Efficacy of Topical Turmeric, Calendula officinalis, and Tulsi (Ayurvedic Gel) in the Management of Erosive Lichen Planus: A Placebo-Controlled Study.

Background: Chronic mucocutaneous symptoms are a hallmark of lichen planus (LP), an inflammatory disease of the stratified squamous epithelium. The most severe type of mucosal lichen is oral erosive lichen planus (OELP). Materials and Methods: Thirty patients were included in this prospective trial, with fifteen patients each assigned to Group A and Group B. Patients were given a choice between a placebo gel and an ayurvedic gel comprising pure turmeric, Calendula officinalis, and tulsi powder in an oral basis. At each appointment, the patients' reactions to therapy were scored on the Tel Aviv-San Francisco Scale, whereas the degree of the fire was rated using a Visual Analog Scale. Data analysis was carried out using IBM's Statistical Package for the Social Sciences (SPSS) Insights version 21. Results: After receiving ayurvedic gel, patients in Group A reported much less burning than those in Group B (placebo). Group A responded better to therapy overall than Group B. Conclusion: This study's findings support the use of an ayurvedic gel made from pure turmeric, Calendula officinalis, and tulsi powder for the treatment of erosive lichen planus.

A systematic review and meta-analysis on ChatGPT and its utilization in medical and dental research.

Since its release, ChatGPT has taken the world by storm with its utilization in various fields of life. This review's main goal was to offer a thorough and fact-based evaluation of ChatGPT's potential as a tool for medical and dental research, which could direct subsequent research and influence clinical practices. METHODS: Different online databases were scoured for relevant articles that were in accordance with the study objectives. A team of reviewers was assembled to devise a proper methodological framework for inclusion of articles and meta-analysis. RESULTS: 11 descriptive studies were considered for this review that evaluated the accuracy of ChatGPT in answering medical queries related to different domains such as systematic reviews, cancer, liver diseases, diagnostic imaging, education, and COVID-19 vaccination. The studies reported different accuracy ranges, from 18.3 % to 100 %, across various datasets and specialties. The meta-analysis showed an odds ratio (OR) of 2.25 and a relative risk (RR) of 1.47 with a 95 % confidence interval (CI), indicating that the accuracy of ChatGPT in providing correct responses was significantly higher compared to the total responses for queries. However, significant heterogeneity was present among the studies, suggesting considerable variability in the effect sizes across the included studies. CONCLUSION: The observations indicate that ChatGPT has the ability to provide appropriate solutions to questions in the medical and dentistry areas, but researchers and doctors should cautiously assess its responses because they might not always be dependable. Overall, the importance of this study rests in shedding light on ChatGPT's accuracy in the medical and dentistry fields and emphasizing the need for additional investigation to enhance its performance. © 2017 Elsevier Inc. All rights reserved.

Smart Smile: Revolutionizing Dentistry With Artificial Intelligence.

Artificial intelligence (AI) has emerged as a transformative technology in various industries, and its potential in dentistry is gaining significant attention. This abstract explores the future prospects of AI in dentistry, highlighting its potential to revolutionize clinical practice, improve patient outcomes, and enhance the overall efficiency of dental care. The application of AI in dentistry encompasses several key areas, including diagnosis, treatment planning, image analysis, patient management, and personalized care. AI algorithms have shown promising results in the automated detection and diagnosis of dental conditions, such as caries, periodontal diseases, and oral cancers, aiding clinicians in early intervention and improving treatment outcomes. Furthermore, AI-powered treatment planning systems leverage machine learning techniques to analyze vast amounts of patient data, considering factors like medical history, anatomical variations, and treatment success rates. These systems provide dentists with valuable insights and support in making evidence-based treatment decisions, ultimately leading to more predictable and tailored treatment approaches. While the potential of AI in dentistry is immense, it is essential to address certain challenges, including data privacy, algorithm bias, and regulatory considerations. Collaborative efforts between dental professionals, AI experts, and policymakers are crucial to developing robust frameworks that ensure the responsible and ethical implementation of AI in dentistry. Moreover, AI-driven robotics has introduced innovative approaches to dental surgery, enabling precise and minimally invasive procedures, and ultimately reducing patient discomfort and recovery time. Virtual reality (VR) and augmented reality (AR) applications further enhance dental education and training, allowing dental professionals to refine their skills in a realistic and immersive environment. AI holds tremendous promise in shaping the future of dentistry. Through its ability to analyze vast amounts of data, provide accurate diagnoses, facilitate treatment planning, improve image analysis, streamline patient management, and enable personalized care, AI has the potential to enhance dental practice and significantly improve patient outcomes. Embracing this technology and its future development will undoubtedly revolutionize the field of dentistry, fostering a more efficient, precise, and patient-centric approach to oral healthcare. Overall, AI represents a powerful tool that has the potential to revolutionize various aspects of society, from improving healthcare outcomes to optimizing business operations. Continued research, development, and responsible implementation of AI technologies will shape our future, unlocking new possibilities and transforming the way we live and work.

