[The effect of microwave resonance therapy on the clinical and metabolic indices of diabetic patients]. / Vliianie mikrovolnovoi rezonansnoi terapii na nekotorye klinicheskie i metabolicheskie pokazateli u bol'nykh sakharnym diabetom.

It has been established during studies carried out in 195 diabetes mellitus patients that the action of microwave resonance therapy on the points used in traditional acupuncture accelerates carbohydrate metabolism compensation, improves peripheral circulation. The beneficial effect of microwave resonance therapy on the clinical and metabolic characteristics in diabetes mellitus patients is likely to be determined by the lowering of the content of certain contrainsular hormones (cortisol, adrenaline) and by the improvement of the parameters of the T-cell immunity system.

[Effect of the transplantation of cultured pancreatic islet cell on the status of diabetic microangiopathy]. / Vliianie transplantatsii kul'tury ostrovkovykh kletok podzheludochnoi zhelezy na sostoianie diabeticheskikh mikroangiopatii.

Investigation of the effect of allo- and xenotransplantation of pancreatic tissue cultures on the hemodynamic indices of 85 patients with diabetes mellitus using ophthalmoscopy, biomicroophthalmoscopy, integral rheography, capillaroscopy and clinical biochemical tests at varying time (from 3 mos to 4 yrs.) showed a gradual improvement of the ophthalmological picture of the fundus of the eye in 58 patients (86%) during the first 9 mos with further stabilization of a process. Lower limb improvement was noted in 18% of the patients, stabilization of a process--in 74%. The improvement of the renal clinico-biochemical indices was noted in 47-67%. Contraindications for beta = culture transplantation were diabetic glomerulosclerosis with stage III chronic renal insufficiency and retinopathy of diabetorenal type.

[Microcirculatory disorder in the bulbar conjunctiva of patients with diabetic retinopathy]. / Narushenie mikrotsirkuliatsii bul'barnoi kon''iunktivy u bol'nykh s diabeticheskimi retinopatiiami.

Biomicroscopy was employed to study the state of microcirculation of the bulbar conjunctiva in 166 patients with diabetes mellitus at different stages of the ophthalmoscopic assessment of the fundus of the eye. Disorder in conjunctival microhemodynamics was found in 89.7% of the patients, in the presence of retinopathy in all the cases and in a normal picture of the fundus of the eye in 69.3%. Qualitative and quantitative changes in microcirculation of the conjunctiva were shown to depend on the stage and form of diabetic retinopathies. Values of changes of the total conjunctival index and its constituents were on an increase with aggravation of a pathological process in the fundus of the eye. Vascular changes prevailed in the diabetic-sclerotic and diabetic-hypertensive forms of retinopathies, intravascular changes and perivascular edema prevailed in the diabetic-renal form.

[Cellular immunity in patients with diabetes mellitus complicated by diabetic retinopathies]. / Sostoianie kletochnogo immuniteta u bol'nykh sakharnym diabetom, oslozhennym diabeticheskimi retinopatiiami.

A total of 200 patients with diabetes mellitus were examined for T and B immunity systems. The T and B lymphocytes were counted, the response of T lymphocytes to PHA and their sensitivity to thymosine and theophylline were determined. The data obtained attest to inhibition of the T immunity system in patients with diabetes mellitus regardless of the ophthalmoscopic appearance of the eye fundus, with this inhibition being most remarkable in subjects without vascular lesions of the retina. Patients with proliferating diabetic retinopathy manifested activation of the B cell component of immunity. Changes in the content and function of T lymphocytes were followed by inhibition of the hormonal activity of the thymus and accumulation in the blood of the theophylline-sensitive T cell population. It is suggested that quantitative and qualitative deficiencies of cellular immunity give rise to the development of immune complex pathology resulting in the formation and progression of diabetic retinopathies.

[Comparative evaluation of the microcirculatory disorders in diabetes mellitus]. / Sravnitel'ania otsenka mikrotsirkuliatornykh narushenii u bol'nykh sakharnym diabetom.

