Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study.

OBJECTIVE: To determine whether early echocardiography screening of low systemic blood flow reduces intraventricular hemorrhage in preterm infants. STUDY DESIGN: Prospective multicenter study in preterm infants below 33 weeks of gestational age at nine neonatal units. Five units performed early echocardiography screening for low systemic blood flow and guided clinical management (exposure group) and 4 units did not (control group). Our main outcome was ≥grade II intraventricular hemorrhage or death within the first 7 days of life. The main analysis used the inverse probability of treatment weighting. RESULTS: Three hundred and thirty-two preterm infants (131 in the exposure group and 201 in the control group) were included. Exposure to early echocardiography screening was associated with a significant reduction in ≥grade II intraventricular hemorrhage or early death [odds ratio 0.285 (95% CI: 0.133-0.611); p = 0.001]. CONCLUSIONS: Early echocardiography screening for low systemic blood flow may reduce the incidence of intraventricular hemorrhage in preterm infants.

Neural correlates of referential/persecutory delusions in schizophrenia: examination using fMRI and a virtual reality underground travel paradigm.

BACKGROUND: The brain functional correlates of delusions have been relatively little studied. However, a virtual reality paradigm simulating travel on the London Underground has been found to evoke referential ideation in both healthy subjects and patients with schizophrenia, making brain activations in response to such experiences potentially identifiable. METHOD: Ninety patients with schizophrenia/schizoaffective disorder and 28 healthy controls underwent functional magnetic resonance imaging while they viewed virtual reality versions of full and empty Barcelona Metro carriages. RESULTS: Compared to the empty condition, viewing the full carriage was associated with activations in the visual cortex, the cuneus and precuneus/posterior cingulate cortex, the inferior parietal cortex, the angular gyrus and parts of the middle and superior temporal cortex including the temporoparietal junction bilaterally. There were no significant differences in activation between groups. Nor were there activations associated with referentiality or presence of delusions generally in the patient group. However, patients with persecutory delusions showed a cluster of reduced activation compared to those without delusions in a region in the right temporal/occipital cortex. CONCLUSIONS: Performance of the metro task is associated with a widespread pattern of activations, which does not distinguish schizophrenic patients and controls, or show an association with referentiality or delusions in general. However, the finding of a cluster of reduced activation close to the right temporoparietal junction in patients with persecutory delusions specifically is of potential interest, as this region is believed to play a role in social cognition.

[Clinical and epidemiologic description of a severe outbreak of Salmonellosis in an urban nursery school]. / Descripción clínica y epidemiológica de un brote grave de salmonelosis en una escuela infantil urbana.

OBJECTIVE: We describe clinically and epidemiologically an outbreak of gastrointestinal infection by Salmonella enterica ser. (serotype) Enteritidis in an urban infant school, which led to high morbidity and significant social alarm. The immediate communication, as well as the adequate study of the outbreak, in both aspects, allowed identifying the pathogen and establishing control measures in a reasonable period of time. Controversial aspects such as the indication of antibiotherapy or the moment of closing the center are discussed. METHODS: We retrospectively collected clinical, analytical and epidemiological information and we reviewed the methodology of the outbreak study and its results. RESULTS: A total of 57 children (3-45 months), were affected and had microbiological confirmation. Diarrhea and fever were the main symptoms. 74% went to the hospital and 37% were admitted (mean stay 3.3 days). Factors associated with admission were: dehydration, significant elevation of acute phase reactants and coagulopathy. Twelve patients received parenteral cefotaxime. There were 2 complications: 1 bacteremia and 1 readmission. The initial suspicion of the origin of the outbreak was food, but the analysis of the control samples was negative. Five workers were positive (2 symptomatic). Epidemiologic Surveillance concluded that the probable origin of the outbreak was an asymptomatic carrier and improper diapers handling. The center was closed for 8 days. Cleaning and disinfection measures were carried out, as well as instruction on diaper changing, and the carriers were followed. CONCLUSIONS: Clustering in time and space of cases should be reported immediately for early control of the outbreak. Children may present severe forms of Salmonella gastroenteritis.