Retraction: To Study the Effect of Anterior Palatal Surface Modifications of Complete Denture on Speech Intelligibility Oral Perception and Cortical Brain Function Activity: An In Vivo Study.

[This retracts the article DOI: 10.7759/cureus.33595.].

To Study the Effect of Anterior Palatal Surface Modifications of Complete Denture on Speech Intelligibility Oral Perception and Cortical Brain Function Activity: An In Vivo Study.

BACKGROUND:  The classic maxillary full denture covers the whole palate, preventing the tongue from touching the denture base tissues itself. Thus, it has deleterious effects on cortical brain function and the ability to understand spoken language. AIM:  This study aimed to determine the effect of anterior palatal surface modifications of the complete denture on speech intelligibility oral perception and cortical brain function activity. METHODS AND MATERIALS:  This study compared the speech clarity, oral discernment, and cortical mind capability activity of complete denture wearers in three study groups: a) complete denture wearers with a small opening (SO) in the maxillary front palatal base; b) complete denture patients who wear regular complete denture; c) complete denture patients who did not wear complete denture; and d) complete denture patients who wear a functionally contoured modified palate (FCMP). Patients with no teeth at all underwent four phases of testing to assess their cognitive abilities and speech quality (pitch and volume). In the first phase, partial dentures were used. During phase 2, a conventional full denture was inserted. In the third phase, a palatal base denture was functionally altered. In phase 4, dentures with a little aperture at the front of the palatal base were used.  Results: The values of pitch and intensity of sound in category A with FCMP modification I were 180.76 ± 24.12 and 73.27 ± 9.74, respectively. On the other hand, the values of pitch and intensity of sound in category B with FCMP modification I were 185.41 ± 27.29 and 73.91 ± 8.31, respectively. The values of pitch and intensity of sound in category A with SO modification II were 188.52 ± 21.11 and 76.13 ± 5.21, respectively. On the other hand, the values of pitch and intensity of sound in category B with SO modification II were 194.59 ± 24.02 and 75.21 ± 6.12, respectively. The findings for values of pitch and intensity were statistically significant among the four phases (p < 0.001). The highest speech intelligibility and cortical brain function were observed in phase 4 in both categories A and B, with the highest scores by experts of 3.21 and 3.42, respectively. Conclusion: Based on the findings of this in vivo investigation, it can be concluded that using modified dentures (modification types I and II) following denture installation improves speech intelligibility, oral perception, and cortical brain function activity.

Monkeypox and oral lesions associated with its occurrence: a systematic review and meta-analysis.

Background: A zoonotic, double-stranded DNA virus belonging to the genus Orthopoxvirus, the mpox virus (MPXV) is most common in tropical regions of Central and West Africa. The frequency of monkeypox (mpox) cases, however, has sharply climbed globally since May 2022. Objectives: To establish the threat of mpox in terms of the oral lesions caused in sufferers. Materials and methods: After a thorough study of the literature identified in the PubMed, Web of Science, and Cochrane library databases using the PRISMA framework, 103 papers were found. Using inclusion and exclusion criteria, we chose research that was relevant for our review before shortlisting 14 papers that conformed to the review's guidelines. Results: In the 14 selected studies, it was found that oral lesions were among the first clinical signs of a mpox affliction, with ulcers on the dorsal surface of tongue lips being the most common areas affected. Conclusion: The rarely observed oral lesions of mpox infection may help in the diagnosis and management of this condition. It is critical to keep in mind that recognising and detecting oral lesions in mpox patients opens the door to more research and efficient patient management.

Traumatic Bone Cyst of the Anterior Mandibular Region: A Case Report.

A traumatic bone cyst (TBC) is an unusual non-neoplastic pseudocystic cavity in the bone that is often asymptomatic and slow-growing. It is unexpectedly detected by regular radiography imaging. These lesions are more common in the mandible than they are in the maxilla, and they are often seen in patients older than 40 years of age. A radiolucent unilocular lesion with scalloped margins is the most common radiographic appearance. If the hollow is found to contain blood or straw-colored fluid, surgical exploration is the only way to make a conclusive diagnosis of this uncommon condition. We present a case of an asymptomatic, incidentally diagnosed (on radiograph) traumatic bone cyst in a young patient involving the mandibular anterior region with periapical radiolucency. The case was diagnosed by radiographs and histopathological evaluation.

Evaluation and Comparison of Five-Year Survival of Tooth-Supported Porcelain Fused to Metal and All-Ceramic Multiple Unit Fixed Prostheses: A Systematic Review.

