RESUMO
Miller Fisher syndrome is characterized by ataxia, ophthalmoplegia, and reduced or absent tendon reflexes. Generally, it is considered an acute postinfectious paralytic illness caused by a wide variety of infections including Campylobacter jejuni. The authors report the case of a 10-year-old girl with Miller Fisher syndrome who had a previous infection of Escherichia coli. If confirmed by other reports, this report could disclose a new association of Miller Fisher syndrome with E coli infection.
Assuntos
Infecções por Escherichia coli/complicações , Síndrome de Miller Fisher/etiologia , Criança , Feminino , HumanosRESUMO
To evaluate the predictive factors of response to anticonvulsant therapy in children with complex partial epilepsy, we studied prospectively 74 children and adolescents suffering from this type of epilepsy. All children were prospectively followed for at least 2 years after the beginning of anticonvulsant therapy. At the end of follow-up, the children were subdivided into two groups according to the frequency of seizures: group A, children who were seizure free in the last year, and group B, children with at least six seizures in the previous year. Children with a poor response to anticonvulsant therapy had a more frequent personal history of neonatal seizures, an interval of less than 6 months between the first and the second seizures, and persistent abnormal electroencephalograms than the seizure-free patients and were often treated with polytherapy.
Assuntos
Anticonvulsivantes/uso terapêutico , Epilepsia Parcial Complexa/tratamento farmacológico , Epilepsia Parcial Complexa/fisiopatologia , Idade de Início , Carbamazepina/uso terapêutico , Criança , Quimioterapia Combinada , Eletroencefalografia , Feminino , Seguimentos , Humanos , Lamotrigina , Masculino , Fenobarbital/uso terapêutico , Valor Preditivo dos Testes , Estudos Prospectivos , Recidiva , Fatores de Risco , Resultado do Tratamento , Triazinas/uso terapêutico , Ácido Valproico/uso terapêuticoRESUMO
To understand the evolution of photosensitivity and to evaluate if its disappearance is related to the response to anticonvulsant therapy, we performed a long-term study of 42 patients (17 males, 25 females; age at onset 6 years 9 months, SD 5 years 2 months, range 5 years to 12 years 1 month) who had electroencephalography (EEG) evidence of photosensitive epilepsy. Of the patients, 36 were treated with valproate (VPA) monotherapy and four received VPA in combination with other antiepileptic drugs (AEDs), which were carbamazepine and lamotrigine. Two patients were given no drugs, but treated with stimuli avoidance. All patients were investigated with EEG by using intermittent photic stimulation. The photoparoxysmal response indicated the presence of photosensitivity. At the end of follow-up, the photoparoxysmal response had disappeared in 25 patients. Thirty-three patients became seizure-free. Our study confirms that photosensitive epilepsy has a good prognosis for seizure control that is independent of the persistence or disappearance of photosensitivity.
Assuntos
Anticonvulsivantes/uso terapêutico , Epilepsia Reflexa/complicações , Epilepsia Reflexa/tratamento farmacológico , Transtornos de Fotossensibilidade/complicações , Transtornos de Fotossensibilidade/tratamento farmacológico , Ácido Valproico/uso terapêutico , Adolescente , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Quimioterapia Combinada , Eletroencefalografia/métodos , Feminino , Seguimentos , Humanos , Inteligência/fisiologia , Masculino , Estimulação Luminosa , Estudos Prospectivos , Resultado do Tratamento , Escalas de Wechsler/estatística & dados numéricosRESUMO
Atypical features of rolandic epilepsy are not uncommon, although the long-term prognosis of this condition is not known. Eighty-five children (50 male and 35 female) attending the Department of Pediatrics of the University of Chieti, the Department of Pediatrics of Brindisi Hospital, and the Department of Neurology of San Valentino Hospital were selected for the study; these patients were subdivided into two groups according to their clinical presentation. Group A consisted of children who suffered from typical rolandic epilepsy and Group B consisted of children with atypical features of rolandic epilepsy. All patients of both groups were re-evaluated after at least 8 years from the first evaluation, and the frequency of seizures and the response to treatment were similar in the two groups of children. In spite of this fact, in patients who suffered from atypical rolandic epilepsy, we found a significantly higher percentage of learning and behavioral disabilities than in children affected by the classical form of rolandic epilepsy (45.5% vs 7.8%; P < 0.0001). In conclusion, atypical rolandic epilepsy seems to be associated with a high percentage of learning and behavioral disorders.