Evaluation of a nurse-led intervention program in heart failure: A randomized trial.

BACKGROUND AND OBJECTIVE: Several trials have evaluated the effect of disease management programs in heart failure (HF) with diverse results. The aim of this study was to develop a simple nurse-led clinic intervention program for patients with HF and assess whether this intervention positively affects the prognosis of patients, their care costs and perceived quality of life (QoL). METHODS: Between 2011 and 2013, 127 patients with reduced ejection fraction were prospectively randomly allocated (1:2) to standard care or intervention program. Primary composite endpoint was all-cause mortality and hospital readmissions. Secondary endpoints were all-cause mortality, all-cause hospital readmissions, readmissions for HF, time to first readmission and QoL improvements assessed by "Minnesota Living with Heart Failure Questionnaire" (MLHFQ). An intention-to-treat analysis was performed. RESULTS: After a median follow-up of 2-years, no differences were found in the primary composite endpoint. Likewise, there were no differences between groups in the predefined secondary endpoints of mortality and readmissions from any cause. However, in the intervention group, readmissions for HF were significantly reduced (35% vs. 18%; p=0.04) and QoL significantly improved (MLHFQ±SD: 2.29±14 vs. 10.9±14.75; p=0.04). CONCLUSIONS: In patients with HF, the use of a nurse-led intervention program significantly improves perceived QoL and reduce HF hospital readmissions.

[Restless legs syndrome: detection, diagnosis, impact on health and utilization of health care resources]. / El síndrome de piernas inquietas: detección, diagnóstico, consecuencias sobre la salud y utilización de recursos sanitarios.

INTRODUCTION: Despite the high prevalence of Restless Legs Syndrome (RLS) reported, little information is available about this disorder in Spain. The present study was conducted to obtain information on this condition from patients identified by a simple screening questionnaire and subsequent diagnostic confirmation by the Primary Care Practitioner (PCP). MATERIALS AND METHODS: Three-stage, cross-sectional and retrospective (resource utilization), observational study in a sample of adult patients (2,047 subject) attending 10 outpatient Primary Care centers in Madrid, Barcelona and Valencia. A screening questionnaire containing the 4 RLS diagnostic criteria was used. Clinical assessment and RLS diagnosis confirmation was performed using a structured questionnaire. Other variables assessed were quality of life by SF-36 questionnaire scoring; sleep by the MOS sleep scale; symptom severity of RLS symptoms by the IRLS scales; health care resource utilization in the previous 12 months by completion of questionnaire following patient chart review. The diagnosis made by the PCP was confirmed in a small sample of patients by a neurologist expert in Movement Disorders. RESULTS: A total of 19.7% (404 out of 2,047) subjects positively answered the 4 diagnostic questions of the RLS screening questionnaire. Of these, 185 (9.0%) reported moderate to severe symptoms at least twice weekly. The PCP made a diagnosis of RLS in 79 of 154 patients completing the diagnostic interview. Thus, prevalence of RLS estimated in this adult population was 4.6%. The predictive value of the screening RLS questionnaire was 51.3%. Average age of symptom onset was 42 years (range: 20 - over 80 years). RLS symptoms were moderately (50.6%) or extremely (38%) distressing and 73.4% of RLS patients slept poorly at least two nights a week. This diagnosis represents 9.4% of all patients presenting to PCP and experiencing poor sleep. Mean score in the IRLS scale (0 - 40) was 19.4. Average score of SF-36 questionnaire (0-100) was 54.6, lower than the Spanish general reference population (61.4). About one third of the RLS patients had seen a physician because of RLS symptoms. However, a diagnosis was made in only 48% of these and only 5% the diagnosis was RLS. CONCLUSIONS: The DECODE RLS - Spain study shows that many patients with classical RLS symptoms frequently see their PCP without being adequately diagnosed and treated. Screening tools such as that used in this study may contribute to the detection of these patients.

[Why do our patients go to hospital emergency departments?]. / Por qué acuden nuestros pacientes a urgencias del hospital?

