for elective cases and 21% for acute cases. Mortality was related to rupture of the aneurysm, blood loss and American Society of Anesthetists score > 3. CONCLUSION: Morbidity and mortality rates from this audit compare favourably with those from larger vascular units. They are well within the accepted clinical governance rates, although the latter do not account for any case mix variation which may exist between peripheral and tertiary referral centres. These results support the continuation of aortic aneurysm surgery in peripheral centres.