Design and synthesis of novel ß-carboline-bisindole hybrids as potential anticancer agents.

We are reporting a short and convenient pathway for the synthesis of novel ß-carboline-bisindole hybrid compounds from relatively cheap and commercially available chemicals such as tryptamine, dialdehydes and indoles. These newly designed compounds can also be prepared in high yields with the tolerance of many functional groups under mild conditions. Notably, these ß-carboline-bisindole hybrid compounds exhibited some promising applications as anticancer agents against the three common cancer cell lines MCF-7 (breast cancer), SK-LU-1 (lung cancer), and HepG2 (liver cancer). The two best compounds 5b and 5g inhibited the aforementioned cell lines with the same range of the reference Ellipticine at less than 2 µM. A molecular docking study to gain more information about the interactions between the synthesized molecules and the kinase domain of the EGFR was performed. Therefore, this finding can have significant impacts on the development of future research in medicinal chemistry and drug discovery.

Exploring economic and environmental efficiency in renewable energy utilization: a case study in the Organization for Economic Cooperation and Development countries.

The share of renewable energy has grown significantly in global energy supply, yet the evaluation of renewable energy utilization has remained limited. Hence, this research explored economic and environmental efficiency in renewable energy utilization in 20 OECD (The Organization for Economic Cooperation and Development) countries from 2015 to 2020. The study approached the data envelopment analysis-slack-based measure (DEA-SBM) to evaluate economic efficiency, and the DEA undesirable output to measure environmental efficiency. Four inputs as labor force, gross capital formation, total renewable energy capacity, and share of renewable energy were compared to two desirable outputs as the gross domestic product (GDP), and total energy production in the economic efficiency model. In the environmental efficiency model, the same inputs were evaluated with GDP as the desirable output and CO2 emissions as the undesirable output. The DEA-SBM revealed that Australia, Belgium, Norway, the UK, and the USA were efficient in economic evaluation, whereas DEA undesirable output indicated that Belgium, France, Sweden, the UK, and the USA were efficient in environmental evaluation. The governments are suggested to adjust the resources management since the number of efficient units decreased in the economic assessment while fluctuating in the environmental assessment.

Offshore wind power station (OWPS) site selection using a two-stage MCDM-based spherical fuzzy set approach.

In response to challenges from the COVID-19 pandemic and climate change to achieve the goal of ensuring sustainable economic growth, offshore wind power development not only provides a clean and sustainable source of energy but also provides opportunities for economic growth and job creation. Offshore wind energy projects have been promptly suggested in Vietnam due to policy advancement, with the country's excellent wind resources. The success of an offshore wind energy project is decided mainly by choosing the best location for offshore wind power station (OWPS) construction, which is a complex multicriteria decision-making (MCDM) problem with the coexistence of conflicting factors. There is a problem with incomplete decision information use and information loss during the decision-making process, and it is easy to overlook the interaction difficulty in a fuzzy environment. To address the complex nature of the prioritization problem posed, this study proposes a hybrid MCDM framework combining the spherical fuzzy analytical hierarchy process (SF-AHP) and weighted aggregated sum product assessment (WASPAS). SF-AHP is used in the first stage to determine the significance levels of OWPS evaluation criteria. WASPAS is then utilized to rank locations of OWPS. A comprehensive set of evaluation criteria developed based on the concept of sustainable development has been recognized by reviewing the literature review and interviewing experts to practice the two-stage MCDM model. A real case study for Vietnam is conducted to test the effectiveness of the proposed method. The best location schemes have been determined by using the decision framework. The results of the sensitivity analysis and a comparison analysis demonstrate that the decision framework is practical and robust. The proposed methodology can be used to attain a decision-making process at the regional level for offshore wind farm planning and coastal development, and the study results encourage the establishment of renewable energy development policies.

Facile synthesis of 4- and 7-azaindoles from the corresponding imines by palladium-catalyzed cascade C-C and C-N coupling.

The cyclization of 2,3-dihalopyridines with readily available imines provides a convenient and regioselective approach to 4- and 7-azaindoles. The regioselectivity can be controlled by the choice of the halogen atoms at the pyridine ring (chlorine versus bromine).