OBJECTIVE: To analyse the causes of overuse of hospital emergency services (HES). DESIGN: Cross sectional, descriptive study. SETTING: Emergency service at a general hospital. PATIENTS: Patients who attended the HES on their own initiative. MEASUREMENTS AND MAIN RESULTS: Telephone poll to a representative sample of patients attending on their own initiative the emergency department of the 12 de Octubre Hospital in Madrid between October 5th and 12th. Average age: 46.95 (SD, 20.81); 52.2% women and 47.8% men, 50% were ignorant of the existence of primary care emergencies. 77% were ignorant of the existence of ongoing care points. Main motives for attendance at HES were: ignorance of non-hospital emergency services (32%), better technical means (25.6%), quicker care (21%), sensation of vital urgency (11.4%), poor quality of care in PC (8%). The care received at HES was evaluated as positive in 90% of cases, though 33% thought the information provided insufficient, and 34% the waiting-time excessive. Although 40% believed afterwards that their problem could have been resolved in PC, as many as 75% would return to the hospital. CONCLUSIONS: Widespread ignorance of the existence of non-hospital emergency services affects the over-use of HES. Most users use the HES as a service of immediate PC, a rapid way of obtaining health care. Users have a very favourable opinion of HES care, which is not stated in the case of non-hospital emergency services. In order to improve use of the HES, the population needs to receive better health education.

[The prevalence of urinary incontinence in a population over 60 treated in primary care]. / Prevalencia de incontinencia urinaria en la población mayor de 60 años atendida en atención primaria.

OBJECTIVES: To determine the prevalence of urine incontinence (UI) among the over-60 population treated in primary care, identifying the types and associated epidemiological factors. DESIGN: Descriptive and crossover. SETTING: Primary care. PATIENTS: Sample of 400 people aged 60 or over, stratified by sex and chosen from those who attended their health centre spontaneously for a consultation. MEASUREMENTS AND RESULTS: Age, sex, chronic illnesses, treatments, previous childbirths, grade of immobility and presence or absence of involuntary discharge of urine. If the reply was positive: frequency, characteristics and evolution of UI, and prior consultations on the problem were also measured. 400 people (254 women and 146 men). Mean age: 71 (SD = 7.3 years). 145 people (36.2%) recognised they had UI. 43.3% of women and 23.9% of men (p < 0.001) were incontinent. UI prevalence increased with age: 31.7% among the 60-69 year old group; 35% among the 70-79 group; and 53.3% in those over 80. Among women the most common types are stress and urge incontinence, whereas among men the most common are urge and overflow UI. UI prevalence is greater among women with previous childbirths and among immobile patients. Of the 145 people who recognised their UI, only 31 (21.3%) had previously consulted the doctor on this problem, although men had consulted significantly more than women (40% vs. 15.4%; p < 0.01). CONCLUSIONS: Over a third of the people over 60 in our clinics suffer from UI. Prevalence increases with age and is greater among women, especially if there is a history of childbirth. Urge UI predominates among men and stress UI among women. Most people with UI do not consult concerning their problem, for which reason, so as to identify it and adopt corrective measures, women especially must be systematically asked about the symptom.

[The consumption of psychoactive drugs in primary care]. / Consumo de psicofármacos en atención primaria.

OBJECTIVES: To determine the prevalence of the consumption of psychiatric drugs (PD) among people attending the clinic and to relate that consumption to their sociodemographic characteristics and the presence of psychiatric symptoms. DESIGN: Crossover descriptive study. SETTING: Primary Care. PATIENTS: 350 patients over 14, chosen at random from among those who attended the clinic over an eight-week period. INTERVENTIONS: 1) Questionnaire on sociodemographic data and PD consumption; 2) Self-filling of the GHQ-60 (cut-off point 10/11); and 3) Review of the clinical records to determine the kind of PD, dosage, prescriber, chronic illnesses and the number of consultations over the previous year. RESULTS: 301 (86%) completed the study, 21% consumed PDs. 82% were women. The most consumed PDs were: benzodiazepine (74%) and anti-depressives (34%). CONCLUSIONS: There is a high percentage of PD consumers among people who attend the clinic, especially among women, elderly people, the chronically ill, people living alone and those inactive outside the home. The most commonly used pharmacological group was the benzodiazepines. Almost half the patients had psychiatric symptoms, especially those who lived alone and had no activity outside the home.

