How do cognitive behavioral therapy and interpersonal psychotherapy improve youth depression? Applying meta-analytic structural equation modeling to three decades of randomized trials.

Investigating the mechanisms through which psychotherapy brings about desired change can inform efforts to improve therapies. We applied meta-analytic structural equation modeling (MASEM) to assess putative change mechanisms for cognitive behavioral therapy (CBT) as mediators of youth depression treatment outcome. Then, we tested whether candidate mediators (CMs) showed evidence of treatment-specificity to CBT versus interpersonal psychotherapy (IPT). Literature searches identified 34 randomized trials (27 CBT, 6 IPT, 1 CBT/IPT, 3,868 participants, published 1982-2020) that measured seven CMs: negative cognition, social engagement, family functioning, pleasant activity engagement, problem solving, reframing, or avoidance. We assessed mediational pathways and whether posttreatment CMs mediated treatment effects on posttreatment depression symptoms, covarying pretreatment CMs, and symptoms. Treatment type was tested as a moderator of mediational pathways. Results show that negative cognition (24 trials) and pleasant activities (3 trials) mediated depression symptom outcome in CBT. Social engagement and family functioning showed stronger mediation in IPT (5 and 6 trials) than in CBT (14 and 13 trials). We conclude that negative cognition is a robust mediator of CBT but may not be treatment-specific; pleasant activities may also be a mediator of CBT. However, the lack of treatment or mediation effects involving problem solving and reframing contradicts CBT theory. In contrast, social and family mechanisms appear to be IPT-specific mediators. These conclusions are provisional due to small samples examining IPT and several CMs, limitations in CM measurement (i.e., posttreatment retrospective report), and assumptions of MASEM-and will need to be confirmed when more and better evidence accumulates. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Cognition and self-injurious thoughts and behaviors: A systematic review of longitudinal studies.

There is a long tradition in suicide research, accompanied by recent developments in nonsuicidal self-injury (NSSI) research, of examining cognitive processes as potential precursors of risk. But these cognitive processes are often studied separately, and are rarely integrated or directly compared with each other. In an effort to synthesize this literature, this systematic review (n=109 longitudinal studies conducted over the past 10 years) demonstrates how specific cognitive processes predict self-injurious thoughts and behaviors (SITBs), and examines whether intervening on features of cognition may help mitigate SITB risk. Our review reveals that cognitive processes, measured using self-report and behavioral measures, are most often linked to recurrent suicidal ideation. Overall, several patterns emerged. First, SITB-themed cognitions were robust risk factors and proximally associated with SITB outcomes. Second, negatively-valenced cognitive risk factors were the most commonly studied risk factors, relatively robust, and modestly related to SITB outcomes. Third, cognitive deficits (i.e., basic cognitive processes not characterized by thematic content or negative valence) produced mixed findings that suggest a more distal relationship to SITB outcomes. Moreover, our review of treatment articles revealed that while many interventions are informed by the cognitive literature, potential cognitive mechanisms of treatment change are rarely studied. We conclude by outlining key ways that future research can generate more comprehensive cognitive profiles of self-injurious and suicidal individuals.

Introduction: Applying Clinical Psychological Science to Practice.

Mental illness is a prevalent and extraordinarily complex phenomenon. Psychologists have developed distinct approaches toward understanding and treating mental illness, rooted in divergent epistemology. This introduction to the Special Issue on Clinical Psychological Science and Practice provides a brief overview of the scientist-practitioner gap, and explores one step (of many) toward bridging this divide. Seven compelling case illustrations featured in this Special Issue apply empirical findings to case formulation, treatment selection, and assessment across complex and varied clinical presentations. This issue thereby demonstrates the feasibility of integrating research and clinical expertise in mental healthcare.