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OBJECTIVE: Programmed cell death-ligand 1 (PD-L1) expression has been shown to play important roles in various types of cancer. However, the role of PD-L1 expression has not been conclusively reported in patients with oral squamous cell carcinoma (OSCC). Accordingly, in this meta-analysis, we investigated the clinicopathological value of PD-L1 expression in patients with OSCC. METHODS: Google Scholar, PubMed, EMBASE, and CNKI databases were searched to find relevant studies published through to September 16, 2019. The relationships between PD-L1 expression in patients with OSCC and clinicopathological features were assessed using risk ratio (RR) and 95% confidence intervals (CIs). RESULTS: Sixteen studies including 1989 participants were included. The results indicated that high PD-L1 expression was correlated with sex (RR = 1.28, 95% CI: 1.16-1.42, P < 0.001), N stage (RR = 1.19, 95% CI: 1.06-1.33, P = 0.003), M stage (RR = 1.64, 95% CI: 1.01-2.66, P = 0.044), low differentiation (RR = 1.16, 95% CI: 1.01-1.33, P = 0.034), and human papilloma virus infection (RR = 1.38, 95% CI: 1.14-1.68, P = 0.001), but unrelated to TNM stage or T stage. There was no significant publication bias in the studies included in this analysis. CONCLUSIONS: This meta-analysis revealed that high PD-L1 expression in patients with OSCC was correlated with clinicopathological features. Further large-scale studies are necessary to confirm our results.
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PURPOSE: To observe the clinical effects of low intensity ultrasound in extraction of totally impacted third molars. METHODS: 40 patients with totally impacted third molars on both sides of the mandible verified by X-ray were selected. After extraction of the teeth, the socket on one side was treated with low intensity ultrasound while the other side underwent no treatment. Statistical analysis was performed with SPSS 10.0 on all patients in form of pain, swelling, dry socket and bone healing. RESULTS: In the experimental group, 4 patients complained of severe pain while 16 patients in the control group (P < 0.05). Moderate or severe swelling were not uncommon in both experimental and control groups (P > 0.05); No patients suffered from dry socket in the experimental group and 4 patients suffered from dry socket in the control group (P < 0.05); There were 35 patients with complete bone healing in the experimental group while 21 patients with complete bone healing in the control group (P < 0.01). CONCLUSIONS: The use of low intensity ultrasound in extraction of totally impacted mandibular third molars reduced the severity of post-operative pain and the incidence dry socket, and it also stimulated bone healing, but it showed no effect on relieving post-operative swelling.