MyoFold: Joint myocardial tissue composition and wall motion quantification via a highly folded sequence.

PURPOSE: This study aims to develop and evaluate a novel cardiovascular MR sequence, MyoFold, designed for the simultaneous quantifications of myocardial tissue composition and wall motion. METHODS: MyoFold is designed as a 2D single breathing-holding sequence, integrating joint T1/T2 mapping and cine imaging. The sequence uses a 2-fold accelerated balanced SSFP (bSSFP) for data readout and incorporates electrocardiogram synchronization to align with the cardiac cycle. MyoFold initially acquires six single-shot inversion-recovery images, completed during the diastole of six successive heartbeats. T2 preparation (T2-prep) is applied to introduce T2 weightings for the last three images. Subsequently, over the following six heartbeats, segmented bSSFP is performed for the movie of the entire cardiac cycle, synchronized with an electrocardiogram. A neural network trained using numerical simulations of MyoFold is used for T1 and T2 calculations. MyoFold was validated through phantom and in vivo experiments, with comparisons made against MOLLI, SASHA, T2-prep bSSFP, and the conventional cine. RESULTS: In phantom studies, MyoFold exhibited a 10% overestimation in T1 measurements, whereas T2 measurements demonstrated high accuracy. In vivo experiments revealed that MyoFold T1 had comparable accuracy to SASHA and precision similar to MOLLI. MyoFold demonstrated good agreement with T2-prep bSSFP in myocardial T2 measurements. No significant differences were observed in the quantification of left-ventricle wall thickness and function between MyoFold and the conventional cine. CONCLUSION: MyoFold presents as a rapid, simple, and multitasking approach for quantitative cardiovascular MR examinations, offering simultaneous assessment of tissue composition and wall motion. The sequence's multitasking capabilities make it a promising tool for comprehensive cardiac evaluations in clinical settings.

Simultaneous detection of eight phenols in food contact materials after electrochemical assistance solid-phase microextraction based on amino functionalized carbon nanotube/polypyrrole composite.

An electrochemical assistance solid-phase microextraction (EA-SPME) was developed based on amino functionalized multi-walled carbon nanotube/polypyrrole (MWCNTs-NH2/PPy) composite coating. It was applied for the extraction of eight phenols in food contact material, including 2-chlorophenol, o-cresol, m-cresol, 2,4-dichlorophenol, 4-tert-butylphenol, 4-chlorophenol, 4-tertoctylphenol and alpha-naphthol. MWCNTs-NH2/PPy coating was characterized by scanning electron microscopy, transmission electron microscope, X-ray energy spectrometer, X-ray diffraction, Fourier transform infrared and thermogravimetric analysis. The adsorption mechanism of phenols on the composite coatings was investigated. The coating modified steel-wire as an extraction fiber has good electroconductibility, reproducibility and long service life. A determination method for the eight phenols was established by EA-SPME coupled with gas chromatography-flame ionization detection. Under the optimal experimental conditions (extraction temperature: 40 °C; extraction time: 30 min; stirring rate: 600 rpm; NaCl concentration: 0.15 g mL-1; desorption temperature: 250 °C and desorption time: 4 min), the detection linear range was 0.005-50 µg L-1 (R2>0.99), and the detection limit was 0.001-0.1 µg L-1 (S/N = 3). For the quintuple analysis of 50 µg L-1 phenols, the single fiber RSDs were 2.2-12.4%, and the fiber-to-fiber RSDs were 1.9-10.5%. The method was used to detect the migration quantity of the eight phenols from five canned packaging materials, which showed satisfactory recovery 87.3-118.9%.