Tumor-derived miRNAs as tumor microenvironment regulators for synergistic therapeutic options.

MicroRNAs (miRNAs) are a class of non-coding RNAs that perform post-transcriptional gene regulation. This review focuses on the role of tumor cell-derived miRNAs in the regulation of the tumor microenvironment (TME) via receptor cell recoding, including angiogenesis, expression of immunosuppressive molecules, formation of radiation resistance, and chemoresistance. Furthermore, we discuss the potential of these molecules as adjuvant therapies in combination with chemotherapy, radiotherapy, or immunotherapy, as well as their advantages as efficacy predictors for personalized therapy. MiRNA-based therapeutic agents for tumors are currently in clinical trials, and while challenges remain, additional research on tumor-derived miRNAs is warranted, which may provide significant clinical benefits to cancer patients.

Delayed Phase Transition and Improved Cycling/Thermal Stability by Spinel LiNi0.5Mn1.5O4 Modification for LiCoO2 Cathode at High Voltages.

Increasing the upper cutoff voltage is capable of achieving higher charge capacity, whereas this strategy always causes a dramatic degradation of cycling and thermal stability. In this study, we first report spinel LiNi0.5Mn1.5O4-modified LiCoO2 (LiCoO2@LiNi0.5Mn1.5O4) as an outstanding cathode material. LiCoO2@LiNi0.5Mn1.5O4 retains capacity retention of 81.4% in a full cell between 4.45 and 3.00 V after 400 cycles at 0.5 C and is superior to 55.3% of pure LiCoO2. In situ X-ray diffraction at an upper cutoff voltage of 4.75 V in combination with differential capacity curve reveals that the promoted cycling performance is ascribed to a delay of O3 → H1-3 → O1 phase transitions and a suppression of cobalt dissolution-induced side reactions. Moreover, LiNi0.5Mn1.5O4 modification improves the thermal stability of LiCoO2 by depressing the release of oxygen and the formation of cobalt dendrites.