Variations of inorganic ions and dissolved organic matter in different types of peat bogs and its ecological significance.

Peat bogs, which cover only 3% of the global land surface, store about 30% of the global soil carbon (C), and are important carbon pools in terrestrial ecosystems. Dissolved organic matter (DOM) is an important part of carbon cycle in peatland, and also an important participant in biogeo-chemical process of peat. The variation of redox ability of DOM and inorganic ions in surface water, groundwater, and pore water of two sampling peatland (minerotrophic fen, LB; ombrotrophic bog, OS) were analyzed using novel electrochemical method and stable carbon isotope. The results showed that in the LB plot, inorganic elements were rich, and that anaerobic respiration dominated by inorganic electron acceptor was the main process. The redox ability differed across different LB water sources (surface water, groundwater, and pore water), which was mainly affected by the actual redox potentials. Iron and sulfate were generally in reduced state in the profile of pore water. The reaction level and depth of redox active groups of DOM which participated in redox process were influenced by inorganic electron acceptor. In the OS plot, organic matter was extremely rich, and organic electron acceptor contributed significantly in redox process. The redox ability of OS water samples from different sources performed differently, which was also mainly attributed to the actual redox potentials. The redox ability of pore water profile was affected by the chemical composition in peat substance at different depths. Therefore, electron accepting capacities (EAC) and oxidation index (OI) values could be used to identify the redox conditions along the gradient and to indicate the redox state of organic matter in aquatic systems.

Network analysis of microRNAs, genes and their regulation in mantle cell lymphoma.

The pathogenesis of mantle cell lymphoma, a special subtype of lymphoma that is invasive and indolent and has a median survival of 3 to 4 years, is still partially unexplained. Much research about genes and miRNAs has been conducted in recent years, but interactions and regulatory relations of genetic elements which may play a vital role in genesis of MCL have attracted only limited attention. The present study concentrated on regulatory relations about genes and miRNAs contributing to MCL pathogenesis. Numerous experimentally validated raw data were organized into three topology networks, comprising differentially expressed, associated and global examples. Comparison of similarities and dissimilarities of the three regulating networks, paired with the analysis of the interactions between pairs of elements in every network, revealed that the differentially expressed network illuminated the carcinogenicity mechanism of MCL and the related network further described the regulatory relations involved, including prevention, diagnosis, development and therapy. Three kinds of regulatory relations for host genes including miRNAs, miRNAs targeting genes and genes regulating miRNAs were concluded macroscopically. Regulation of the differentially expressed miRNAs was also analyzed, in terms of abnormal gene expression affecting the MCL pathogenesis. Special regulatory relations were uncovered. For example, auto-regulatory loops were found in the three topology networks, key pathways of the nodes being highlighted. The present study focused on a novel point of view revealing important influencing factors for MCL pathogenesis.