Parallel studies of different microcirculatory channel parts were performed in 700 patients with diabetes mellitus. Clinical manifestations of disturbed microhemodynamics of the eye fundus, conjunctiva, kidneys, lower limbs were investigated by means of bulbar conjunctival biomicroscopy, ophthalmoscopy, fluorescent retinal angiography, nail-bed capillaroscopy and polarography, and radioisotopic renography. Ultrastructure of the leg muscular capillaries was studied by electron microscopy. The injury of the conjunctival vessels was seen in 81.9% of cases, of the eye fundus in 49.7%, of the kidneys in 45.6%, of the lower limbs in 84.3% and of the capillary muscular ultrastructure in 100%. Phasic character of the microcirculatory channel disorders was revealed. The data obtained are indicative of the possibility of early preclinical diagnosis of diabetic microangiopathies, determination of the degree of vascular lesions, whose prophylaxis and treatment should be carried out systematically and purposefully, beginning from the time of their revealing.

[Blood circulation in the conjunctival blood vessels of patients with diabetes mellitus]. / Sostoianie krovoobrashcheniia v sosudakh kon'iunktivy glaza u bol'nykh sakharnym diabetom.

The state of the microciculatory system of the eye cojunctiva was studied in 107 patients suffering from diabetes mellitus and in 30 practically healthy persons. 85% of diabetic patients displayed marked changes in the conjunctival hemodynamics with a deranged tone and structure of microvessels, increase in their permeability and resistance, and also in worstened blood rheological properties. Disturbances of the conjunctival microcirculation observed from the first years of diabetes mellitus onset reached the maximum in the moderately severe form of diabetes over 10 years in duration with intense diabetic microangiopathies. In comparing the results of a study of the conjunctival and retinal vessels, conjunctival microcirculation was found to be disturbed in 68% of patients with the normal ophthalmological picture of the optic fundus and in all patients with diabetic retinopathies. Microphotography of the conjuctival vessels is recommended in patients with diabetes mellitus for early diagnosis of microhemodynamic disturbances.

[State of the microcirculation in the relatives of diabetes mellitus patients]. / Sostoianie mikrotsirkuliatsii u rodstvennikov bol'nykh sakharnym diabetom.

The biomicroscopic study of the conjunctival vessels demonstrated microcirculation disturbances in 43.8% of 105 relatives of diabetic patients, and in 8.5% changes of the optic fundus vessels, irrespective of the glucose tolerance test results. There was a statistically significant difference between the total conjunctival index and its partial values in the relatives of diabetic patients in comparison with the control (healthy) group, and in patients with newly diagnosed diabetes mellitus as compared with the control group and with the group of relatives with a normal glucose tolerance test.

[Certain metabolic and vascular changes in the relatives of patients with diabetes mellitus]. / Nekotorye metabolicheskie i sosudistye izmeneniia u rodstvennikov bol'nykh sakharnym diabetom

On the basis of instrumental and biochemical study of 186 relatives suffering from diabetes mellitus it was revealed that the diabetic type of sugar curve was encountered in 17.2% of cases, doubltful--in 15.6%; at the same time there was revealed an increase in the immunoreactive insulin level both on fasting stomach and after the glucose load, and a distrubance of fat-lipoid metabolism. Functional changes in the vessels of different calibre independent of the GTT character, accompanied by a reduction of vascular permeability and tissue circulation were revealed in some of the persons examined.

[Incidence of diseases of the cardiovascular system in patients with diabetes during various types of therapy]. / Chastota porazhenii serdechno-sosudistoi sistemy u bol'nykh diabetom pri razlichnykh vidakh lecheniia

A study was made of the effect of the character of the sugar-reducing therapy on the incidence and the severity of diabetic angiopathies in 1365 patients treated at the clinics of Kiev and Kharkov Institutes of Endocrinology. The character of the sugar-reducing therapy did not produce any significant effect on the indicence and the severity of the vascular affections in diabetes mellitus on condition of its compensation and with the consideration to the patient's age.