[Clinical-epidemiological analysis of 159 children with cryptorchidism]. / Análisis clinicoepidemiológico de 159 niños con criptorquidia.

OBJECTIVE: To determine the epidemiological and clinical characteristics of children with Cryptorchidism in our milieu. DESIGN: Crossover study. SETTING: Specialist care. PATIENTS: 159 children referred from Primary Care for a Cryptorchidism study. MEASUREMENTS AND RESULTS: Average age of detection: 1.5-3 years. Laterality: 120 unilateral (73 right and 47 left) and 39 bilateral. Family history of Cryptorchidism in 33 cases (20.7%). 68 children (42.7%) had some anatomical malformation associated with poor testicular descent. This percentage was significantly higher in children with bilateral Cryptorchidism than with unilateral (61.5% vs 36.6%; p < 0.05). Nine children defined with multiple malformation syndromes. Location of the testes after palpation: 29.3% not able to be palpated, 22.7% high inguinal, 23.2% low inguinal, 17.1% sliding, 5% retractile and 2.5% scrotal. All cases showed normal in the hormonal study, except one case of Hypogonadotropic Hypogonadism. CONCLUSIONS: The diagnoses of Cryptorchidism were not early. Family history and associated malformations in the body himself often exist. Hormonal levels are normal. Echography is of little use in locating testes that cannot be palpated.

[Analysis of the use of radiology in primary health care]. / Análisis de la utilización de la radiología en atención primaria.

OBJECTIVE: To analyse the quality of requests in primary care for radiological investigations, by determining both their effectiveness and modifications in the doctors' therapeutic approach and diagnostic opinion caused by the radiological findings. DESIGN: Longitudinal, retrospective study. SETTING: The Embajadores 1 Primary Care team (PCT), Madrid, during 1993. PARTICIPANTS: 203 radiologies on a significant sample of the PCT's catchment population with a clinical history. MEASUREMENTS AND RESULTS: Radiology was requested for 12% of patients seen: males 39.40% and women 60.59%. Average age was 56.64 +/- 1.41. Commonest requests were for: bone (41.87%), thorax (25.12%), abdominal ecography (9.36%) and digestive system (8.37%). Pathology was discovered in 67.98% of cases, with these results considered relevant in 26.60%. The radiological findings caused 18.72% of doctors to change their therapeutic approach or diagnostic opinion. The radiological investigations with most relevant findings were: mammographies (38.46%), barium meals (35.29%) and abdominal ecographies (31.57%). CONCLUSIONS: Bone and thoracic radiologies account for almost 70% of requests. Despite the high percentage of pathological radiographies, only 19% of the x-rays caused any change in the doctor's attitude, which makes us think the correct indication for each case must be analysed.

Hipertensión cava-inferior por empiema tabicado / Inferior vena cava hypertension due to an empyema thoracis

Hemos presentado una rara observación de compresión de la vena cava inferior en sus segmentos inter-hepato-cardíaco y retro-hepático por empiema pleural derecho tabicado; que determinó la existencia de un Sindrome de Budd-Chiari agudo reversible. Los procedimientos de estudio efectuado (Rx de torax, neumoperitoneo y Rx de abdomen, ecografía y T.A.C.) no permitieron establecer el diagnóstico etiológico, sin embargo la T.A.C. mostró la compresión de la vena cava en el sector indicado. Fue la laparotomía exploradora que determinó la existencia de una hepatomegalia de éstasis basculada hacia la izquierda, asi como la existencia de un diafragma convexo. La toracotomía permitió drenar un importante empiema tabicado a presión que ocupaba la mitad inferior de la cavidad pleural. El paciente tuvo buen post operatorio. A propósito del caso presentado y como no se encontraron citas bibliográficas al respecto, se analizaron todos los procesos descriptos que afectan a la vena cava inferior en el sector mencionado