Site suitability analysis for locating construction and demolition waste transfer station: an Indian case study.

Construction and Demolition Waste Management (CDWM) includes collecting, transporting, processing, and disposing construction and demolition (C&D) waste, where collection and transportation of bulky and voluminous C&D waste contribute significantly to economic and environmental impacts. Transfer station (TS) being a link between various waste management (WM) facilities plays a significant role in collection and transportation of waste. Thus, locating TS at suitable site can help in reducing the overall impacts. Employment of Geographic Information System (GIS) analysis tools in CDWM is a powerful strategy for site suitability study. A case study in Coimbatore, India, is presented in this study using GIS-based multi-criteria analysis for locating C&D waste TS. The criteria for site suitability analysis are chosen based on literature review, regulations, and experts' opinions. Weights of the chosen criteria are estimated using analytic hierarchy process (AHP), and the final suitability map is created by weighted overlay analysis (WOA) in GIS environment. Results provide first-hand information for local decision makers to locate C&D waste transfer station in the chosen study region and report that 12% of the entire area is "highly suitable" for transfer station location.

Antibody responses to collagen peptides and streptococcal collagen-like 1 proteins in acute rheumatic fever patients.

Acute rheumatic fever (ARF) is a serious post-infectious immune sequelae of Group A streptococcus (GAS). Pathogenesis remains poorly understood, including the events associated with collagen autoantibody generation. GAS express streptococcal collagen-like proteins (Scl) that contain a collagenous domain resembling human collagen. Here, the relationship between antibody reactivity to GAS Scl proteins and human collagen in ARF was investigated. Serum IgG specific for a representative Scl protein (Scl1.1) together with collagen-I and collagen-IV mimetic peptides were quantified in ARF patients (n = 36) and healthy matched controls (n = 36). Reactivity to Scl1.1 was significantly elevated in ARF compared to controls (P < 0.0001) and this was mapped to the collagen-like region of the protein, rather than the N-terminal non-collagenous region. Reactivity to collagen-1 and collagen-IV peptides was also significantly elevated in ARF cases (P < 0.001). However, there was no correlation between Scl1.1 and collagen peptide antibody binding, and hierarchical clustering of ARF cases by IgG reactivity showed two distinct clusters, with Scl1.1 antigens in one and collagen peptides in the other, demonstrating that collagen autoantibodies are not immunologically related to those targeting Scl1.1. Thus, anti-collagen antibodies in ARF appear to be generated as part of the autoreactivity process, independent of any mimicry with GAS collagen-like proteins.