The prosthesis must have good survival despite being functional for at least 5-10 years. This makes sure that the replacement of missing teeth does not become a repeated expense. Of 579 identified articles, 15 met the inclusion criteria for systematic review. Missing teeth replacement materials are divided into two groups: porcelain fused to metal and all ceramics. Data related to survival rates as well as the most common mode of failure is observed from both groups. It was observed that porcelain fused to metal prostheses had an approximately 99.5% survival rate and an approximately 92% survival rate for all-ceramic tooth-supported prostheses after five years of insertion. Porcelain-fused-to-metal (PFM) prostheses had a better survival rate after five years of insertion as compared to all-ceramic prostheses. Porcelain fused to metal should be the treatment of choice for dentists and patients when missing teeth need to be fixed.

Effects of Plant Metabolites on the Growth of COVID-19 (Coronavirus Disease-19) Including Omicron Strain.

According to recent reports out of India, a new strain of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) B1.1.529 Omicron virus has emerged. In comparison to the Wuhan (WHU) strain and the delta variant, this variant showed a far stronger effect on the angiotensin converting enzyme2 (ACE2) receptor. There are several medicinal compounds in plant metabolites, and their diverse chemical structures make them ideal for the treatment of serious illnesses. It's possible that some of these could be useful alternative pharmaceuticals, as well as a starting point for the repurposing of existing medications and new chemical discoveries. SARS-CoV-2 infection triggered a worldwide epidemic of the severe acute respiratory syndrome (SARS). There have been trials for different therapies for SARS-CoV-2 and so also there are recent announcements of extensive research into the development of viable medicines for this global health calamity. After a thorough examination of plant-derived treatments for COVID-19, investigators in the current study decided to focus on plant-derived secondary metabolites (PSMs). According to some researchers, new MDR (Multi-Drug Resistant) antibiotics may one day be developed due to the adaptability of secondary metabolites. Identifying plant metabolites that can treat a wide range of viral infections was one of the study's aims. Many natural medications that could be recommended for the treatment of COVID-19 were discovered as a result of this research, including remedies from plant families, viral candidates that are susceptible, antiviral assays, and mechanisms of therapeutic action. The findings of this study will inspire further research and speed up the development of new antiviral plant-based medications.

Comparative Evaluation of Low-Level Laser Therapy and Topical Triamcinolone Acetonide 0.1% in Recurrent Aphthous Stomatitis Subjects.

Background Recurrent aphthous stomatitis (RAS), sometimes known as canker sores, is an infection of the oral mucous membranes caused by an inflammatory process. Triamcinolone and low-level laser therapy for recurrent aphthous ulcers were studied in this research, which evaluated their clinical efficacy. Methodology Among 60 subjects, 54 subjects fulfilled the inclusion criteria with an age range between 16 and 46 years. Subjects were randomly divided into two groups, the control group who received four times daily topical application of triamcinolone acetonide 0.1% and the test group who underwent a single application of low-level laser therapy on three alternate days. Evaluations were done on day 1, day 3, day 5, and day 10. Data obtained on oral-health-related quality of life (OHR-QoL) using the OHR-QoL questionnaire were used as baseline data. Clinical parameters like pain score were assessed using a visual analog scale, ulcer size using UNC-15 probe, and erythema and healing score were evaluated using erythema and healing scale. Result According to the OHR-QoL data, there was no statistically significant difference in the quality of life of test and control subjects. We found that pain and ulcer size reduced considerably (p=0.007) from the first day to the third day (p=0.000), and then dropped significantly again (p=0.000) on days 3-10 (p=0.000). On days 3 and 5, the test group showed significant reductions in pain and erythema (p=0.13), as well as an improvement in ulcer healing when compared to the control group. On days 3 and 5, the size of the ulcers decreased similarly in the control and test groups. On the 10th day, patients in both groups had less discomfort, erythema, and ulcer size, as well as improved healing of the ulcer. Conclusion Pain and erythema reduction and ulcer healing improvement were significantly higher in subjects in the test group as compared to those in the control group by day 3. The reduction in ulcer size was comparable to the control group on days 3 and 5, while the complete reduction in ulcer size was seen in both groups by day 10.

A Systematic Review and Meta-Analysis of the Effective Contribution of Indian Periodontists to Global Periodontal Research Advancement.

