Assuntos
Eritema , Dermatopatias Genéticas , Pessoa de Meia-Idade , Feminino , Humanos , Eritema/diagnóstico , Eritema/etiologia , ExtremidadesAssuntos
Onicomicose , Idoso , Humanos , Estados Unidos , Onicomicose/tratamento farmacológico , Medicare , PrescriçõesRESUMO
Aplasia cutis congenita (ACC) was diagnosed in a newborn with dysmorphic facial features, oligodactyly of the bilateral feet, and hip instability. The neonate's clinical abnormalities in addition to genetic testing confirmed a diagnosis of trichorhinophalangeal syndrome (TRPS) type II. The possibility of concurrent Adams-Oliver syndrome (AOS) is raised.
Assuntos
Displasia Ectodérmica , Síndrome de Langer-Giedion , Deformidades Congênitas dos Membros , Dermatoses do Couro Cabeludo , Displasia Ectodérmica/complicações , Displasia Ectodérmica/diagnóstico , Displasia Ectodérmica/genética , Humanos , Recém-Nascido , Síndrome de Langer-Giedion/complicações , Síndrome de Langer-Giedion/diagnóstico , Síndrome de Langer-Giedion/genética , Deformidades Congênitas dos Membros/diagnóstico , Couro Cabeludo , Dermatoses do Couro Cabeludo/diagnósticoAssuntos
Anticorpos Monoclonais Humanizados/efeitos adversos , Candida glabrata , Candidíase Invasiva/etiologia , Fármacos Dermatológicos/efeitos adversos , Diabetes Mellitus Tipo 2/tratamento farmacológico , Psoríase/tratamento farmacológico , Pielonefrite/etiologia , Sepse/etiologia , Inibidores do Transportador 2 de Sódio-Glicose/efeitos adversos , Compostos Benzidrílicos/efeitos adversos , Candidíase Invasiva/microbiologia , Diabetes Mellitus Tipo 2/complicações , Feminino , Glucosídeos/efeitos adversos , Humanos , Hipoglicemiantes/uso terapêutico , Insulina Detemir/uso terapêutico , Liraglutida/uso terapêutico , Pessoa de Meia-Idade , Psoríase/complicações , Pielonefrite/microbiologia , Recidiva , Sepse/microbiologia , Infecções Urinárias/etiologia , Infecções Urinárias/microbiologiaRESUMO
BACKGROUND: Psoriasis impairs the quality of life of approximately 7.5 million Americans and is associated with serious comorbidities. Because of chronic vascular access and epidermal dysfunction, end-stage renal disease (ESRD) patients with psoriasis may be at greater risk for infection, and psoriasis treatment could affect this risk. METHODS: A retrospective cohort analysis was performed using the United States Renal Data System from 2004-2011 to investigate the association of psoriasis with infections common to ESRD patients, as well as the effect of psoriasis treatment on infection risk as well as mortality. RESULTS: A total of 8,911 psoriasis patients were identified. Psoriasis was associated with a significantly increased risk for all queried infections, especially cellulitis (adjusted relative riskâ¯=â¯1.55), conjunctivitis (1.47), and onychomycosis (1.36). Psoriasis treatment (systemic, local, and light) was associated with a significantly decreased risk of some infections. Psoriasis treatment was also correlated with a significantly decreased risk of mortality, with systemic therapies (biologics and other immunosuppressants) showing the greatest reduction (adjusted hazard ratioâ¯=â¯0.55). CONCLUSIONS: These results suggest that psoriasis-ESRD patients may have an increased risk of infection and treatment of psoriasis is associated with a reduced risk of some infections and improved survival.
Assuntos
Falência Renal Crônica/tratamento farmacológico , Falência Renal Crônica/mortalidade , Psoríase/tratamento farmacológico , Psoríase/mortalidade , Dermatopatias Infecciosas/tratamento farmacológico , Dermatopatias Infecciosas/mortalidade , Corticosteroides/administração & dosagem , Idoso , Estudos de Coortes , Bases de Dados Factuais/tendências , Fármacos Dermatológicos/administração & dosagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mortalidade/tendências , Estudos RetrospectivosRESUMO
Valsalva maneuvers have the potential to cause dermal capillary rupture manifesting as purpura and petechiae. We present a unique case of Valsalva purpura occurring in a 12-year-old girl after blowing up multiple balloons at a birthday party. Obtaining a detailed history proved essential to the diagnosis and curtailed any unnecessary workup or concern.
RESUMO
BACKGROUND: Dermal filler injection in the vicinity of the terminal facial artery (FA) can lead to vascular compromise with devastating consequences, including tissue necrosis, blindness, and stroke. OBJECTIVE: The purpose of this study was to examine lumen diameter and other anatomical features of the terminal FA relevant to dermal filler injection. MATERIALS AND METHODS: Eighteen embalmed adult cadavers were dissected along the distribution of the terminal FA. Gross and microscopic measurements were taken at predetermined points in its course. RESULTS: Mean lumen diameter was largest at the midpoint between the oral commissure and the lateral supra-alar crease (0.81 ± 0.36 mm; point P1) and smallest at the midpoint between the lateral supra-alar crease and the medial canthus (0.43 ± 0.23 mm; point P3). Mean cutaneous depth was deepest at the lateral supra-alar crease (5.06 ± 1.84 mm; point P2) and most superficial at the midpoint between the lateral supra-alar crease and the medial canthus (3.13 ± 2.07 mm; point P3). CONCLUSION: The large-caliber lumen diameter of the terminal FA creates the potential for intra-arterial injection with commonly used filler needles and blunt-tipped cannulas at all points in its course in the nasolabial fold and midface.
Assuntos
Artérias/anatomia & histologia , Técnicas Cosméticas/efeitos adversos , Preenchedores Dérmicos/efeitos adversos , Lábio/irrigação sanguínea , Sulco Nasogeniano/irrigação sanguínea , Idoso , Idoso de 80 Anos ou mais , Artérias/lesões , Cadáver , Preenchedores Dérmicos/administração & dosagem , Feminino , Humanos , Injeções Subcutâneas/efeitos adversos , Injeções Subcutâneas/métodos , Masculino , Pessoa de Meia-IdadeRESUMO
Spinal muscular atrophy (SMA) type 0 is the most severe phenotype of SMA and is characterized by hypotonia, muscle weakness, and respiratory distress. Cutaneous necrosis, first described in an SMA mouse model, can occur in patients with severe disease; the use of targeted treatment versus supportive measures in the setting of skin necrosis is debated. We present a male infant with SMA type 0 with cutaneous necrosis of proximal and distal limbs who improved with supportive care. The seven previously reported cases of SMA skin necrosis are reviewed.