The role of mean platelet volume in nonalcoholic fatty liver disease without cardiovascular comorbidities, obesity and diabetes mellitus.

BACKGROUND: While the relation of mean platelet volume (MPV) with inflammatory diseases is obvious, its role in nonalcoholic fatty liver disease (NAFLD) without cardiovascular comorbidities, obesity and diabetes mellitus is not clear. METHODS: A total of 249 patients (nonobese, nondiabetic and not having cardiac diseases) who underwent an abdominal ultrasonography assessment were enrolled. They were divided according to the absence (group 1) or presence (group 2) of hepatic steatosis. The patients with steatosis were further divided according to the severity of steatosis as group 2a (grade 1), 2b (grade 2) and 2c (grade 3). The demographic and laboratory features were compared between groups. RESULTS: Hepatic steatosis was absent in 120 patients and detected in 129 patients (grade 1, 2, 3 hepatic steatosis in 75, 49 and 5 patients, respectively). BMI, aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and serum AST, ALT, triglyceride levels were significantly higher in group 2 than in group 1 (P < 0.001, P < 0.001, P < 0.001, P = 0.005, P < 0.001, respectively). BMI, serum AST and triglyceride levels were significant factors for NAFLD (P < 0.001, P = 0.018, P = 0.001). MPV was neither different between groups (P > 0.05) nor a predictor factor for NAFLD (P > 0.05). CONCLUSION: MPV is a useless parameter to detect NAFLD without cardiovascular comorbidities, obesity and diabetes mellitus.

Acute renal failure associated with diphosphonic acid (HEDP): a case report.

UNLABELLED: A 26-year-old man with no significant past medical history presented to emergency department 1 hr after ingesting approximately 200 ml of HEDP 2010 organophosphoric acid corrosion inhibitor. He had normal vital signs, physical examination and biochemical parameters. After 24 hr, he developed nausea with a decreased urine output. While his blood urea nitrogen, creatinine and uric acid levels increased to 36 mg/dl, 3.87 mg/dl, and 8.4 mg/dl, respectively; his serum calcium and phosphorus levels decreased to 7.4 mg/dl and 1.4 mg/dl, respectively. He had proteinuria, glucosuria, leukocyturia and high phosphorus excretion in the urine. On ultrasonographic examination, the kidneys were slightly enlarged and edematous. On the third day of hospitalization, creatinine level increased to 8.81 mg/dl and metabolic acidosis developed. He underwent to hemodialysis therapy and renal functions improved uneventfully. CONCLUSION: This case represents an example of acute renal failure developed and recovering uneventfully after unintentionally ingestion of a bisphosphonate used in industry.