Developed nations put a lot of emphasis on scientific research and produce an enormous volume of avant-garde papers in impactful journals. These publications could serve as the foundation for different policies or other designs. The researchers in this study aimed to use a quantitative bibliometric strategy to analyze the development of Indian periodontists' publishing patterns in the PubMed database up to October 31, 2022. Publications that could be accessed through the PubMed database as of the end of October 2022 were included in the bibliometric study. By using certain search terms on the PubMed search engine, studies were found. Dental, periodontal, gingival, gingivitis, periodontal, periodontitis, and dental implants were among the terms used to find this article. To evaluate articles that are specifically about India, a parallel search was conducted with the following phrases together with "India." Selected parameters were examined in all papers, whether they had or lacked abstracts. Seven studies were selected which were in accordance with the inclusion and exclusion criteria of this study. According to the keyword search, India contributes an average of 5.65% of each keyword category to the PubMed database, since the total number of search results on PubMed for the seven keywords we entered was 1,037,584, and the same keywords when searched by adding the keyword "India" to the keyword generated a total of 58,624. Since the beginning of the last decade, India has recorded tremendous growth in all spheres of scientific literature publication, and the field of periodontics is no exception. Through the PubMed database, Indian periodontists have made a significant contribution to world literature, especially over the past 10 years, with the number of publications increasing nearly exponentially with each passing year.

Analysis of Smile Aesthetic Changes With Fixed Orthodontic Treatment.

INTRODUCTION:  The mouth and teeth are vital in facial aesthetics and the face as a whole is the most critical individual component determining one's physical look. As dentists, we need to be aware that this might significantly alter the care given to a patient since the patient's and the dentist's ideas of beauty may be quite different. This study sought to ascertain how the general public, general dental specialists, and orthodontics all rated the attractiveness of patients who had received orthodontic treatment using a visual scale, as well as how the facial reference could be used to gauge the improvement in smiles. METHODOLOGY:  The attractiveness of 80 continuously treated patients was assessed by comparing their pre- and post-treatment posed grin images. The attractiveness of participants' smiles was evaluated using the Visual Simple Scale, which measures affect, and the Graph of Facial Stylish Reference, which measures objectively. "Making a Jazzy Face Chart" - The analysts were able to fairly evaluate changes in elements such as the symmetry of the smile twist, the position of the gingival peak of the front teeth relative to each other, the height of the incisal edges of the front teeth, the width of the connector band of the front six teeth, and the general tip of the front teeth by referring to photographs taken during treatment. We put the Visual Basic Scale to the test by having five male orthodontists, five male general dental specialists, and five male laypeople rate how much of an improvement they noticed between the before and after photos of a patient's smile. RESULTS:  According to the findings of the first section of the research, orthodontic treatment generally leads to an increase in all indicators. Some instances, however, demonstrated worsening in characteristics such as grin arc consonance, gingival zenith location relative to each other, and incisal edge height. The second half of this research revealed that the opinions of orthodontic specialists, general dentists, and the general public varied with regard to the beauty of a smile. CONCLUSION:  Based on this research, we can say the following: Orthodontic treatment led to improvements in many of the variables that contribute to smile attractiveness, factors include the interproximal width of contact area, the height of the incisal margins of the front teeth, and the location of the gingival zenith in relation to one another, to name a few. The results of this research support the idea that the aesthetics of the smile should be assessed at the last stages of orthodontic treatment when fine adjustments are being made.

Psychometric analysis of stress, anxiety and depression in patients with recurrent aphthous Stomatitis-A cross-sectional survey based study.

BACKGROUND: Recurrent Aphthous Stomatitis is a chronic inflammatory immune mediated condition associated with single or multiple, painful recurring ulcers of the oral mucosa. Psychological stress is a common trigger factor identified for the onset and progression of this condition. The study aimed to evaluate stress, anxiety and depression using the Hospital Anxiety and Depression scale and stress by the General Health Questionnaire in subjects with Recurrent Aphthous Stomatitis (RAS). MATERIAL AND METHODS: The study evaluated subjects with a history of Recurrent Aphthous Stomatitis and compared their psychological stress, anxiety and depression alteration to normal subjects. Seventy-five study subjects were divided into three groups; test group 1 (25 subjects) presenting with RAS, test group 2 (25 subjects) with a history of RAS but without oral ulcers, and 25 normal subjects with no history of RAS formed the control group. Chi square and student t test was used to determine the relationship between psychological variables and recurrent aphthous ulcers. RESULTS: Comparison of stress, Anxiety and Depression between test group 1 and control group, test group 2 and control group was not found to be statistically significant (p< 0.05). Hence, differences were evident when individual questions were analyzed for stress anxiety and depression. Stress and depression were more prevalent in females, students and patients with a history of RAS. CONCLUSIONS: Higher depression and stress levels were evident in subjects with a history of RAS. Psychological stress is a utmost trigger factor for the initiation of recurrent ulcers. Overall, test group patients had a more psychological impact on the quality of life than the control group. Key words:Anxiety, depression, General Health Questionnaire, Hospital Anxiety and Depression scale, Recurrent Aphthous Stomatitis, stress.