RESUMO
Introduction: Diagnosing and treating lameness in horses is essential to improving their welfare. In equine orthopedic practice, infrared thermography (IRT) can indirectly detect soreness. Non-steroidal anti-inflammatory drugs can treat painful and inflammatory processes in horses. Using IRT, the efficacy of meloxicam (Maxicam Gel®) was evaluated in pre-treating transient synovitis in horses induced by a middle carpal joint injection of lipopolysaccharides (LPS) from E. coli 055:B5 at a dose of 10 endotoxin units. Methods: In a cross-over design, six healthy horses were randomly assigned to receive either 0.6 mg/kg of oral Maxicam Gel® (MAXVO) or a mock administration (control group, C) following a two-week washout period. IRT of the middle carpal joint, visual lameness assessment and joint circumference were recorded over time. Clinical and hematological evaluations were performed. Synovial fluid aspirates were analyzed for total nucleated cell count, total protein, and prostaglandin E2. A mixed effects analysis of variance was performed for repeated measures over time, followed by Tukey's test. A multinomial logistic regression was conducted to determine whether there is a relationship between a thermography temperature change and the lameness score. Results: There were no changes in joint circumference. The MAXVO group showed a lower rectal temperature 4 h after synovitis induction. The C group presented an increase in neutrophils and a decrease in total hemoglobin and hematocrit 8 h after induction. No changes were observed in the synovial fluid between groups. The horses that received meloxicam did not show clinically significant lameness at any time, while the C group showed an increase in lameness 2, 4, and 8 h after synovitis induction. Discussion: IRT indicated that the skin surface temperature of the middle carpal joint was lower in horses who received meloxicam, suggesting a reduction in the inflammatory process induced by LPS. It was observed that the maximum temperature peaks in the dorsopalmar and lateropalmar positions can be utilized to predict the severity of lameness, particularly when the temperature rises above 34°C. Horses pre-treated with meloxicam showed either reduced or no indication of mild to moderate pain and presented a lowehr thermographic temperature, which indicates the effectiveness of Maxicam Gel® as an anti-inflammatory.
RESUMO
Um estudo foi conduzido para avaliar a exigência de lisina digestível e planos nutricionais para frangos de corte machos de alto potencial genético. Quatrocentos e noventa e cinco pintos de um dia, da marca comercial Cobb, com peso médio inicial de 45,6 ± 0,3g foram utilizados, distribuídos em delineamento inteiramente casualizado, com três dietas contendo diferentes níveis de lisina digestível, nove repetições e onze aves por unidade experimental para determinar o melhor nível de lisina para a fase pré-incial (1 a 7 dias de idade) e o melhor plano nutricional para o período total (1 a 21 dias de idade). Os níveis de lisina não influenciaram o consumo de ração das aves. O consumo de lisina digestível aumentou de forma linear com o aumento dos níveis deste aminoácido na ração. O ganho de peso aumentou e a conversão alimentar melhorou de forma quadrática com o aumento dos níveis de lisina digestível. A exigência de lisina digestível de pintos de 1 a 21 dias de idade para melhor ganho de peso e conversão é de 1,30 e 1,29% de lisina digestível, respectivamente, correspondendo aos consumos estimados de 2,68 e 2,64g de lisina digestível. O Plano nutricional PN3 atende as exigências nutricionais de frangos de corte de 1 a 21 dias de idade.
A study was conducted to evaluate the requirement of digestible lysine and nutrition plans for broilers with high genetic potential. Four hundred and ninety five one-day-old Cobb chicks with initial average weight of 45.6g±0.3g were used, allotted in a completely randomized design with three diets containing different levels of lysine, nine replicates, and 11 birds per experimental unit, to determine the best lysine level for the pre-starter phase (1 to 7 days old) and the best nutritional plan for the total period (1 to 21 days of age). Lysine levels did not influence broilers' feed intake. The digestible lysine intake increased linearly with increasing levels of this amino acid in the diet. Weight gain and feed conversion improved quadratically by increasing dietary levels of lysine. Digestible lysine requirement of 1-to-7-day-old male broilers is 1.30 and 1.29% for best weight gain and feed conversion, respectively, corresponding to intakes of 2.68 and 2.64g digestible lysine. The nutritional plan PN3 meets the nutritional needs of male broilers from 1 to 21 days of age.