RESUMO
Gd-DTPA-enhanced MR images of experimental bacterial meningitis were obtained after Staphylococcus aureus was inoculated directly into the cisterna magna of four dogs. Each animal was studied with both unenhanced and enhanced MR and CT with Gd-DTPA and meglumine iothalamate, respectively. The enhancement patterns resulting from these techniques were compared and images were correlated with histopathology. All animals demonstrated abnormal leptomeningeal enhancement on MR with Gd-DTPA, but only one of four dogs exhibited abnormal contrast enhancement on CT. In these animals Gd-DTPA-enhanced MR also identified complications of meningitis, such as ventriculitis and cerebritis, more effectively than CT did. Unenhanced MR was not helpful in identifying meningitis. Histologic evaluation demonstrated that the abnormal areas of contrast enhancement on MR and CT correlated with inflammatory cell infiltration. However, some regions of mild leptomeningitis, ependymitis, and cerebritis identified histologically did not demonstrate abnormal enhancement. Since the animal model used was clinically and pathologically similar to human meningitis, we propose that Gd-DTPA-enhanced MR will subsequently be found more effective than unenhanced MR and IV contrast-enhanced CT for demonstrating meningitis and its complications in humans.
Assuntos
Meios de Contraste , Imageamento por Ressonância Magnética , Meningite/diagnóstico , Compostos Organometálicos , Ácido Pentético , Infecções Estafilocócicas/diagnóstico , Tomografia Computadorizada por Raios X , Animais , Cães , Estudos de Avaliação como Assunto , Gadolínio DTPA , Meningite/diagnóstico por imagem , Infecções Estafilocócicas/diagnóstico por imagemRESUMO
Tiazofurin is an experimental chemotherapeutic agent currently undergoing clinical evaluation. We report our results with magnetic resonance (MR) in demonstrating reversible cerebral abnormalities concurrent with the use of this drug. The abnormalities on MR were correlated with findings on CT as well as with cerebral angiography. The utility of MR in the evaluation of patients receiving this new agent is illustrated.
Assuntos
Antineoplásicos/efeitos adversos , Encefalopatias/induzido quimicamente , Encefalopatias/diagnóstico , Imageamento por Ressonância Magnética , Ribavirina/efeitos adversos , Ribonucleosídeos/efeitos adversos , Feminino , Humanos , Pessoa de Meia-Idade , Ribavirina/análogos & derivadosAssuntos
Astrocitoma/patologia , Aqueduto do Mesencéfalo/patologia , Neoplasias do Ventrículo Cerebral/patologia , Embolia e Trombose Intracraniana/patologia , Imageamento por Ressonância Magnética/métodos , Esclerose Tuberosa/patologia , Adulto , Derivações do Líquido Cefalorraquidiano , Diagnóstico Diferencial , Humanos , Hidrocefalia/patologia , Masculino , Complicações Pós-Operatórias/patologiaRESUMO
Central pontine myelinolysis is a demyelinating disorder with characteristic magnetic resonance features. Findings on T1-weighted scans include a symmetric region of low signal involving the basilar pons with sparing of the descending corticospinal tracts as well as the peripheral pontine tissues. The T2-weighted images show an area of high signal corresponding to the abnormal region identified on T1-weighted scans. Associated extrapontine demyelinating lesions are also demonstrated.